DRSC/TRiP Functional Genomics Resources

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Protein Alignment TRPV5 and nan

DIOPT Version :10

Sequence 1:NP_062815.3 Gene:TRPV5 / 56302 HGNCID:3145 Length:729 Species:Homo sapiens
Sequence 2:NP_001261833.1 Gene:nan / 39571 FlyBaseID:FBgn0036414 Length:834 Species:Drosophila melanogaster


Alignment Length:719 Identity:201/719 - (27%)
Similarity:333/719 - (46%) Gaps:152/719 - (21%)


- Green bases have known domain annotations that are detailed below.


Human     7 KAEGPGSQLQKLLPSFLVREQDWDQHLDKLHMLQQKRILESPLLRASKENDLSV--------LRQ 63
            |..|....:.||:   |:|.:|    ..:...|.:.|.||:|      ::|.::        ..:
  Fly    66 KGAGRYFPISKLV---LLRNRD----RPRTRQLPEIRALENP------DDDFNIHDYCPEVSEAE 117

Human    64 LLLDCTC------DVRQRGALGETALHIAAL-YDNLEAALV--LMEAAPELVFEPTTCEAFAGQT 119
            .:.:.|.      |:..|||:|||.||:..| ..:|.|.|.  |::..|:|:.:....:.:.|::
  Fly   118 YISNPTAYRFVCWDLNMRGAVGETILHLCLLNASSLHADLAKRLLKFYPKLILDIYMSDEYYGES 182

Human   120 ALHIAVVNQNVNLVRALLTRRASVSARATG-------TAFRH--SPRN-------------LIYF 162
            .||||:||::..:|:.||...|.|..|..|       |.|..  ||.:             .:|:
  Fly   183 VLHIAIVNEDPAMVKYLLDANADVQERCCGAFMSAEDTKFSRTDSPDHEYVALCPMTNYDGYVYW 247

Human   163 GEHPLSFAACVNSEEIVRLLIEHGADIRAQDSLGNTVLHILILQPNKTFACQMYNLLLSYD-GHG 226
            ||:|||||||::.||..||::..|||...||:.||||||:|::...    .:|::  :.|: |..
  Fly   248 GEYPLSFAACLSQEECFRLVLARGADPDFQDTNGNTVLHMLVIYEK----IEMFD--VGYEVGTN 306

Human   227 DHLQPLDLVPNHQGLTPFKLAGVEGNTVMFQHLMQKRRHIQWTYGPLTSILYDLTEIDSWGEEL- 290
            .|::      |.|.|||..||...|...||.|:|...|.|.|..|.:|...|.|..||:..||. 
  Fly   307 IHIK------NIQNLTPLTLAAKLGRVEMFFHVMSIEREIYWQLGSITCAAYPLLMIDTINEETG 365

Human   291 -----SFLELVVSSDKREARQILEQTPVKELVSFKWNKYGRPYFCILAALYLLYMICFTTCCVYR 350
                 |.|..||..||.|..::|:.. |.:|:..||:.:.:..|.....::.||.:......:.|
  Fly   366 NINKDSVLNFVVFGDKLEHLELLDGV-VIDLLKTKWDTFCKSRFYKQFYMFALYFLISLFSFILR 429

Human   351 P---LKFR---GGNRT-----------------HSRDITILQQKL-----LQEAYETRE------ 381
            |   .|..   |.|.|                 ||:..|:..:..     ..|.|:..|      
  Fly   430 PGPDAKDEDEDGANSTTAKSDLYRQNGSDSYHLHSKRATMTTEYKTFWLNFTEYYDPSEVEVLPA 494

Human   382 ---------------DI--IRLVGELVSIVGAVIILLLEIPDIFRVGASRYFGKTILGGPFHVII 429
                           |:  :|::.||::.|||::.||:.:.:...:|. :.|.:.::..|..|:.
  Fly   495 WWESYAQCPLMNLESDLAKLRIMAELLNFVGAILYLLVALREARFLGL-KMFIENLMTAPSRVMF 558

Human   430 ITYASLVLVTMVMR---LTNTNGEVVPMSFALVLGWCSVMYFTRGFQMLGPFTIMIQKMIFGDLM 491
            :...:|::....:|   ||..:..|..:.......:  .::|.|||:.:|||.:||.:|:.|||:
  Fly   559 LFSCALMMTIPWLRVSCLTEIDDHVTVVIMLTTAPY--FLFFCRGFKTVGPFVVMIYRMVMGDLL 621

Human   492 RFCWLMAVVILGFASAFYIIFQTEDPTSLGQFYD-------YPM----ALF----TTF-ELFLTV 540
            ||..:..|.::||:.||||||.|.|..|..:..|       .||    |:|    |.| :.:..:
  Fly   622 RFVSIYLVFVMGFSQAFYIIFLTFDNPSSPEDQDAESNPMPSPMESIVAMFLMSLTNFGDYYGAM 686

Human   541 IDAPANYDVDLPFMFSIVNFAFTIIATLLMLNLFIAMMGDTHWRVAQERDELWRAQVVATTVMLE 605
            :.....|:..:.|      |.|.:|.::|::|:.|||||:|:.::|:.|:| |:.|.....:::|
  Fly   687 VSTQHEYEAKILF------FLFMVIVSVLLVNMLIAMMGNTYQKIAEIRNE-WQRQWARIVLVVE 744

Human   606 RKLP 609
            |.:|
  Fly   745 RSVP 748

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
TRPV5NP_062815.3 TRPV5-6 29..637 CDD:411976 194/697 (28%)
ANK 1. /evidence=ECO:0000255 44..74 6/43 (14%)
ANK repeat 46..76 CDD:293786 5/43 (12%)
ANK 2. /evidence=ECO:0000255 78..107 12/31 (39%)
ANK repeat 79..114 CDD:293786 12/37 (32%)
ANK 3. /evidence=ECO:0000255 116..145 12/28 (43%)
ANK repeat 117..147 CDD:293786 12/29 (41%)
ANK repeat 162..193 CDD:293786 16/30 (53%)
ANK 4. /evidence=ECO:0000255 162..191 16/28 (57%)
ANK 5. /evidence=ECO:0000255 195..228 10/33 (30%)
ANK 6. /evidence=ECO:0000255 239..268 13/28 (46%)
Interaction with S100A10. /evidence=ECO:0000250|UniProtKB:P69744 598..602 0/3 (0%)
CBD_TRPV5_C 649..725 CDD:412091
Involved in Ca(2+)-dependent inactivation. /evidence=ECO:0000250|UniProtKB:Q9XSM3 650..653
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 654..675
Involved in Ca(2+)-dependent inactivation. /evidence=ECO:0000250|UniProtKB:Q9XSM3 700..729
nanNP_001261833.1 TRPV 131..748 CDD:454755 186/639 (29%)
ANK repeat 138..174 CDD:293786 12/35 (34%)
ANK repeat 179..229 CDD:293786 17/49 (35%)
ANK repeat 231..278 CDD:293786 17/46 (37%)
ANK repeat 280..311 CDD:293786 11/42 (26%)
Blue background indicates that the domain is not in the aligned region.

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