DRSC/TRiP Functional Genomics Resources

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Protein Alignment cacna1bb and para

DIOPT Version :9

Sequence 1:XP_021324711.1 Gene:cacna1bb / 562796 ZFINID:ZDB-GENE-090514-4 Length:2345 Species:Danio rerio
Sequence 2:NP_001259619.1 Gene:para / 32619 FlyBaseID:FBgn0285944 Length:2145 Species:Drosophila melanogaster


Alignment Length:2064 Identity:502/2064 - (24%)
Similarity:846/2064 - (40%) Gaps:590/2064 - (28%)


- Green bases have known domain annotations that are detailed below.


Zfish    62 FTVNRSLFIFSEDNVIRKYAKRITEWPPFEYLILTTIIANCIVLALEQHLPALDKTPMSERLDDT 126
            |:.::::::....|.||:.|..|...|.|...|:|||:.|||::.:          |.:..::.|
  Fly   127 FSASKAMWMLDPFNPIRRVAIYILVHPLFSLFIITTILVNCILMIM----------PTTPTVEST 181

Zfish   127 EPYFIGIFCFEAGIKIIALGFVFHKDSYLRNGWNIMDFVVVVTGILTTVGSQFDLRTLRAVRVLR 191
            |..|.||:.||:.:|::|.||:....:|||:.||.:||||:....:|......:|..||..||||
  Fly   182 EVIFTGIYTFESAVKVMARGFILCPFTYLRDAWNWLDFVVIALAYVTMGIDLGNLAALRTFRVLR 246

Zfish   192 PLKLVSGIPSLQVVLKSIMKAMVPLLQIGLLLFFAIVMFAIIGVEFYMGKFHFTC---FKVD--- 250
            .||.|:.:|.|:.::.::::::..|..:.:|..|::.:||::|::.|||.....|   |.:|   
  Fly   247 ALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYMGVLTQKCIKKFPLDGSW 311

Zfish   251 -------------------TGEKAVDYP-CGAEPPSRSCPVGTNCTE-YWKGPNFGITNFDNILF 294
                               :.::.:.:| ||....:..|.....|.: :...||:|.|:||:..:
  Fly   312 GNLTDENWDYHNRNSSNWYSEDEGISFPLCGNISGAGQCDDDYVCLQGFGPNPNYGYTSFDSFGW 376

Zfish   295 AILTVFQCITMEGWTDVLYHTNDAAGNTWNWLYFIPLIIIGSFFMLNLVLGVLS---GEFAKERE 356
            |.|:.|:.:|.:.|.| ||.....|...|:.|:||.:|.:|||:::||:|.:::   .|..|:.|
  Fly   377 AFLSAFRLMTQDFWED-LYQLVLRAAGPWHMLFFIVIIFLGSFYLVNLILAIVAMSYDELQKKAE 440

Zfish   357 RVEKRQEFLKLRRQQQIERELTGYLEWICKAEEVLLA-----EEDQNAEEKSPLDGAWYRRKQNN 416
            ..|..:|                  |.|.:|||...|     ||..||:.::..|.|.......:
  Fly   441 EEEAAEE------------------EAIREAEEAAAAKAAKLEERANAQAQAAADAAAAEEAALH 487

Zfish   417 PVLKRTKS------------RKGRND-------LISAEEGDEHFTDI------------------ 444
            |.:.::.:            .||.:|       :.|.|...|..:.|                  
  Fly   488 PEMAKSPTYSCISYELFVGGEKGNDDNNKEKMSIRSVEVESESVSVIQRQPAPTTAHQATKVRKV 552

Zfish   445 --SSVAPPGSPF--ARASLKSSK-----------------------------------NDS---- 466
              :|::.|||||  .|.|..|.|                                   :||    
  Fly   553 STTSLSLPGSPFNIRRGSRSSHKYTIRNGRGRFGIPGSDRKPLVLSTYQDAQQHLPYADDSNAVT 617

Zfish   467 ----------------------SSYFRR-------------------------KEKRIRFFIRRM 484
                                  |||...                         ||.::|   .|.
  Fly   618 PMSEENGAIIVPVYYGNLGSRHSSYTSHQSRISYTSHGDLLGGMAVMGVSTMTKESKLR---NRN 679

Zfish   485 VKAQS------------------------------------------------------------ 489
            .:.||                                                            
  Fly   680 TRNQSVGATNGGTTCLDTNHKLDHRDYEIGLECTDEAGKIKHHDNPFIEPVQTQTVVDMKDVMVL 744

Zfish   490 ---------------------FY------------------------------------------ 491
                                 :|                                          
  Fly   745 NDIIEQAAGRHSRASDRGVSVYYFPTEDDDEDGPTFKDKALEVILKGIDVFCVWDCCWVWLKFQE 809

