DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PROS1 and Lrp4

DIOPT Version :9

Sequence 1:	NP_001301006.1	Gene:	PROS1 / 5627	HGNCID:	9456	Length:	708	Species:	Homo sapiens
Sequence 2:	NP_727914.1	Gene:	Lrp4 / 32552	FlyBaseID:	FBgn0030706	Length:	2009	Species:	Drosophila melanogaster

Alignment Length:	887	Identity:	159/887 - (17%)
Similarity:	260/887 - (29%)	Gaps:	376/887 - (42%)

- Green bases have known domain annotations that are detailed below.

Human    79 EETKQGNLEREC----IEELCNKEEAREVFENDPETDYFYPKYLVCLRSFQTGLF---TAARQST 136
            ||....||:|:|    |..:|            |.|.....||.:|......|.:   |.....|
  Fly   213 EEDAVPNLQRDCEKTGIHVMC------------PRTFRCISKYWLCDGDDDCGDYSDETHCGART 265

Human   137 NAYPDLRSCVN--AIP-----------------DQCSPLPCNE------DGYM-----------S 165
            |...|...|:|  .||                 ..|:...|.:      |||.           .
  Fly   266 NCTDDQFECLNGFCIPRTWVCDGENDCKDFSDETHCNRTTCTDEHFTCNDGYCISLAFRCDGEHD 330

Human   166 CKDGKASFTCT------------CKPGWQGE------------KCEFDINECKDPSN-------- 198
            |.|......|.            |:.|..|.            :|:.| |:|.|.|:
  Fly   331 CNDNSDELKCAAVINSCPEGEFKCRGGLGGAGGPSGQCILNRFRCDGD-NDCGDWSDEENCPQKP 394

Human   199 ----------INGGC---------SQICDN----------------TPGSYHCSCKNGFVML--- 225
                      .:|.|         .|.||.                |.||...:|.||..:|
  Fly   395 SLCTSNEYKCADGTCIPKRWKCDKEQDCDGGEDENDCGSLGSEHPLTCGSDEFTCNNGRCILKTW 459

Human   226 --------------------------------------------------------SNKKDCKDV 234
                                                                    .::.||...
  Fly   460 LCDGYPDCAAGEDEVECHLQCDLGQFLCPTKQNLTNLKICVHQKHICDGHNECPAGEDEADCPKE 524

Human   235 DECSLKPSICGTAVCKNIPGDFECECPEGYRYNLKSKSCEDIDEC---SENMCAQLCVNYPGGYT 296
            .:|| :||.|.....:...|..||.|..||..:....:|.|||||   :..:|:|.|.|..|.:.
  Fly   525 RKCS-EPSPCEQLCIETTAGSNECACRLGYVMDKNKVNCTDIDECQYLTSPVCSQKCHNTMGSFK 588

Human   297 CYCDGKKGFKLAQDQKSCEVVSVCLPLNLDTKYELLYLA---EQFAGVVLYLKFRLPEISRFSAE 358
            |.|:  .|:.|..|.:||:.:...:.|.:..::::..:.   .:::.:|..|.      :..:.:
  Fly   589 CSCE--TGYILRPDLRSCKALGGAMTLLVANRWDIRRVTLSNNRYSAIVKGLH------NAIALD 645

Human   359 FDFRTYDSEGVILYAESIDHSAWLLIALRGGKIEVQLKNEHTSKITTGGDVINNGL--------- 414
            |..|    :|::.::: :......::.:.|.::.               |||..||
  Fly   646 FHHR----KGLMFWSD-VSTDVIKMVYMNGTRVR---------------DVIKWGLESPGGIAVD 690

Human   415 -------W-----NMVSVEELEHSISIKIAKEAVMDINKP-----------------GPLFKPE- 449
                   |     ..|.|...:.::...||.   .|::||                 ||..|.|
  Fly   691 WIHDLLFWTDSGTRRVEVSNFQGNLRTVIAS---YDLDKPRAIVVHPGEALAFWSDWGPNPKIER 752

Human   450 -------------------NGLL----ETKVYFAGFPRKVESELIKPINPRLDGCIRS------- 484
                               |||.    .:|:|:|    ..:...|:..|  |||..|:
  Fly   753 AYMDGTQRKVIISKGVTWPNGLAIDFPNSKIYWA----DAKQHAIECSN--LDGSDRNKILSTHL 811

