Protein Alignment PROC and CG8170

DIOPT Version :10

• Sequence 1: XP_024308771.1
• Gene: PROC / 5624
• HGNCID: 9451
• Length: 556
• Species: Homo sapiens
• Sequence 2: NP_610441.2
• Gene: CG8170 / 35908
• FlyBaseID: FBgn0033365
• Length: 855
• Species: Drosophila melanogaster
• Alignment Length: 361
• Identity: 96/361 - (26%)
• Similarity: 143/361 - (39%)
• Gaps: 77/361 - (21%)

Human   217 TSTSCPRPPLPAEVSFLNCSLDNG-----------GCTHYCLEEVGWRRCSCAPGYKLGD----- 265
            |.|.|.......|. ||.|.|..|           ||.|           ..|....||.
  Fly   525 TDTECQHRGGTCEF-FLGCWLSGGLIQGTCDGLLRGCCH-----------RTAKSANLGSSDFVG 577

Human   266 ------DLLQCH--PAVKFP-CGRPWKRMEKKRSHLKRDTEDQEDQVDPRLIDGKMTRRGDSPWQ 321
                  ||.|.:  |....| ||....:...:|                |::.|.....|..|||
  Fly   578 NAVDLTDLPQKNYGPVNNEPSCGISLAKQTAQR----------------RIVGGDDAGFGSFPWQ 626

Human   322 VVLLDSKKKLACGAVLIHPSWVLTAAHCMDES--KKLLVRLGEYDLRRWEK--WELDLDIKEVFV 382
            ..:.....:  ||..||....|:||.||:..:  :::.|.||:|.:....:  ......::.:.|
  Fly   627 AYIRIGSSR--CGGSLISRRHVVTAGHCVARATPRQVHVTLGDYVINSAVEPLPAYTFGVRRIDV 689

Human   383 HPNYSKSTTDN---DIALLHLAQPATLSQTIVPICLPDSGLAERELNQAGQETLVTGWGYHSSRE 444
            || |.|.|...   ||::|.|.:.......|.|||||     |:..:..|:.....|||    ..
  Fly   690 HP-YFKFTPQADRFDISVLTLERTVHFMPHIAPICLP-----EKNEDFLGKFGWAAGWG----AL 744

Human   445 KEAKRNRTFVLNFIKIPVVPHNEC-----SEVMSNMVSENMLCAGILGDRQDACEGDSGGPMVAS 504
            ....|.|...|..:.:||:.:..|     ...::.::.:.|||||.....:|:|:||||||::..
  Fly   745 NPGSRLRPKTLQAVDVPVIENRICERWHRQNGINVVIYQEMLCAGYRNGGKDSCQGDSGGPLMHD 809

Human   505 FHGTWFLVGLVSWGEGCGLLHNYGVYTKVSRYLDWI 540
            .:|.|:|:|:||.|..|......|:|..||:.:||:
  Fly   810 KNGRWYLIGVVSAGYSCASRGQPGIYHSVSKTVDWV 845

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PROC	XP_024308771.1	GLA	85..148	CDD:214503
		EGF_CA	162..193	CDD:238011
		FXa_inhibition	235..270	CDD:464251	11/56 (20%)
		Tryp_SPc	308..543	CDD:238113	72/245 (29%)
CG8170	NP_610441.2	Tryp_SPc	612..846	CDD:238113	72/246 (29%)