Protein Alignment TRPV5 and iav

DIOPT Version :10

• Sequence 1: NP_062815.3
• Gene: TRPV5 / 56302
• HGNCID: 3145
• Length: 729
• Species: Homo sapiens
• Sequence 2: NP_572353.1
• Gene: iav / 31621
• FlyBaseID: FBgn0086693
• Length: 1123
• Species: Drosophila melanogaster
• Alignment Length: 691
• Identity: 165/691 - (23%)
• Similarity: 282/691 - (40%)
• Gaps: 97/691 - (14%)

Human    72 VRQRGALGETALHIAALYD---NLEAALVLMEAAPELVFEPTTCEAFAGQTALHIAVVNQNVNLV 133
            ::.||||||:.||:..:.|   :.:.|.||:...|.|..:....|.:.|.:|||:::...|..||
  Fly   125 MQYRGALGESLLHVLIICDSKVHTKLARVLLRVFPNLALDVMEGEEYLGASALHLSIAYSNNELV 189

Human   134 RALLTRRASVSARATGTAF------RHSP------RNLIYFGEHPLSFAACVNSEEIVRLLIEHG 186
            ..|:...|.:..||.|:.|      |.:|      ..|.|.||:||::|||..:|.:..||::.|
  Fly   190 ADLIEAGADIHQRAIGSFFLPRDQQRANPAKSTDYEGLAYMGEYPLAWAACCANESVYNLLVDCG 254

Human   187 ADIRAQDSLGNTVLHILILQPNKTFACQMYNLLLSYDGHGDHLQPLDLVPNHQGLTPFKLAGVEG 251
            :|..||||.||.:||::::       |...: :..|..........:.:.|..||||..||...|
  Fly   255 SDPDAQDSFGNMILHMVVV-------CDKLD-MFGYALRHPKTPAKNGIVNQTGLTPLTLACKLG 311

Human   252 NTVMFQHLMQKRRHIQWTYGPLTSILYDLTEID--------SWGEELSFLELVVSSDKREARQIL 308
            ...:|:.:::......|.|..:|...|.|..:|        :|.   |.|.::::..|.|...:|
  Fly   312 RAEVFREMLELSAREFWRYSNITCSGYPLNALDTLLPDGRTNWN---SALFIILNGTKPEHLDML 373

Human   309 EQTPVKELVSFKWNKYGRPYFCILAALYLLYMICFTTCCVYRPLKFRGGNRTHSRDITILQQKLL 373
            :...::.|:..||..:.:..|.....:...:::|.:.....||..........|.........||
  Fly   374 DGGIIQRLLEEKWKTFAQNQFLKRLLILSTHLLCLSVSVYLRPAHDGEAEDEDSEGSDASAAALL 438

Human   374 QEAYE---------TREDIIRLVGELVSIVGAVIILLLEIPDIFRVGASRYFGKTILGGPFHVII 429
            ....:         ..:.:.|...|..::||.:..::.:..|..:......|.|.:...|...|.
  Fly   439 DIQSDEGDSGGGDYNAQTVARYCAEFATLVGVLSYVIFQQGDEIKNQGLSAFLKQLSHAPAKAIF 503

Human   430 ITYASLVLVTMVMRLT-NTNGEVVPMSFALVLGWCSVMYFTRGFQMLGPFTIMIQKMIFGDLMRF 493
            :....|:|..:..||. :|:.|...:.||:...|..:|:|....::.|||..||..||.||:..|
  Fly   504 LFSNLLILACIPFRLIGDTDTEEAILIFAVPGSWFLLMFFAGAIRLTGPFVTMIYSMITGDMFTF 568

Human   494 CWLMAVVILGFASAFYIIFQTEDPTSLGQFYDYPMALFTTFELFLTVIDAPANYDVDLPFMFSIV 558
            ..:..:|:.||:.|||.:::.........|..|.......|:..|...:.|.......|.:...|
  Fly   569 GIIYCIVLCGFSQAFYFLYKGHPQVQSTMFNTYTSTWMALFQTTLGDYNYPDLNQTTYPNLSKTV 633

Human   559 NFAFTIIATLLMLNLFIAMMGDTHWRVAQERDELWRAQVVATTVMLERKLPRCLWPRSGICGCEF 623
            ...|.|...:|:||:.|||||:|:..|.::.::.|..|.....|.|||.:|:.  ...|
  Fly   634 FVIFMIFVPILLLNMLIAMMGNTYVTVIEQSEKEWMKQWAKIVVTLERAVPQA--DAKG------ 690

Human   624 GLGDRWFLRVENHNDQNPLRVLRYVEVFKNSDKEDDQEHPSEKQPSGA--ESGTLARASLALPTS 686
                                   |:|.:              ..|.|.  :||...|..:.:.:.
  Fly   691 -----------------------YLEAY--------------SIPLGPSDDSGFEVRGVMVIKSK 718

Human   687 SLSRTASQSSSHRGWEILRQNTLGHL-NLGLNLSEGDGEEV 726
            |.:|...:..:...|:.:.:.||..| ..|:.     |||:
  Fly   719 SKTRAKQRKGAVSNWKRVGRVTLTALKKRGMT-----GEEM 754

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TRPV5	NP_062815.3	TRPV5-6	29..637	CDD:411976	148/597 (25%)
		ANK 1. /evidence=ECO:0000255	44..74		0/1 (0%)
		ANK repeat	46..76	CDD:293786	0/3 (0%)
		ANK 2. /evidence=ECO:0000255	78..107		11/31 (35%)
		ANK repeat	79..114	CDD:293786	10/37 (27%)
		ANK 3. /evidence=ECO:0000255	116..145		9/28 (32%)
		ANK repeat	117..147	CDD:293786	9/29 (31%)
		ANK repeat	162..193	CDD:293786	13/30 (43%)
		ANK 4. /evidence=ECO:0000255	162..191		12/28 (43%)
		ANK 5. /evidence=ECO:0000255	195..228		6/32 (19%)
		ANK 6. /evidence=ECO:0000255	239..268		8/28 (29%)
		Interaction with S100A10. /evidence=ECO:0000250|UniProtKB:P69744	598..602		0/3 (0%)
		CBD_TRPV5_C	649..725	CDD:412091	14/78 (18%)
		Involved in Ca(2+)-dependent inactivation. /evidence=ECO:0000250|UniProtKB:Q9XSM3	650..653		0/2 (0%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	654..675		3/22 (14%)
		Involved in Ca(2+)-dependent inactivation. /evidence=ECO:0000250|UniProtKB:Q9XSM3	700..729		8/28 (29%)
iav	NP_572353.1	TRPV	126..757	CDD:454755	165/690 (24%)
		ANK repeat	132..164	CDD:293786	10/31 (32%)
		ANK repeat	173..203	CDD:293786	9/29 (31%)
		ANK repeat	230..261	CDD:293786	13/30 (43%)
		ANK repeat	299..329	CDD:293786	8/29 (28%)