DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment PROS1 and CG12951

DIOPT Version :9

Sequence 1:	NP_001301006.1	Gene:	PROS1 / 5627	HGNCID:	9456	Length:	708	Species:	Homo sapiens
Sequence 2:	NP_649880.1	Gene:	CG12951 / 41110	FlyBaseID:	FBgn0037677	Length:	265	Species:	Drosophila melanogaster

Alignment Length:	189	Identity:	43/189 - (22%)
Similarity:	69/189 - (36%)	Gaps:	58/189 - (30%)

- Green bases have known domain annotations that are detailed below.

Human   558 LVSGNNT----VPFAVSLVDSTSEKSQDILLSVENTVIYR--IQALSLCSDQQ--SHLEFRVNRN 614
            :|:|.::    .||.|||      :|.|...|...::|.:  :...:.|::.:  ..|..:....
  Fly    30 VVNGTDSSVLKYPFVVSL------RSYDGSHSCGGSIISKHFVMTAAHCTNGRPADTLSIQFGVT 88

Human   615 NLELSTPLKI---ETISHEDLQ--RQLA------------VLDKAMKAKVATYLGGLPDVPFSAT 662
            |:....|..:   :.|.|||..  ||.|            ..|....|.|.     ||.:.| |.
  Fly    89 NISAMGPNVVGIKKIIQHEDFDPTRQNANDISLLMVEEPFEFDGVSVAPVE-----LPALAF-AV 147

Human   663 P--------------VNAFYNGCMEVNINGVQLDL---DEAISKHN---DIRAHSCPSV 701
            |              :|..| |.::..:..|.|.:   :|..|:||   |.:.|.|..|
  Fly   148 PQSDAGVEGVLIGWGLNDTY-GSVQDTLQEVSLKIYSDEECTSRHNGQTDPKYHICGGV 205

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PROS1	NP_001301006.1	GLA	58..117	CDD:214503
		EGF_CA	151..187	CDD:238011
		Plasmod_Pvs28	166..325	CDD:283826
		FXa_inhibition	200..231	CDD:291342
		EGF_CA	233..273	CDD:284955
		FXa_inhibition	279..314	CDD:291342
		Laminin_G_1	361..491	CDD:278483
		Laminin_G_2	546..679	CDD:280389	33/159 (21%)
CG12951	NP_649880.1	Tryp_SPc	29..257	CDD:214473	43/189 (23%)
CG12951	NP_649880.1	Tryp_SPc	30..260	CDD:238113	43/189 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910