Protein Alignment SUSD2 and mesh

DIOPT Version :10

• Sequence 1: NP_062547.1
• Gene: SUSD2 / 56241
• HGNCID: 30667
• Length: 822
• Species: Homo sapiens
• Sequence 2: NP_001163782.1
• Gene: mesh / 43688
• FlyBaseID: FBgn0051004
• Length: 1454
• Species: Drosophila melanogaster
• Alignment Length: 820
• Identity: 246/820 - (30%)
• Similarity: 362/820 - (44%)
• Gaps: 129/820 - (15%)

Human    51 LGTCCLDFRDFCLEI--LPYSGSMMGGK---------DFVVRHFKMSSPTDASVICRFKDSIQTL 104
            :|:|..|.....|.:  .|.||:|:||:         |..:|           |.|.| |:...|
  Fly   428 IGSCNKDIDAALLPLTFAPESGNMLGGQVVNITGPCFDPAIR-----------VTCHF-DTESVL 480

Human   105 GHVDSSGQVHCVSPLLYESGRIPFTVSLDNGHSFPRAGTWLAVHP----NKV-----SMMEKSEL 160
            |......:|.||.|.|...|.|.|.:|:.. ..|...|.:....|    .|:     .:.:|:..
  Fly   481 GTYVDRNRVICVQPYLKAEGYIRFQISVGT-QRFKWRGKYFVETPAAATEKIFFTTDDVHKKNPA 544

Human   161 VNETRW-QYYGTANTSGNLSLTWHVKSLPTQTITIELWGYEETGMPYSQEWTAKWSYLYPLATHI 224
            .....| ||..|:|.:.|              :.|.||||.||.:....|      |:..:....
  Fly   545 EIRITWNQYNLTSNANAN--------------VMISLWGYRETKIEPQLE------YIDVIEASY 589

Human   225 PNSGSFTFTPKPAPPSY-------QRWRVGALRI--IDSKNYAGQKDVQALWTNDHALAWHLSDD 280
            .||||:..||.    :|       :..:.|.|:|  .....|:|......||:....|||:::..
  Fly   590 SNSGSYVITPS----NYINRNNINRDMQFGFLQINLTQPDQYSGLAISPVLWSRPIPLAWYMAPQ 650

Human   281 F-REDPVAWARTQCQAWEELEDQLPNFLEELPDCPCTLTQARADSGRFFTDYGCDMEQGSVCTYH 344
            : |:....|||..|..|...:..|.||..:||.|||||.||..|.|||..|..||.:....|..|
  Fly   651 WERQHGKRWARALCDNWIRADRFLRNFAADLPLCPCTLDQAVLDKGRFRPDRECDKDSNPSCLRH 715

Human   345 PGAVHCVRSVQASLRYGSGQQCCYTADGTQLLTADSSGGSTPDRGHDWGAPPFRTPPRVPSMSHW 409
            .||:|||.| ...:..|:.|||||...|..:||.|...||.|.|.|:.|..|:....:|||:|.|
  Fly   716 RGAIHCVVS-GTPVAQGAEQQCCYDRYGFLMLTYDQMWGSRPRRVHNLGKMPWNEASKVPSLSMW 779

Human   410 LYDVLSFYYCCLW----APDCPRY-MQRRPSNDCRNYRPPRLASAFGDPHFVTFDGTNFTFNGRG 469
            .:|:..||.||.|    |..|..| .:||||.||..|:.|.:|..||||||||||||.:||||.|
  Fly   780 FHDMRPFYSCCYWQEEQAVGCETYRFERRPSQDCVAYQAPGIAGVFGDPHFVTFDGTAYTFNGLG 844

Human   470 EYVLLEAA--LTDLRVQARAQPGTMSNGTETRGTGLTAVAVQEGNSDVVEVRL----ANRTGGLE 528
            |:||..:.  .....||.|.:...::...|.:.|.|||||::...:..:||||    |.....|:
  Fly   845 EFVLARSVDESNKFEVQGRFEQLPVNYYGEVKATQLTAVAMRGNTTTTIEVRLRPLHARWRYRLD 909

Human   529 VLLNQEVLSFTEQS--WMDLKGMFLSVAA----GDRVSIMLASGAGLEVSVQGPFLSVSVLLPEK 587
            ||.:...:.|..:|  :....|:.:....    ..:|.:...:|.|:||.....:::..|.||.|
  Fly   910 VLADGRRVYFDRESLKFQHFDGVTVYTPTYLLNQSQVVVQFDAGIGVEVVENEGYMTGRVFLPWK 974

Human   588 FLTHTHGLLGTLNNDPTDDFTLHSGRVLPPGTSPQELFL---------FGANWTVHN------AS 637
            |:..|.||.|..:.:..|||.|.:|:|       .:|.|         ||..|.:.:      .:
  Fly   975 FINKTAGLFGNWSFNKLDDFMLPNGQV-------AQLNLNDLRSIHTNFGIKWMLTDREVPGVGA 1032

Human   638 SLLTYD----SWFLVHNFLYQPKH--DPTFEPLFPSETTLNPSLAQEAAKLCGDDHFCNFDVAAT 696
            :|...:    |.:.. |..:||.:  ||.  ...|:..:.:...|:|   |||:...|.:|.|.|
  Fly  1033 ALFKREFGRMSGYYA-NATFQPNYVLDPA--DFLPANRSYDLERAEE---LCGECMQCQYDYAMT 1091

Human   697 GSLSTGTATRVAHQ-LHQRRMQSLQPVVSCGWLAPPPNGQKEGNRYLAGSTIYFHCDNGYSLAGA 760
            .:......|:..:. :...:.::...|||||.|..|..|:|....::.|:.:.|.|:.|:.|.|.
  Fly  1092 LNRDLAHFTKNYYDTIVNMQAENAVRVVSCGVLQTPRFGRKLSFDFMPGAKVSFECNEGFILIGD 1156

Human   761 ETSTCQADGTWSSPT---PKCQPGRSYA-----VLLGIIF 792
            :...|.::|.|:.|.   .:|.....|.     :.:||||
  Fly  1157 QRRECLSNGLWNIPEYGYTECLREVYYTRRVAFIAIGIIF 1196

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SUSD2	NP_062547.1	Somatomedin_B	29..64	CDD:460034	3/12 (25%)
		AMOP	289..429	CDD:461048	61/143 (43%)
		VWD	448..613	CDD:459671	59/176 (34%)
		CCP	725..779	CDD:153056	16/56 (29%)
mesh	NP_001163782.1	NIDO	259..419	CDD:214712
		TIG	446..511	CDD:460355	23/77 (30%)
		AMOP	660..803	CDD:461048	61/143 (43%)
		VWD	811..999	CDD:214566	64/187 (34%)
		CCP	1121..1171	CDD:214478	15/49 (31%)