Protein Alignment PRPS1 and Prps

DIOPT Version :10

• Sequence 1: NP_002755.1
• Gene: PRPS1 / 5631
• HGNCID: 9462
• Length: 318
• Species: Homo sapiens
• Sequence 2: NP_729528.2
• Gene: Prps / 39132
• FlyBaseID: FBgn0036030
• Length: 388
• Species: Drosophila melanogaster
• Alignment Length: 340
• Identity: 280/340 - (82%)
• Similarity: 300/340 - (88%)
• Gaps: 23/340 - (6%)

Human     1 MPNIKIFSGSSHQDLSQKIADRLGLELGKVVTKKFSNQETCVEIGESVRGEDVYIVQSGCGEIND 65
            |||||:|||:||.||:|:|.||||::|||||||||||.|||||||||||||||||||||.|||||
  Fly    48 MPNIKVFSGTSHPDLAQRIVDRLGIDLGKVVTKKFSNLETCVEIGESVRGEDVYIVQSGSGEIND 112

Human    66 NLMELLIMINACKIASASRVTAVIPCFPYARQDKKDK-----------------------SRAPI 107
            |||||||||||||||||||||||||||||||||||||                       |||||
  Fly   113 NLMELLIMINACKIASASRVTAVIPCFPYARQDKKDKLAGSEDNAESKKLAKKNYDWKFRSRAPI 177

Human   108 SAKLVANMLSVAGADHIITMDLHASQIQGFFDIPVDNLYAEPAVLKWIRENISEWRNCTIVSPDA 172
            ||||||||||||||||||||||||||||||||||||||||||||||||:|||.||:|..||||||
  Fly   178 SAKLVANMLSVAGADHIITMDLHASQIQGFFDIPVDNLYAEPAVLKWIKENIPEWKNSIIVSPDA 242

Human   173 GGAKRVTSIADRLNVDFALIHKERKKANEVDRMVLVGDVKDRVAILVDDMADTCGTICHAADKLL 237
            |||||||||||||||:||||||||||||||..|||||||||::||||||||||||||.||||:|:
  Fly   243 GGAKRVTSIADRLNVEFALIHKERKKANEVASMVLVGDVKDKIAILVDDMADTCGTIVHAADRLV 307

Human   238 SAGATRVYAILTHGIFSGPAISRINNACFEAVVVTNTIPQEDKMKHCSKIQVIDISMILAEAIRR 302
            .||||:||||||||||||||||||||||||||||||||||:..|:.|.|||.||:||:.|||:||
  Fly   308 EAGATKVYAILTHGIFSGPAISRINNACFEAVVVTNTIPQDGHMRDCPKIQCIDVSMMFAEAVRR 372

Human   303 THNGESVSYLFSHVP 317
            ||||||||||||:||
  Fly   373 THNGESVSYLFSNVP 387

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PRPS1	NP_002755.1	PrsA	1..314	CDD:440230	276/335 (82%)
		Binding of phosphoribosylpyrophosphate. /evidence=ECO:0000255	212..227		12/14 (86%)
Prps	NP_729528.2	PrsA	48..384	CDD:440230	276/335 (82%)