Protein Alignment PROC and CG8172

DIOPT Version :10

• Sequence 1: XP_024308771.1
• Gene: PROC / 5624
• HGNCID: 9451
• Length: 556
• Species: Homo sapiens
• Sequence 2: NP_001097235.2
• Gene: CG8172 / 35905
• FlyBaseID: FBgn0033362
• Length: 561
• Species: Drosophila melanogaster
• Alignment Length: 571
• Identity: 138/571 - (24%)
• Similarity: 202/571 - (35%)
• Gaps: 227/571 - (39%)

Human    15 PSSALTASTQGQPFHSASTWGCRQ-------------SSSGGRHCPELRSPPQTGASAS-RMWQL 65
            ||::.|||:..:|.:.:|.:|.::             ||:||      .|.|.:.:|:| ..|:
  Fly   166 PSTSSTASSSARPAYPSSYYGTKRPTHYSGSNPYKPGSSAGG------SSRPSSSSSSSLNSWE- 223

Human    66 TSLLLFVATWG----ISGTPAPLDSVFSSSERAHQVLRIRKRANSFLEELRHSSLERECIEEICD 126
                  ..|.|    |||....|||.|.:..:|
  Fly   224 ------HETGGHLGSISGITNHLDSFFDAESQA-------------------------------- 250

Human   127 FEEAKEIFQNVDDTLAFWSKHVDGDQCLVLPLEHPCASLCCGHGTCIDGIGSFSCDCRSGWEGRF 191
                                          ||:
  Fly   251 ------------------------------PLD-------------------------------- 253

Human   192 CQRGEGERWMLAGGGAGLGPGWGRGTSTSCPRPPLPAEVSF-------LNC-----SLDNGGCTH 244
                          .||..|          |..|||...:|       ||.     ...:||...
  Fly   254 --------------SAGAPP----------PHEPLPNAQAFAVGNVLDLNAGEAADEYQSGGSGG 294

Human   245 YCLEEVGWRRCSCAPGYKLGDDLLQCHPAVKFPCGRPWKRMEKKRSHLKRDTEDQEDQVDPRLID 309
            |  .:..:|.   .||                 ||..:.|..                   |::.
  Fly   295 Y--HDASYRP---VPG-----------------CGEVYTRSN-------------------RIVG 318

Human   310 GKMTRRGDSPWQVVLLDS---KKKLACGAVLIHPSWVLTAAHCM--DESKKLLVRLGEYDLR--- 366
            |..|..|..||||.|:.|   .:||:||..||...||:|||||:  ..:..:.:||||:|:|
  Fly   319 GHSTGFGSHPWQVALIKSGFLTRKLSCGGALISNRWVITAAHCVASTPNSNMKIRLGEWDVRGQE 383

Human   367 -RWEKWELDLDIKEVFVHPNYSKSTTDNDIALLHLAQPATLSQTIVPICLPDSGLAERELNQAGQ 430
             |....|..::.||  |||:|:.:...||:||:.|.:.....|.|:|:|||.|     .....|:
  Fly   384 ERLNHEEYGIERKE--VHPHYNPADFVNDVALIRLDRNVVYKQHIIPVCLPPS-----TTKLTGK 441

Human   431 ETLVTGWGYHSSREKEAKRNRTFVLNFIKIPVVPHNECSEVM-----SNMVSENMLCAGILGDRQ 490
            ...|.|||    |.:..:.....||..:.:.|:.::.|....     ...:.:..||||.....:
  Fly   442 MATVAGWG----RTRHGQSTVPSVLQEVDVEVISNDRCQRWFRAAGRREAIHDVFLCAGYKDGGR 502

Human   491 DACEGDSGGPMVASFHGTWFLVGLVSWGEGCGLLHNYGVYTKVSRYLDWIH 541
            |:|:||||||:..:..|...|:||||||.|||..|..||||.:.|::.||:
  Fly   503 DSCQGDSGGPLTLTMDGRKTLIGLVSWGIGCGREHLPGVYTNIQRFVPWIN 553

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PROC	XP_024308771.1	GLA	85..148	CDD:214503	4/62 (6%)
		EGF_CA	162..193	CDD:238011	0/30 (0%)
		FXa_inhibition	235..270	CDD:464251	6/39 (15%)
		Tryp_SPc	308..543	CDD:238113	89/248 (36%)
CG8172	NP_001097235.2	Tryp_SPc	316..555	CDD:238113	89/249 (36%)