Protein Alignment MEPCE and bin3

DIOPT Version :10

• Sequence 1: NP_062552.2
• Gene: MEPCE / 56257
• HGNCID: 20247
• Length: 689
• Species: Homo sapiens
• Sequence 2: NP_523626.2
• Gene: bin3 / 35552
• FlyBaseID: FBgn0263144
• Length: 1367
• Species: Drosophila melanogaster
• Alignment Length: 1137
• Identity: 273/1137 - (24%)
• Similarity: 379/1137 - (33%)
• Gaps: 491/1137 - (43%)

Human     2 IEMAAEKEPFLVPAPP------PPLKDESGGGGGPTVPP--------HQEAASGELRGGTERGPG 52
            ::..:.:||  :|..|      .|.|.:|     ||..|        ||..|..:.:|...|...
  Fly    25 LDQTSRQEP--LPQQPDNGPAAAPGKSKS-----PTPLPGKSQAAQHHQFRAPQQQQGPKNRNKA 82

Human    53 ---RCAPSAG--SPAAAVGRESPGAAATSSS-------GPQAQQHR----------------GGG 89
               |...:.|  :|:|.||..|..|.:|.||       ...|..|:                |||
  Fly    83 WSKRQHKAGGKHNPSACVGASSGQAQSTGSSVIAATLLPTAASAHKADLENIQNIHNKNLTAGGG 147

Human    90 PQAQSHGEARLSDPPGRAAPPDVGEERRGGGGTELGPPAPPRPRNGYQPHR------------PP 142
              ...||.|              |....||||   |..|......|:..|.            ..
  Fly   148 --VNHHGNA--------------GTAHHGGGG---GAGAHHAAAGGHHHHHNTRLAQNAAAGGAS 193

Human   143 GGG-------------------GGKRRNSC---------NVGG-------------GGGG----- 161
            |||                   |....::|         ::||             ||||
  Fly   194 GGGTIQMHKKMLRGHHHHVLCAGNNANHTCCLVTGCNGSSIGGVGVAGSGGATASAGGGGASCKE 258

Human   162 ----------------------------------FKHPAFKRRRRVNSDCDSVLPSNFLLGGNIF 192
                                              |..|..:.|:.|     .|.|:.|||||||.
  Fly   259 AQSCKDTSSLSGNSSIAGSAGAGNAVHYCCGRSKFFLPEKRLRKEV-----IVPPTKFLLGGNIS 318

Human   193 DPLNLNSLLDEEVSRTLN-----AETPKSSPL--PAKGRDPVEILIPKDITDPLSLNTCTD--EG 248
            ||||||||.:|..|...:     |.||:.||:  |.|    ||::||.:|.|||.|....|  |.
  Fly   319 DPLNLNSLQNENTSNASSTNNTPATTPRQSPITTPPK----VEVIIPPNIHDPLHLLDPVDSMEY 379

Human   249 HVVLASPLKT-----GRKRHRHRGQHHQQQQA--------------AG-----GSESHPVPP--- 286
            ...|.||:|.     |...||   |||.:.:.              ||     |||....||
  Fly   380 EKQLTSPMKRAGPGGGMLHHR---QHHYRTRKNRKRRRFDSNNTSHAGDEGGVGSELTDEPPLPA 441

Human   287 ----------TAPLT---PLLHGEGASQQP---RHRGQNR------------------DAPQPYE 317
                      .|||.   .||..|.|:..|   ...||.:                  :.|.|..
  Fly   442 ATSSLAASPVAAPLNVGGSLLLSESAAPAPGETAEMGQQQEQAHVHSPQSASTTTTAAEMPTPTP 506

Human   318 LN----TAINCRDEVVSPLPSALQGP-------------------SGSLSAPPAASVISAPPSSS 359
            .:    ||.....|..:|.|:|...|                   |.:...|....::|...:|:
  Fly   507 TSAAAATATAEHKEQSAPAPTATSSPQRQQQHVAAAAEELPTPETSAAAETPAEEMLLSCSATSA 571