Zfish   492 W-------------IVLCLVGLNTMCVAIVHYDQPEWLTKALYLAEFVFLGLFLTEMTLKMYGLG 543
            |             |.||:| :|||.:|:.|:|..:.:.:.|....:.|...|..|.|:|:..:.
  Fly   810 WVSLIVFDPFVELFITLCIV-VNTMFMAMDHHDMNKEMERVLKSGNYFFTATFAIEATMKLMAMS 873

Zfish   544 PRNYFHSSFNCFDFGVIVGSIFEVIWAAIQPGASFGISVLRALRLLRIFKVTKYWNSLRNLVVSL 608
            |:.||...:|.|||.::..|:.|:....:|     |:||||:.||||:||:.|.|.:| ||::|:
  Fly   874 PKYYFQEGWNIFDFIIVALSLLELGLEGVQ-----GLSVLRSFRLLRVFKLAKSWPTL-NLLISI 932

Zfish   609 L-NSMKSIISLLFLLFLFIVVFALLGMQLFGGQFN-----FED-ETPTTNFDSFPAAIMTVFQIL 666
            : .:|.::.:|.|:|.:.|.:||::||||||..::     |.| :.|..||..|..:.|.||::|
  Fly   933 MGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNYHDHKDRFPDGDLPRWNFTDFMHSFMIVFRVL 997

Zfish   667 TGEDWNAVMYHGIESQGGVR--GGMFSSVYFIVLTLFGNYTLLNVFLAIAVDNLANA--QELTKD 727
            .|| |       |||.....  |.:....:|:...:.||..:||:|||:.:.|..::  ...|.|
  Fly   998 CGE-W-------IESMWDCMYVGDVSCIPFFLATVVIGNLVVLNLFLALLLSNFGSSSLSAPTAD 1054

Zfish   728 EEQQEEAAKKSLALQKAMEVKEVSPMSAANISIAAFVKQNRDAISRRSSVCSVHSPKEQQRSLQK 792
            .:..:.|.    |..:....|     |....:||...|..|:.::.:.|         .|.|   
  Fly  1055 NDTNKIAE----AFNRIGRFK-----SWVKRNIADCFKLIRNKLTNQIS---------DQPS--- 1098

Zfish   793 LSIWEQRTNQLRRHNLRSSSEALYNELEPEERLRVSSALHLRPDMKTHHDRPLVVEHRDSVDNLR 857
                .:||||:.           :...|.:...|..||.|...:::..||..|.           
  Fly  1099 ----GERTNQIS-----------WIWSEGKGVCRCISAEHGDNELELGHDEILA----------- 1137

Zfish   858 SDKDGDTSEGQPASNHQRKYHKCRGENGDTGEGRLHRHHSQNRENQGG-LERSNSQDGGQRNHHR 921
               ||...:|      .::..:.....||..|..:|.....|:..:.. |..:...|....|.:.
  Fly  1138 ---DGLIKKG------IKEQTQLEVAIGDGMEFTIHGDMKNNKPKKSKYLNNATDDDTASINSYG 1193

Zfish   922 SSGSPEEGIGIEEREHRHHHSRRPREVNGNGNGVIGNGGRGERIRGHREGEGGNGERRRHRPRVK 986
            |                  |..||.:                     .|...|:.|         
  Fly  1194 S------------------HKNRPFK---------------------DESHKGSAE--------- 1210

Zfish   987 AQSTLDGDECRENGGKRRSRPTETDSLTTSPLQSPSEEKPEDKDNLKNSTRVGPSGVNIPVTITA 1051
               |::|:|.|:...:......|.|.      :...||.|                         
  Fly  1211 ---TMEGEEKRDASKEDLGLDEELDE------EGECEEGP------------------------- 1241

Zfish  1052 PPGETTVIPMNNIDGDSLLLNEEKKDLDELNQNAPKHILPYS-------------SMFVFGPTNP 1103
                        :|||.::...::..|||.    |....|.|             |.|..|..| 
  Fly  1242 ------------LDGDIIIHAHDEDILDEY----PADCCPDSYYKKFPILAGDDDSPFWQGWGN- 1289

Zfish  1104 VRRLCHYVVNLRYFEMCILTVITMSSIALAAEDPVQAHAPR----NDVLKYLDYVFTGVFTFEMV 1164
            :|.....::..:|||..::|:|.|||:|||.||   .|.|:    .|:|.|:|.:||.:|..||:
  Fly  1290 LRLKTFQLIENKYFETAVITMILMSSLALALED---VHLPQRPILQDILYYMDRIFTVIFFLEML 1351

Zfish  1165 IKMIDLGLLLHPGSYFRDLWNILDFIVVSGALVAFACSSFMGSQQSVTRGTKGKDINTIKSLRVL 1229
            ||.:.||..:    ||.:.|..|||::|..:|:.|..|..         |..|  |...|::|.|
  Fly  1352 IKWLALGFKV----YFTNAWCWLDFVIVMVSLINFVASLV---------GAGG--IQAFKTMRTL 1401

