DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PROS1 and crb

DIOPT Version :9

Sequence 1:	NP_001301006.1	Gene:	PROS1 / 5627	HGNCID:	9456	Length:	708	Species:	Homo sapiens
Sequence 2:	NP_001247284.1	Gene:	crb / 42896	FlyBaseID:	FBgn0259685	Length:	2253	Species:	Drosophila melanogaster

Alignment Length:	713	Identity:	161/713 - (22%)
Similarity:	261/713 - (36%)	Gaps:	203/713 - (28%)

- Green bases have known domain annotations that are detailed below.

Human    86 LERECI---EELCNKEEAREVFEND------PETDYFYPKYLVCLRSFQTGLFTAARQSTNAYPD 141
            ::.:|:   .::|| :.|.:..:|.      |..||    ...|.|.: ||
  Fly   703 VQNQCLCPENKVCN-QCATQPCQNGGECVDLPNGDY----ECKCTRGW-TG-------------- 747

Human   142 LRSCVNAIPDQCS--PLPCNEDGYMSCKDGKASFTCTCKPGWQGEKCEFDINECKDPSNINGGCS 204
             |:|.|.: |:|:  |..|   |...||:.|.|:.|.|.||:.|..|:.|::||.....:||.
  Fly   748 -RTCGNDV-DECTLHPKIC---GNGICKNEKGSYKCYCTPGFTGVHCDSDVDECLSFPCLNGA-- 805

Human   205 QICDNTPGSYHCSCKNGFVMLSNKKDCK-DVDECSLKPSICGTA--------VCKNIP------- 253
             .|.|...:|.|.|:.|:    ..::|: |:|||...|...|:.        .|..||
  Fly   806 -TCHNKINAYECVCQPGY----EGENCEVDIDECGSNPCSNGSTCIDRINNFTCNCIPGMTGRIC 865

Human   254 ----------------------GDFECECP-EGYRYNLKSKSCE-DIDECSENMCAQ--LCVNYP 292
                                  |.|.|:|. .||    :.::|| :||||..|.|..  .|::..
  Fly   866 DIDIDDCVGDPCLNGGQCIDQLGGFRCDCSGTGY----EGENCELNIDECLSNPCTNGAKCLDRV 926

Human   293 GGYTCYC-DGKKGFKLAQDQKSCE-----VVSVCLPLNLDTKYELLYLAEQFAGVVLYLKFRLPE 351
            ..|.|.| :|.||....||...||     ....||..:..|.|::..:.:            ||:
  Fly   927 KDYFCDCHNGYKGKNCEQDINECESNPCQYNGNCLERSNITLYQMSRITD------------LPK 979

Human   352 ISRFSAEFDFRT---YDS---EGVILYAESIDHSAWLLIALRGGKIEVQLKNEHTSKITTGGDVI 410
            :  ||..|.|..   |:.   .|:|                 |...|:.: ||..|...:.....
  Fly   980 V--FSQPFSFENASGYECVCVPGII-----------------GKNCEINI-NECDSNPCSKHGNC 1024

Human   411 NNGLWNMVSVEELEHSISIKIAKEAVMDINKPGPLFKPENGLLETKV------YFAGFPRKVESE 469
            |:|:.....  |.|........:..:.:.::..|.   :.|....::      ..|.:..|..|.
  Fly  1025 NDGIGTYTC--ECEPGFEGTHCEINIDECDRYNPC---QRGTCYDQIDDYDCDCDANYGGKNCSV 1084

Human   470 LIKPINPRLDGCIRSWNLMKQGASGIKEIIQEKQNKH-CLVTVEKGSYYPG---------SGIAQ 524
            |:|       ||  ..|....|.:.:..:|.|..:.: |  |.|.|  :.|         |.:|.
  Fly  1085 LLK-------GC--DQNPCLNGGACLPYLINEVTHLYNC--TCENG--FQGDKCEKTTTLSMVAT 1136

Human   525 FHIDYNNVSSAEGWHVNVTLNIRPSTGTGVMLALVSG--NNTVPFAVSLVDSTSEKSQDILLSVE 587
            ..|.. .....||:.:|  |..|.:...||:....:|  |..|.:.:.|::........:|...|
  Fly  1137 SLISV-TTEREEGYDIN--LQFRTTLPNGVLAFGTTGEKNEPVSYILELINGRLNLHSSLLNKWE 1198

Human   588 NTVIYRIQALSLCSDQQSHLEF-RVNRNNLELSTPLKIETISHEDLQRQLAV-----LDKAMKAK 646
            ...|.     |..:|...|..| .:|.::|.||.         .|.|....|     .:.:..:.
  Fly  1199 GVFIG-----SKLNDSNWHKVFVAINTSHLVLSA---------NDEQAIFPVGSYETANNSQPSF 1249

Human   647 VATYLGG-LPDVPF---SATPVNAFYNGCM-EVNINGVQLDLDE-----AISKHNDIRAHSCP 699
            ..||||| :|::..   ..|...:.:.||| ::.:||..:..||     :.:|..:::: .||
  Fly  1250 PRTYLGGTIPNLKSYLRHLTHQPSAFVGCMQDIMVNGKWIFPDEQDANISYTKLENVQS-GCP 1311

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PROS1	NP_001301006.1	GLA	58..117	CDD:214503	8/39 (21%)
		EGF_CA	151..187	CDD:238011	14/37 (38%)
		Plasmod_Pvs28	166..325	CDD:283826	58/206 (28%)
		FXa_inhibition	200..231	CDD:291342	8/30 (27%)
		EGF_CA	233..273	CDD:284955	15/77 (19%)
		FXa_inhibition	279..314	CDD:291342	12/37 (32%)
		Laminin_G_1	361..491	CDD:278483	23/141 (16%)
		Laminin_G_2	546..679	CDD:280389	32/145 (22%)
crb	NP_001247284.1	LamG	91..228	CDD:238058
		EGF_CA	386..423	CDD:238011
		EGF_CA	425..460	CDD:238011
		EGF	466..495	CDD:278437
		EGF	605..633	CDD:278437
		EGF_CA	716..750	CDD:238011	11/54 (20%)
		EGF_CA	753..789	CDD:238011	14/39 (36%)
		EGF_CA	792..828	CDD:238011	11/42 (26%)
		EGF_CA	830..865	CDD:238011	9/34 (26%)
		EGF_CA	868..905	CDD:238011	6/40 (15%)
		EGF_CA	907..943	CDD:238011	13/35 (37%)
		EGF_CA	1009..1045	CDD:238011	7/38 (18%)
		EGF_CA	1047..1082	CDD:238011	4/37 (11%)
		Laminin_G_1	1155..1290	CDD:278483	33/148 (22%)
		EGF	1316..1346	CDD:278437
		Laminin_G_1	1388..1550	CDD:278483
		EGF_CA	<1593..1622	CDD:238011
		Laminin_G_2	1692..1828	CDD:280389
		EGF_CA	1901..1937	CDD:238011
		EGF_CA	1939..1974	CDD:238011
		EGF_CA	2057..2094	CDD:238011
		EGF_CA	2096..2133	CDD:238011
		EGF_CA	2137..2175	CDD:238011
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910