Human   485 -----------------WNLMKQGASGI---KEIIQEKQNKHCLVTVEKGSYYPG---------- 519
                             ||.....|:..   ||.....:|.|..:.:.  :|:|.
  Fly   812 PHPFALTLFEDTMYWTDWNTKTVSAADKITGKEFRAVHENFHFPMDIH--AYHPARQPEYADRCQ 874

Human   520 -------SGIAQFHIDYNNVSSAEGWHVNVTLNIRPST--GTGVMLALVSGNNTVPFAVSLVDST 575
                   .|.:...:. |..|...|..:.::|.....|  .|...|.||:....:... .|.|:.
  Fly   875 KDRRGLRGGCSHLCLP-NKTSRRCGCPIGLSLKEDGKTCKSTADKLVLVARRKDIRLR-HLRDNQ 937

Human   576 SEKSQ-DILLSVENTVIYRIQALSLCSD--------------QQSHL----EFRVNRNNLELSTP 621
            ::.:. |:::.::|  :....||..|||              .::||    :.||..:||.....
  Fly   938 ADPNDVDMIVPLDN--LKHAVALDWCSDTDFIYWTDVERSTINKAHLNGSYQQRVVHSNLVSPVG 1000

Human   622 L-----------------KIETISHEDLQRQLAVLDKAMKAK 646
            |                 :||..:.....|.|.:.:|..|.:
  Fly  1001 LALDWITDKLYWTDPSTNRIEVATTNGKMRTLLIWEKLYKPR 1042

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PROS1	NP_001301006.1	GLA	58..117	CDD:214503	10/41 (24%)
		EGF_CA	151..187	CDD:238011	11/76 (14%)
		Plasmod_Pvs28	166..325	CDD:283826	56/287 (20%)
		FXa_inhibition	200..231	CDD:291342	12/114 (11%)
		EGF_CA	233..273	CDD:284955	11/39 (28%)
		FXa_inhibition	279..314	CDD:291342	11/37 (30%)
		Laminin_G_1	361..491	CDD:278483	34/215 (16%)
		Laminin_G_2	546..679	CDD:280389	27/139 (19%)
Lrp4	NP_727914.1	LDLa	267..301	CDD:238060	5/33 (15%)
		LDLa	306..340	CDD:238060	6/33 (18%)
		LDLa	347..390	CDD:238060	9/43 (21%)
		LDLa	397..431	CDD:238060	5/33 (15%)
		LDLa	442..476	CDD:238060	6/33 (18%)
		LDLa	480..521	CDD:238060	0/40 (0%)
		FXa_inhibition	576..604	CDD:291342	10/29 (34%)
		LY	634..671	CDD:214531	5/47 (11%)
		NHL	<656..793	CDD:302697	24/159 (15%)
		LY	680..714	CDD:214531	5/33 (15%)
		NHL repeat	681..722	CDD:271320	6/43 (14%)
		NHL repeat	726..760	CDD:271320	6/33 (18%)
		LY	761..803	CDD:214531	11/47 (23%)
		NHL repeat	769..793	CDD:271320	6/27 (22%)
		FXa_inhibition	882..912	CDD:291342	5/30 (17%)
		LY	946..985	CDD:214531	8/40 (20%)
		NHL	<967..1142	CDD:302697	13/76 (17%)
		LY	988..1030	CDD:214531	7/41 (17%)
		NHL repeat	998..1037	CDD:271320	5/38 (13%)
		NHL repeat	1038..1080	CDD:271320	1/5 (20%)
		NHL repeat	1084..1119	CDD:271320
		FXa_inhibition	1185..1220	CDD:291342
		NHL	1260..>1445	CDD:302697
		NHL repeat	1260..1296	CDD:271320
		NHL repeat	1302..1337	CDD:271320
		NHL repeat	1345..1383	CDD:271320
		FXa_inhibition	<1499..1525	CDD:291342
		LY	1600..1640	CDD:214531
		LY	1643..1686	CDD:214531
		LY	1688..1729	CDD:214531
		FXa_inhibition	1801..>1825	CDD:291342
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910