DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SUSD2 and susd2

DIOPT Version :9

Sequence 1:	NP_062547.1	Gene:	SUSD2 / 56241	HGNCID:	30667	Length:	822	Species:	Homo sapiens
Sequence 2:	XP_031748710.1	Gene:	susd2 / 105946288	XenbaseID:	XB-GENE-5887491	Length:	1591	Species:	Xenopus tropicalis

Alignment Length:	801	Identity:	428/801 - (53%)
Similarity:	547/801 - (68%)	Gaps:	33/801 - (4%)

- Green bases have known domain annotations that are detailed below.

Human     3 PALLPWALLLLATALGPGPGPTADAQESCSMRCGALDGPCSCHPTCSGLGTCCLDFRDFCLEILP 67
            ||||...:.||...|   |...:.|.||||.:||.....||||.||..|.|||.|:..||:.|.|
Frog     2 PALLLICIGLLTLTL---PPEVSGASESCSSQCGERLQSCSCHTTCQKLQTCCTDYHQFCISISP 63

Human    68 YSGSMMGGKDFVVRHFKMSSPTDASVICRFKDSIQTLGHVDSSGQVHCVSPLLYESGRIPFTVSL 132
            :||::||||||::.:...|  .::::||||.:...|.|:||::|..||:||||.|:|||..|||.
Frog    64 HSGTLMGGKDFIILNLTFS--PNSTIICRFNNETNTEGYVDAAGIAHCISPLLLETGRISLTVSQ 126

Human   133 DNGHSFPRAGTWLAVHPNKVSMMEKSELVNETRWQYYGTANTSGNLSLTWHVKSLPTQTITIELW 197
            |.||:|.|:|||||||.:|.|:.|||..::..:||||||...:|.|||.|:.|:||::.|:||:|
Frog   127 DGGHNFTRSGTWLAVHHSKASVAEKSVQLDSKKWQYYGTPGYNGTLSLIWNAKTLPSENISIEVW 191

Human   198 GYEETGMPYSQEWTAKWSYLYPLATHIPNSGSFTFTPKPAPPSYQRWRVGALRIIDSKNYAGQKD 262
            ||.|||.|||..|.|.|.|||.||...||||:|||||.||...|.:|.||.||||.|....||.:
Frog   192 GYSETGTPYSDTWRADWKYLYTLAPTYPNSGTFTFTPSPAEAPYNQWDVGMLRIIPSDKPHGQMN 256

Human   263 VQALWTNDHALAWHLSDDFREDPVAWARTQCQAWEELE-DQLPNFLEELPDCPCTLTQARADSGR 326
            |.|:|:..|||||||.:.||.|..|||..:|.:|.:.| :.|||||:|.|||||||.|||||:||
Frog   257 VHAIWSPVHALAWHLEESFRNDSAAWASDKCISWRDAEINALPNFLKETPDCPCTLDQARADTGR 321

Human   327 FFTDYGCDMEQGSVCTYHPGAVHCVRSVQASLRYGSGQQCCYTADGTQLLTADSSGGSTPDRGHD 391
            :.||||||:|:||||||||||||||||:|||.:|.|||||||.:.|.|:||.||:||||||||||
Frog   322 YHTDYGCDIEKGSVCTYHPGAVHCVRSIQASPQYASGQQCCYDSTGAQVLTFDSTGGSTPDRGHD 386

Human   392 WGAPPFRTPPRVPSMSHWLYDVLSFYYCCLWAPDCPRYMQRRPSNDCRNYRPPRLASAFGDPHFV 456
            ||:||:|.|||||..|||:|||::|||||||:.:|..||..|||:|||.|:||:.||.|||||||
Frog   387 WGSPPYRKPPRVPGFSHWMYDVVTFYYCCLWSDNCQYYMDLRPSSDCRTYKPPKAASGFGDPHFV 451

Human   457 TFDGTNFTFNGRGEYVLLEAALTDLRVQAR------AQPGTMSNG--------------TETRGT 501
            ||||:.:||||:|||.|:.::...|.:|||      .:|.|.:.|              :|....
Frog   452 TFDGSKYTFNGKGEYTLVSSSHKSLSIQARTKAFTVTKPDTGNFGQINAEIHFDDRADRSEVHAA 516

Human   502 GLTAVAVQEGNSDVVEVRLANRTG-GLEVLLNQEVLSFTEQSWMDLKGMFLSVAAGDRVSIMLAS 565
            ||.:||:||.:|||:|||:.:.:. .||.||||||:||.|||||||.|:|:..|....|::|..|
Frog   517 GLCSVAMQEDDSDVIEVRVKDGSSHELETLLNQEVISFEEQSWMDLVGVFVYSAISSNVTVMFPS 581

Human   566 GAGLEVSVQGPFLSVSVLLPEKFLTHTHGLLGTLNNDPTDDFTLHSGRVLPPGTSPQELFLFGAN 630
            |||:||..:..||||:||||:.|:..|.||||.:||:|.||||..:|..|||..:|.|||..||:
Frog   582 GAGIEVRRREDFLSVNVLLPDDFMNQTQGLLGVMNNNPADDFTFRNGTSLPPNATPVELFQLGAD 646

Human   631 WTVHNASSLLTYDSWFLVHNFLYQPKHDPTFEPLFPSETTLNPSLAQEAAKLCGDDHFCNFDVAA 695
            |.|.|.|||.||||..|::|  ...|||.||:|.|..|.  |||  :...:|||||.||.||..|
Frog   647 WAVTNESSLFTYDSQELINN--SHVKHDHTFQPTFSFEE--NPS--EPLLELCGDDEFCRFDGLA 705

Human   696 TGSLSTGTATRVAHQLHQRRMQSLQPVVSCGWLAPPPNGQKEGNRYLAGSTIYFHCDNGYSLAGA 760
            |..|:...||:::..:|...:::|:|.|||||:|||.||:|.|..|||||.:.|.|:.|:.:.|.
Frog   706 TYDLNVANATKISFLVHSNLVKNLKPEVSCGWIAPPENGEKIGTTYLAGSVVQFKCNAGFIMNGT 770

Human   761 ETSTCQADGTWSSPTPKCQPG 781
            :..||..|||||....:|..|
Frog   771 KLRTCLPDGTWSGDAAQCLVG 791

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SUSD2	NP_062547.1	Somatomedin_B	29..64	CDD:279385	19/34 (56%)
		GPI-anchored	180..256	CDD:287331	45/75 (60%)
		AMOP	289..430	CDD:281737	98/141 (70%)
		VWD	448..613	CDD:295339	89/185 (48%)
		CCP	725..779	CDD:153056	26/53 (49%)
susd2	XP_031748710.1	Somatomedin_B	25..58	CDD:395820	17/32 (53%)
		AMOP	283..426	CDD:397723	99/142 (70%)
		VWD	443..629	CDD:413350	89/185 (48%)
		CCP	735..788	CDD:153056	26/52 (50%)
		Somatomedin_B	794..827	CDD:395820
		AMOP	1052..1193	CDD:397723
		VWD	1200..1374	CDD:413350
		CCP	1487..1541	CDD:153056
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	268	1.000	Domainoid score	I10846
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
NCBI	1	1.000	-	-
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D296951at33208
OrthoFinder	1	1.000	-	-		FOG0007412
OrthoInspector	1	1.000	-	-		oto157178
Panther	1	1.100	-	-	LDO	PTHR13802
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X5542
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	7.110