DRSC/TRiP Functional Genomics Resources

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Protein Alignment PROC and spirit

DIOPT Version :10

Sequence 1:XP_024308771.1 Gene:PROC / 5624 HGNCID:9451 Length:556 Species:Homo sapiens
Sequence 2:NP_572492.1 Gene:spirit / 31797 FlyBaseID:FBgn0030051 Length:393 Species:Drosophila melanogaster


Alignment Length:375 Identity:112/375 - (29%)
Similarity:171/375 - (45%) Gaps:78/375 - (20%)


- Green bases have known domain annotations that are detailed below.


Human   227 PAEVSFLNCSLDN-----GGCTHYCLEEV-----GW--RRCSCAPGYKLG-DDLLQCHPAVKFPC 278
            |.| :|..|.|::     |.|..  :|:.     ||  ||.|....|.:. |..:.|.|||    
  Fly    44 PVE-TFDECQLEDVARTKGTCRR--MEDCPSALNGWLERRESPKTCYFVRFDHYVCCAPAV---- 101

Human   279 GRP--WKRMEKKRSHLKRDTEDQE-DQVDPRLIDGKMTRRGDSPWQVVL-----LDSKKKLACGA 335
             .|  .:..::..:.|.:.::.:| |:....::.|..||..:.|:...|     .|.:....||.
  Fly   102 -APIVTRSSQQACNELNKVSKVKEIDEFFVSVVGGMPTRPREFPFMAALGWRSNFDQRIYYRCGG 165

Human   336 VLIHPSWVLTAAHCMD--ESKKLLVRLGEYDLRRWEKWELDLDIKEVFVHPNYSKSTTDNDIALL 398
            .||..::|||||||.|  ......||||..:|...|  ..|:.|:.|.:||:||.||..||||||
  Fly   166 ALIANNFVLTAAHCADLGGEPPSQVRLGGDNLTLTE--GEDISIRRVIIHPDYSASTAYNDIALL 228

Human   399 HLAQPATLSQTIVPICLPDSGLAERELNQAGQETLVTGWGYHSSREKEAKRNRTFV----LNFIK 459
            .|...|  ...:.|.|:    ..::|:.    .||||..||..:         :|.    ...:|
  Fly   229 ELETAA--KPELKPTCI----WTQKEVT----NTLVTAIGYGQT---------SFAGLSSAQLLK 274

Human   460 IPV--VPHNEC-----SEVMSNMVSENMLCAGILGDRQDACEGDSGGPMVASFHGTWFLVGLVSW 517
            :|:  |.:.||     .:.::..|....:|||.:...:|.|:||||||::.......::||:.|.
  Fly   275 VPLKSVSNEECQHHYQKDQLAQGVLGTQMCAGDITGERDTCQGDSGGPLLMQDGLLGYVVGITSL 339

Human   518 GEGCGLLHNYG---VYTKVSRYLDWIHGHI----RDKEAPQ----KSWAP 556
            |:||.    .|   |||:||.::|||.|.:    :...|||    .|::|
  Fly   340 GQGCA----SGPPSVYTRVSSFVDWIEGIVWPAQQVTNAPQPNQMTSFSP 385

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PROCXP_024308771.1 GLA 85..148 CDD:214503
EGF_CA 162..193 CDD:238011
FXa_inhibition 235..270 CDD:464251 12/47 (26%)
Tryp_SPc 308..543 CDD:238113 83/255 (33%)
spiritNP_572492.1 CLIP 51..98 CDD:197829 12/48 (25%)
Tryp_SPc 132..364 CDD:238113 83/256 (32%)
Blue background indicates that the domain is not in the aligned region.

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