DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment BTNL2 and tutl

DIOPT Version :9

Sequence 1:	NP_001291490.1	Gene:	BTNL2 / 56244	HGNCID:	1142	Length:	482	Species:	Homo sapiens
Sequence 2:	NP_001303307.1	Gene:	tutl / 46015	FlyBaseID:	FBgn0010473	Length:	1536	Species:	Drosophila melanogaster

Alignment Length:	376	Identity:	82/376 - (21%)
Similarity:	133/376 - (35%)	Gaps:	121/376 - (32%)

- Green bases have known domain annotations that are detailed below.

Human    18 FILLTM-----KQSEDFRVIGPAHPILAGVGEDALLTCQL-LPKRTTMHVEVRWYRSEPST---- 72
            |:|:::     |.::...:...|..|.|.:||..:..|.: .|....:...::|.:....|
  Fly   113 FVLVSLLALLAKNAQAHNIPEDAVHITAILGEGVIFNCHVEFPNDHPVPYVLQWDKKVSETGSDL 177

Human    73 PVFV----HRDGVEVTEMQMEEYRGWVEWIENGIAKGNVALKIHNIQPSDNGQYWCHFQDGNYCG 133
            |:::    :.:.:|      |.|:|.|..:......|:.:|.:.||:.||.|.|.|
  Fly   178 PIYIWYESYPEHIE------EGYKGRVSRVSQDSPFGSASLNLTNIRESDQGWYEC--------- 227

Human   134 ETSLLLKVAGLGSAPSIHMEGP------------------------GESGVQLVCTARGWFPEPQ 174
                  ||..|...|..|..|.                        |:| :.|.|.|.| .|.|:
  Fly   228 ------KVVFLNRDPKQHKNGTWFHLDVHAPPRFSVTPEDIIYVNLGDS-IILNCQADG-TPTPE 284

Human   175 VYW-EDIR-------------GEKLLAVSEHRIQDKDGLFYAEATLVVRNASAESVSCLVHNPVL 225
            :.| :|..             |.: |.:|..|.:|     ..|.|.:.||...:    :.|...:
  Fly   285 ILWYKDANPVDPSPTVGIFNDGTE-LRISTIRHED-----IGEYTCIARNGEGQ----VSHTARV 339

Human   226 TEEKGSVISLPEKLQTELASLKVNGPSQPILVRVGEDIQLTCYLSPKANAQSMEVRWDRSHRYPA 290
            ....|:||.:|...||:|.               ||.:..:|  ..||...::.|||
  Fly   340 IIAGGAVIMVPPTNQTKLE---------------GEKVIFSC--EAKAMPGNVTVRW-------- 379

Human   291 VHVYMDGDHVAGEQMAEYRGRTVLVSDAIDEGRLTLQILSARPSDDGQYRC 341
               |.:|..|  .::|....|..:..|.      :|.|...:|.|.|||.|
  Fly   380 ---YREGSPV--REVAALETRVTIRKDG------SLIINPIKPDDSGQYLC 419

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
BTNL2	NP_001291490.1	IG_like	37..141	CDD:214653	23/112 (21%)
		Ig_MOG_like	43..142	CDD:143190	22/107 (21%)
		Ig	148..229	CDD:299845	23/118 (19%)
		IG_like	252..358	CDD:214653	22/90 (24%)
		Ig_MOG_like	260..358	CDD:143190	22/82 (27%)
tutl	NP_001303307.1	V-set	137..250	CDD:284989	29/133 (22%)
		IG_like	137..229	CDD:214653	23/112 (21%)
		I-set	253..341	CDD:254352	20/99 (20%)
		IGc2	268..331	CDD:197706	19/70 (27%)
		I-set	346..437	CDD:254352	28/110 (25%)
		Ig	349..437	CDD:299845	26/107 (24%)
		Ig	459..530	CDD:299845
		IG_like	549..628	CDD:214653
		IGc2	551..617	CDD:197706
		FN3	633..725	CDD:238020
		FN3	786..874	CDD:238020
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910