Protein Alignment PROC and ea

DIOPT Version :10

• Sequence 1: XP_024308771.1
• Gene: PROC / 5624
• HGNCID: 9451
• Length: 556
• Species: Homo sapiens
• Sequence 2: NP_524362.2
• Gene: ea / 41858
• FlyBaseID: FBgn0000533
• Length: 392
• Species: Drosophila melanogaster
• Alignment Length: 275
• Identity: 89/275 - (32%)
• Similarity: 127/275 - (46%)
• Gaps: 47/275 - (17%)

Human   306 RLIDGKMTRRGDSPWQVVL----LDSKKKLACGAVLIHPSWVLTAAHCMDESKKLL-------VR 359
            |:..|..|:..:.||..::    ...||...||..||...:|:||:||:: .|.|.       ||
  Fly   127 RIYGGMKTKIDEFPWMALIEYTKSQGKKGHHCGGSLISTRYVITASHCVN-GKALPTDWRLSGVR 190

Human   360 LGEYDLRRWEKWE-------------LDLDIKEVFVHPNYSKSTTD--NDIALLHLAQPATLSQT 409
            |||:|.......|             ||:.::....||:|..::.:  ||||||.|||....:..
  Fly   191 LGEWDTNTNPDCEVDVRGMKDCAPPHLDVPVERTIPHPDYIPASKNQVNDIALLRLAQQVEYTDF 255

Human   410 IVPICLP-DSGLAERELNQAGQETLVTGWGYHSSREKEAKRNRTFVLNFIKIPVVPHNECSEVMS 473
            :.||||| |..|  |.....|....|.|||..........:.:..|..|      ..:||..|.|
  Fly   256 VRPICLPLDVNL--RSATFDGITMDVAGWGKTEQLSASNLKLKAAVEGF------RMDECQNVYS 312

Human   474 N---MVSENMLCAGILG-DRQDACEGDSGGPMVA----SFHGTWFLVGLVSWG-EGCGLLHNYGV 529
            :   ::.:..:|||  | :..|:|.||||||::.    ..:..:||.|:||:| ..|||....||
  Fly   313 SQDILLEDTQMCAG--GKEGVDSCRGDSGGPLIGLDTNKVNTYYFLAGVVSFGPTPCGLAGWPGV 375

Human   530 YTKVSRYLDWIHGHI 544
            ||.|.:|:|||...|
  Fly   376 YTLVGKYVDWIQNTI 390

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PROC	XP_024308771.1	GLA	85..148	CDD:214503
		EGF_CA	162..193	CDD:238011
		FXa_inhibition	235..270	CDD:464251
		Tryp_SPc	308..543	CDD:238113	87/270 (32%)
ea	NP_524362.2	CLIP	37..89	CDD:463440
		Tryp_SPc	128..389	CDD:238113	87/271 (32%)