Protein Alignment PROC and CG12133

DIOPT Version :10

• Sequence 1: XP_024308771.1
• Gene: PROC / 5624
• HGNCID: 9451
• Length: 556
• Species: Homo sapiens
• Sequence 2: NP_610540.2
• Gene: CG12133 / 36036
• FlyBaseID: FBgn0033469
• Length: 340
• Species: Drosophila melanogaster
• Alignment Length: 336
• Identity: 94/336 - (27%)
• Similarity: 140/336 - (41%)
• Gaps: 78/336 - (23%)

Human   255 CSCAP-GYKLGDDLLQCHPAV---KFP----CGRPWKRMEKKRSHLKRDTEDQEDQVDPRLIDGK 311
            |:..| .::|...:..|.|.|   |.|    ||:     ....|::....|.|.:|.
  Fly    22 CNINPFAHELVHMVFTCCPMVAGDKLPDSRVCGQ-----SPPSSYIVGGMEAQSNQF-------- 73

Human   312 MTRRGDSPWQVVL----LDSKKKLA--CGAVLIHPSWVLTAAHCMDESKKLL--VRLGEYDLRR- 367
                   ||.|:|    ..:|::.:  |...||...:|||||||::.:...:  |||||:|...
  Fly    74 -------PWTVLLGYEAYTAKQRPSPMCAGSLIASRYVLTAAHCLNVNDFYVARVRLGEHDTEND 131

Human   368 ------------WEKWELDLDIKEVFVHPNY--SKSTTDNDIALLHLAQPATLSQTIVPICL-PD 417
                        |....:|:|:.....|..|  ......||||||.|......:..|.|||: |
  Fly   132 PDYTWLPNGAKIWAPAHVDIDVDLRVPHEQYYTRNGRHYNDIALLRLKSRVKYTLQIRPICIWP- 195

Human   418 SGLAERELNQAGQETL---VTGWGYHSSREKEAKRNRTFVLNFIKIPVVPHNECSEVMSNMVSEN 479
             |:   ||:.:..:..   :.|||....::|..      ||....|..:..:||......::.:.
  Fly   196 -GI---ELSTSSFKNFPFQIAGWGDSGLQQKST------VLRQGTISGMSPDECLNRYPTLLVDK 250

Human   480 --MLCAGILG-DRQDACEGDSGGPMVASF-HGT---WFLVGLVSWGEGCGLLHNYG--VYTKVSR 535
              .:||  :| |..|...||||.|::||. .|.   ::|.|:.|:|.|.. .:.||  ||||.|.
  Fly   251 DIQICA--MGWDGTDTGLGDSGSPLMASVGRGADQFYYLAGITSYGGGPS-SYGYGPAVYTKTSS 312

Human   536 YLDWIHGHIRD 546
            |.:||...|.|
  Fly   313 YYEWIKKKIND 323

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PROC	XP_024308771.1	GLA	85..148	CDD:214503
		EGF_CA	162..193	CDD:238011
		FXa_inhibition	235..270	CDD:464251	3/15 (20%)
		Tryp_SPc	308..543	CDD:238113	78/270 (29%)
CG12133	NP_610540.2	Tryp_SPc	62..317	CDD:214473	79/283 (28%)