DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment PROS1 and Ser8

DIOPT Version :9

Sequence 1:	NP_001301006.1	Gene:	PROS1 / 5627	HGNCID:	9456	Length:	708	Species:	Homo sapiens
Sequence 2:	NP_610874.1	Gene:	Ser8 / 36489	FlyBaseID:	FBgn0019928	Length:	260	Species:	Drosophila melanogaster

Alignment Length:	166	Identity:	43/166 - (25%)
Similarity:	68/166 - (40%)	Gaps:	29/166 - (17%)

- Green bases have known domain annotations that are detailed below.

Human   556 LALVSGNNTVPFAVSLVDSTSEKSQDILLSVENTVIYRIQALSLCSDQQSHLEF---RVNRNNLE 617
            |||::..|.....:.|...||.....|:....:::..|...:||   |:|...|   .:..||:
  Fly     9 LALLALTNGAVIPIGLEPQTSSLGGRIVGGTASSIEDRPWQVSL---QRSGSHFCGGSIISNNI- 69

Human   618 LSTPLKIETISHEDLQRQLAVLDKAMKA--KVATYLGGLPDVPFSATPVNAFYNGCMEVNINGV- 679
                  |.|.:| .|.....|.:..::|  ...||.|.|.:|  :|...:..||...::|..||
  Fly    70 ------IVTAAH-CLDTPTTVSNLRIRAGSNKRTYGGVLVEV--AAIKAHEAYNSNSKINDIGVV 125

Human   680 ----QLDLD---EAISKHNDIRAH-SCPSV--WKKT 705
                :|...   :||:..:...|| |..|:  |.||
  Fly   126 RLKTKLTFGSTIKAITMASATPAHGSAASISGWGKT 161

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PROS1	NP_001301006.1	GLA	58..117	CDD:214503
		EGF_CA	151..187	CDD:238011
		Plasmod_Pvs28	166..325	CDD:283826
		FXa_inhibition	200..231	CDD:291342
		EGF_CA	233..273	CDD:284955
		FXa_inhibition	279..314	CDD:291342
		Laminin_G_1	361..491	CDD:278483
		Laminin_G_2	546..679	CDD:280389	31/127 (24%)
Ser8	NP_610874.1	Tryp_SPc	34..253	CDD:214473	36/141 (26%)
Ser8	NP_610874.1	Tryp_SPc	35..253	CDD:238113	36/140 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910