Protein Alignment PROC and ndl

DIOPT Version :10

• Sequence 1: XP_024308771.1
• Gene: PROC / 5624
• HGNCID: 9451
• Length: 556
• Species: Homo sapiens
• Sequence 2: NP_523947.2
• Gene: ndl / 38738
• FlyBaseID: FBgn0002926
• Length: 2616
• Species: Drosophila melanogaster
• Alignment Length: 586
• Identity: 148/586 - (25%)
• Similarity: 233/586 - (39%)
• Gaps: 137/586 - (23%)

Human    20 TASTQGQPFHSASTWGCRQSSSGGRHCPELRSPPQTGASASRMWQLTSLLLFVATWGISGTPAPL 84
            ||:.|||..:::.....:|.......|||   |.|......:.      .:..|.|        .
  Fly   865 TANQQGQIIYASYAGLPQQPIQERSRCPE---PDQFSCFGQQE------CIPAARW--------C 912

Human    85 DSVFSSSERAHQVLRIRKRANSFLEELRHSSLERECIEEICD-FEE----------------AKE 132
            |:|...|:.:              :|...:..:|...|.:|| :|:                |..
  Fly   913 DNVVDCSDGS--------------DESACTCADRVDEERLCDGYEDCPMGEDELGCFGCESLAYS 963

Human   133 IFQNVDD-------TLAF-WSK--HVDG-DQCLVLPLEHPCASLC------CGHG-TCIDGI--- 176
            .::|..|       |::. :|:  ..|| ..||....|..|:.|.      ..|| :..:|.
  Fly   964 CYENPQDFAKRNRSTISMCYSRLERCDGFMNCLNGRDEEQCSMLVTDVADHMSHGASASEGYLYH 1028

Human   177 ---GSFSCDCRSG--WEGRFCQRGEGERWMLAGGGAGLGPGWGRGTSTSCPRPPLPAEVSFLNCS 236
               |.:...|.:|  |....||..|..|   ....|.|...:   .:.:.|.|       |:..|
  Fly  1029 NYRGDWHPVCNNGEKWAALACQMDENSR---MDHSASLNVSF---QTLTLPGP-------FIEPS 1080

Human   237 LDNGGCTHYCLEEVGWRRCSCAPGYKLGDDLLQCHPAVKFP---CGRPWK-RMEKKRSHLKRDTE 297
            |..|  .|:.      :.|.   |....|.|:.....||.|   ||.|.| .|.:....::|...
  Fly  1081 LHAG--VHFA------QACH---GRNSHDSLVDHVAYVKCPPMQCGLPSKSSMLEHSKRVRRAVS 1134

Human   298 DQEDQV-DPRLIDGKMTRRGDSPWQVVLLDSKKKLACGAVLIHPSWVLTAAHCMDESKKLLVRLG 361
            |.::.| |.|::.|..|.....|: ||.:....|..||..:....|:::||||       ::..|
  Fly  1135 DSKEIVGDGRIVGGSYTSALQWPF-VVAIYRNGKFHCGGTIYSDRWIISAAHC-------VINYG 1191

Human   362 EY------DLRRWEKWELDLDIK---EVFVHPNYSKSTTDNDIALLHLAQPATLSQTIVPICLPD 417
            :|      .|.|...:.....|:   .|.||..|.:.:..||::||.|..|...::.:.||||||
  Fly  1192 KYFYEVRAGLLRRSSYSPATQIQPVSHVVVHQAYERRSMRNDLSLLRLLNPLQFNRWVKPICLPD 1256

Human   418 SG---LAERELNQAGQETL--VTGWGYHSSREKEAKRNRTFVLNFIKIPVVPHNECSEVMSNMVS 477
            .|   :.:..:....:.||  |.|||  :.|||....:   .:..:.:|:  ..:|:: ..:..|
  Fly  1257 KGRTTVGDDWIWGPVEHTLCTVVGWG--AIREKGPSSD---PMRQVIVPI--RKKCTD-PEDQAS 1313

Human   478 ENMLCAGILGDRQDACEGDSGGPMV---ASFHGTWFLVGLVSWGEGCGLLHNYGVYTKVSRYLDW 539
            |: :|||.....:|||:||||||:.   .|....::|.|:||.|.||.....:||||:|:.||||
  Fly  1314 ED-ICAGDPDGGRDACQGDSGGPLFCRSVSNPDEFYLAGVVSHGNGCARPQEFGVYTRVTLYLDW 1377

Human   540 I 540
            :
  Fly  1378 L 1378

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PROC	XP_024308771.1	GLA	85..148	CDD:214503	14/89 (16%)
		EGF_CA	162..193	CDD:238011	9/45 (20%)
		FXa_inhibition	235..270	CDD:464251	8/34 (24%)
		Tryp_SPc	308..543	CDD:238113	77/250 (31%)
ndl	NP_523947.2	LDLa	891..927	CDD:238060	11/66 (17%)
		Tryp_SPc	1145..1379	CDD:238113	77/251 (31%)
		LDLa	1399..1430	CDD:238060
		LDLa	1710..1743	CDD:238060
		LDLa	1776..1811	CDD:238060
		DUF1986	2041..2158	CDD:286432
		LDLa	2309..2339	CDD:197566
		LDLa	2350..2383	CDD:197566
		LDLa	2421..2457	CDD:238060