DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CRTAM and crtam

DIOPT Version :9

Sequence 1:	NP_062550.2	Gene:	CRTAM / 56253	HGNCID:	24313	Length:	393	Species:	Homo sapiens
Sequence 2:	XP_005172764.1	Gene:	crtam / 101884219	-ID:	-	Length:	436	Species:	Danio rerio

Alignment Length:	376	Identity:	119/376 - (31%)
Similarity:	181/376 - (48%)	Gaps:	71/376 - (18%)

- Green bases have known domain annotations that are detailed below.

Human    23 TETITVEEGQTLTLKCV-TSLRKNSSLQWLTPSGFTIFLNEYPALKNSKYQLLHHSANQLSITVP 86
            |:.|.|.||.||.|||. .:|..|..::| ...|..:|.|.:..||:.:..|...::.:.::.|.
Zfish    25 TKFIAVVEGDTLVLKCPRRNLSDNVHMEW-RKEGHVMFFNTHKGLKDPRINLFTSNSFEFTVVVS 88

Human    87 NVTLQDEGVYKCLHYSDSVSTKEVKVIVLATPFKPILEASVIRKQNGEEH---VVLMCSTMRSKP 148
            |||.:|||:|:|..|.|.||||..||.||.:|           |.:..||   .|:.|:|..:..
Zfish    89 NVTFKDEGLYRCFVYEDQVSTKRFKVKVLGSP-----------KIDMTEHEGKAVIKCTTAANGH 142

Human   149 PPQITWLLGNSMEVSGGTLHEFETDGKKCNTTSTLIIHTYGKNSTVDCIIRHRGLQGRKL----- 208
            ||:::|.:| .:||........|....:....|.|.|.|:.:.:||.|:.:||.||.:.:
Zfish   143 PPKLSWQIG-GVEVEAVPNTWLEERSNRTFAVSILTIKTHIREATVKCLAKHRELQNKVMNFIII 206

Human   209 -----------VAPFRFEDLVTDEETASDALERNSLSSQDPQQPTST-----VSVTEDSSTSEID 257
                       :...| :||.|  ||...|.....:||..|.:.:|.     |..|||:::..|.
Zfish   207 QNHSIISSTTSIYSTR-DDLKT--ETMITATSPPVISSTTPVELSSISESTGVFATEDTTSKSIQ 268

Human   258 KEEKEQTTQDPDLTT------EANP--------------------QYLGLARKKSGILLLTLVSF 296
            .|| ..|..|..|||      |:|.                    ||   .:|||..||:.||:.
Zfish   269 VEE-HSTEFDISLTTHDITSSESNSTDGFLTNNSTNIQDDGDKDRQY---NQKKSSPLLILLVTT 329

Human   297 LIFILFIIVQLFIMKLRKAHVIWKKENEVSEHTLESYRSRSNNEETSSEEK 347
            ||..|.|:|..|:::|||.|:.||||||.|:.::||.:|::::||..:.::
Zfish   330 LIICLLIVVIFFLIRLRKTHIAWKKENEESDQSVESSKSKASHEEKQAHDR 380

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CRTAM	NP_062550.2	Ig	20..114	CDD:299845	36/91 (40%)
		IG_like	24..114	CDD:214653	35/90 (39%)
		Ig	121..207	CDD:299845	24/88 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	225..273		17/58 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	328..354		5/20 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	374..393
		PDZ-binding. /evidence=ECO:0000250\|UniProtKB:Q149L7	390..393
crtam	XP_005172764.1	Ig	23..116	CDD:325142	36/91 (40%)
crtam	XP_005172764.1	Ig	130..198	CDD:325142	20/68 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C194325724
Domainoid	1	1.000	71	1.000	Domainoid score	I31824
eggNOG	1	0.900	-	-		E1_2A8SS
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H10454
Inparanoid	1	1.050	148	1.000	Inparanoid score	I11669
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG42572
OrthoDB	1	1.010	-	-		D247622at7742
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		oto44042
orthoMCL	1	0.900	-	-		OOG6_120364
Panther	1	1.100	-	-	LDO	PTHR47118
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R11291
SonicParanoid	1	1.000	-	-		X10064
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	15	14.840