Protein Alignment PROC and CG6462

DIOPT Version :10

• Sequence 1: XP_024308771.1
• Gene: PROC / 5624
• HGNCID: 9451
• Length: 556
• Species: Homo sapiens
• Sequence 2: NP_648011.1
• Gene: CG6462 / 38681
• FlyBaseID: FBgn0035663
• Length: 319
• Species: Drosophila melanogaster
• Alignment Length: 293
• Identity: 82/293 - (27%)
• Similarity: 130/293 - (44%)
• Gaps: 56/293 - (19%)

Human   291 HLKRDTEDQED-----------------------------QVDPRLIDGKMTRRGDSPWQ---VV 323
            |.|.:|.|.:|                             .|..|:..|::..||..|:|   |:
  Fly    32 HPKEETPDDDDAIMERRWQLGYENFRLRCEKFEMEGNQTAAVRTRIAGGELATRGMFPYQVGLVI 96

Human   324 LLDSKKKLACGAVLIHPSWVLTAAHCMDESKKLLVRLGEYDLRRWEK--WELDLDIKEVFVHPNY 386
            .|.....:.||..||...:|||||||:.::....:..|.......|.  .||.:..::..::|:|
  Fly    97 QLSGADLVKCGGSLITLQFVLTAAHCLTDAIAAKIYTGATVFADVEDSVEELQVTHRDFIIYPDY 161

Human   387 SKSTTDNDIALLHLAQPATLSQTIVPICLPDSGLAERELNQAGQETLVTGWGY-HSSREKEAKRN 450
            ......:|:||:.|.:....|:.:.||.|....:.:..|  .|:...::|||| ..|.:|
  Fly   162 LGFGGYSDLALIRLPRKVRTSEQVQPIELAGEFMHQNFL--VGKVVTLSGWGYLGDSTDK----- 219

Human   451 RTFVLNFIKIPVVPHNEC-SEVMSNMVSENM-LCA-GILGDRQDACEGDSGGPMVASFHGTWFLV 512
            ||.:|.::...|:....| ...:..:||:.. ||. |..|  :.||.||||||:|..:....:|:
  Fly   220 RTRLLQYLDAEVIDQERCICYFLPGLVSQRRHLCTDGSNG--RGACNGDSGGPVVYHWRNVSYLI 282

Human   513 GLVSWG--EGCGLLHNYG---VYTKVSRYLDWI 540
            |:.|:|  |||    ..|   |||:::.||.||
  Fly   283 GVTSFGSAEGC----EVGGPTVYTRITAYLPWI 311

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PROC	XP_024308771.1	GLA	85..148	CDD:214503
		EGF_CA	162..193	CDD:238011
		FXa_inhibition	235..270	CDD:464251
		Tryp_SPc	308..543	CDD:238113	75/247 (30%)
CG6462	NP_648011.1	Tryp_SPc	77..314	CDD:238113	75/248 (30%)