Zfish  1230 RVLRPLKTIKRLPKLKAVFDCVVNSLKNVLNILIVYILFMFIFAVIAVQLFKGKFFHCTDESKAL 1294
            |.||||:.:.|:..::.|.:.:|.::.::.|:|:|.::|..|||::.||||.||:|.|       
  Fly  1402 RALRPLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKC------- 1459

Zfish  1295 EKDCRGQFLEY---GSDGVAMTQPREWKKYDFHYDNVLWAFLTLFTVSTGEGWPLVLKHSVDATY 1356
             :|..|..|.:   .:.....::...|.....::|:|..|:|.||.|:|.:||..::..::|:..
  Fly  1460 -EDMNGTKLSHEIIPNRNACESENYTWVNSAMNFDHVGNAYLCLFQVATFKGWIQIMNDAIDSRE 1523

Zfish  1357 EDQGPSPGYRMETSIF---YVVYFIVF-PFFFVNIFVALIIITFQEQGDKAMSECSL-----EKN 1412
            .|:.|.    .||:|:   |.|:||:| .||.:|:|:.:||..|.||..||.....:     :|.
  Fly  1524 VDKQPI----RETNIYMYLYFVFFIIFGSFFTLNLFIGVIIDNFNEQKKKAGGSLEMFMTEDQKK 1584

Zfish  1413 ERACIDFAINAKPLTRYMPQDKNSYQYKMWKFVVSTPFEYSILTMIAINTVVLMMKFHGAPKPYE 1477
            ....:....:.||| :.:|:.:...|..:::.|....|:..|:..|.:|...:.:..:.|...|.
  Fly  1585 YYNAMKKMGSKKPL-KAIPRPRWRPQAIVFEIVTDKKFDIIIMLFIGLNMFTMTLDRYDASDTYN 1648

Zfish  1478 DMLKWLNIIFTALFTLECVLKVIAFGPLNYLKEAWNIFDFVTVLGSITDILVTEIKTDKRINLSF 1542
            .:|.:||.||..:|:.||:||:.|. ..:|..|.||:||.|.|:.||..:::::|.....::.:.
  Fly  1649 AVLDYLNAIFVVIFSSECLLKIFAL-RYHYFIEPWNLFDVVVVILSILGLVLSDIIEKYFVSPTL 1712

Zfish  1543 LRLFRAA---RLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVFGNIALNN 1604
            ||:.|.|   |:::|::....||.||:....|..||..:|||:.::.||:||.||..|.::   .
  Fly  1713 LRVVRVAKVGRVLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFFMHV---K 1774

Zfish  1605 EDSAINIHNNFRTFFQALMLLFRSATGEAWHEIMLACLSERYC---DIESGYSGKECGS-DFAYF 1665
            |.|.||...||:||.|:::|||:.:|...|..::.|.::|..|   |.:.||.| .||| .....
  Fly  1775 EKSGINDVYNFKTFGQSMILLFQMSTSAGWDGVLDAIINEEACDPPDNDKGYPG-NCGSATVGIT 1838

Zfish  1666 YFVSFIFLCSFLMLNLFVAVIMDNFEYLTRDASI-LGPHHLDEFIRVWAEYDPAACGRMSYLDMY 1729
            :.:|::.:...:::|:::|||::|:...|.|... |.....|.:..:|.::||.....:.|..:.
  Fly  1839 FLLSYLVISFLIVINMYIAVILENYSQATEDVQEGLTDDDYDMYYEIWQQFDPEGTQYIRYDQLS 1903

Zfish  1730 EMLRHMSPPLGLGKKCPPRIAYKRLVRMNMPIAEDNTVHFTSTLMALIR 1778
            |.|..:.|||.:.|  |.:  || ::.|::||...:.::....|.||.:
  Fly  1904 EFLDVLEPPLQIHK--PNK--YK-IISMDIPICRGDLMYCVDILDALTK 1947

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
cacna1bbXP_021324711.1 Ion_trans 87..359 CDD:306908 89/301 (30%)
Ion_trans 487..726 CDD:306908 86/385 (22%)
Ion_trans 1115..1404 CDD:306908 102/299 (34%)
Ion_trans 1447..1698 CDD:306908 83/257 (32%)
GPHH 1699..1769 CDD:318993 18/70 (26%)
Ca_chan_IQ 1771..1845 CDD:312334 3/8 (38%)
Transformer <2074..>2135 CDD:253769
THRAP3_BCLAF1 2109..>2285 CDD:317794
paraNP_001259619.1 Ion_trans 165..436 CDD:278921 81/281 (29%)
Na_trans_cytopl 515..648 CDD:288761 19/132 (14%)
Ion_trans 835..1028 CDD:278921 67/206 (33%)
Na_trans_assoc 1054..1296 CDD:284034 65/396 (16%)
Ion_trans 1318..1571 CDD:278921 93/282 (33%)
Na_channel_gate 1561..1613 CDD:240441 11/52 (21%)
Ion_trans 1636..1871 CDD:278921 79/239 (33%)
GPHH 1880..1930 CDD:293510 15/54 (28%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG2301
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
32.810

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