Human   360 S------RHRKRRRT---------------------SSKSEAGARGGGQGSKEK---GRGSWGGR 394
            |      ..|:..|.                     |..|..|:..||.|.|.|   ...|...:
  Fly   572 SLVASTLAERRASRDLRLDLSSTCYGVGGTGLSFGGSISSSVGSSFGGGGRKRKISESSTSQKSK 636

Human   395 HHHHH-----------PLPAA-------------------------------------------- 404
            ..|.|           |.|.|
  Fly   637 KFHRHDAMDKIVSPVVPQPGAWKRPPRILQPSGARKPSTRRSTSVSESELLSPVEEQPPKQLPLI 701

Human   405 ----------------------------------------------------------------- 404
                                                                             
  Fly   702 GVEIPRDDTPDLPDHGLGSPLSTTSGATSHTAGEQDSLAGVDISMGDTLGSGVVGKAPLTSSLML 766

Human   405 ------------GFKKQQRKFQYGNYCKYYGYRNPS-CEDGRLRVLK--PEWFRGRDVLDLGCNV 454
                        .|:....|::|||:.:|..:|..: ..|.||:|.:  .|.|..:|:||:||||
  Fly   767 EPAKIPPIKMLPKFRADGLKYRYGNFDRYVDFRQMNEFRDVRLQVFQRHVELFENKDILDIGCNV 831

Human   455 GHLTLSIACKWGPSRMVGLDIDSRLIHSARQNIRHYLSEELRLPPQ----TLEGDP--------- 506
            ||:|:::|....|..:||:|||..|:..||:|    ||..:|:|.:    .::.:|
  Fly   832 GHMTITVARHLAPKTIVGIDIDRELVARARRN----LSIFVRIPKEEKLLEVKAEPTVDAKANIA 892

Human   507 ------GAEGEEGTTTVRKRSC---------------------------------FPAS--LTAS 530
                  ||..::.....|:|..                                 ||.|  ||..
  Fly   893 VKDETSGAAHKKTRRGKRRRKVHQGIHHHHHHHHDLEQLQQQQKLNSLLVKPHEFFPISFPLTYG 957

Human   531 RGP--IAAPQVPLDGADTSVFPNNVVFVTGNYVLDRDDLVEAQTPEYDVVLCLSLTKWVHLNWGD 593
            |.|  :::.:.|....:.:.||.||.|...||||..:.|:.:.|.:||::||||:|||:|||:||
  Fly   958 RIPRILSSSKSPNMLGNKNQFPANVFFRHTNYVLKDESLMASDTQQYDLILCLSVTKWIHLNFGD 1022

Human   594 EGLKRMFRRIYRHLRPGGILVLEPQPWSSYGKRKTLTETIYKNYYRIQLKPEQFSSYLTSPDVGF 658
            .|||..|:|::..|||||.|:||.|.|:||.|:|.||..||.||.:|:..|.:|..||.|.:|||
  Fly  1023 NGLKMAFKRMFNQLRPGGKLILEAQNWASYKKKKNLTPEIYNNYKQIEFFPNKFHEYLLSSEVGF 1087

Human   659 SSYELVATPHNTSKGFQRPVYLFHKA-RSPSH 689
            |....:..|.:.:|||.||:.|:.|. .:|:|
  Fly  1088 SHSYTLGVPRHMNKGFCRPIQLYAKGDYTPNH 1119

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MEPCE	NP_062552.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..167		56/298 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	258..314		23/116 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	332..407		24/255 (9%)
		Tam	443..616	CDD:443282	74/228 (32%)
		Bin3	575..683	CDD:462022	56/107 (52%)
bin3	NP_523626.2	PRK07764	<426..>559	CDD:236090	25/132 (19%)
		Cfa	783..>862	CDD:441831	31/78 (40%)
		Tam	824..>864	CDD:443282	20/43 (47%)
		Bin3	1004..1112	CDD:462022	56/107 (52%)