DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment myo5aa and Mhc

DIOPT Version :9

Sequence 1:XP_017207607.1 Gene:myo5aa / 562188 ZFINID:ZDB-GENE-041027-2 Length:1854 Species:Danio rerio
Sequence 2:NP_001162991.1 Gene:Mhc / 35007 FlyBaseID:FBgn0264695 Length:1962 Species:Drosophila melanogaster


Alignment Length:2159 Identity:550/2159 - (25%)
Similarity:897/2159 - (41%) Gaps:577/2159 - (26%)


- Green bases have known domain annotations that are detailed below.


Zfish    16 WIPDDEEVWRSAEL--TKDYRQGDGVLQLQLEDGKDLEFKLDPKTNNLPHLRNPDILVGENDLTA 78
            ||||::|.:...|:  ||    || ::.:.|:.|:..:.|.: |...:    ||.......|:..
  Fly    39 WIPDEKEGYLLGEIKATK----GD-IVSVGLQGGEVRDIKSE-KVEKV----NPPKFEKIEDMAD 93

Zfish    79 LSYLHEPAVLHNLKVRFIDSKLIYTYCGIVLVAINPYETLPIYGADIINAYSGQNMGDMDPHIFA 143
            ::.|:.|.|||||:.|:. :||||||.|:..||||||:..|:|.......|.|:...::.|||||
  Fly    94 MTVLNTPCVLHNLRQRYY-AKLIYTYSGLFCVAINPYKRYPVYTNRCAKMYRGKRRNEVPPHIFA 157

Zfish   144 VAEEAYKQMARDERNQSIIVSGESGAGKTVSAKYAMRYFATVSGS-------ASEANVEEKVLAS 201
            :::.||..|..:..|||::::||||||||.:.|..:.|||||..|       .|:.::|::|:.:
  Fly   158 ISDGAYVDMLTNHVNQSMLITGESGAGKTENTKKVIAYFATVGASKKTDEAAKSKGSLEDQVVQT 222

Zfish   202 NPIMESIGNAKTTRNDNSSRFGKYIEIGFDKKYHIIGANMRTYLLEKSRVVFQADEERNYHIFYQ 266
            ||::|:.|||||.||||||||||:|.|.|.....:.||::.||||||:||:.|...||:||||||
  Fly   223 NPVLEAFGNAKTVRNDNSSRFGKFIRIHFGPTGKLAGADIETYLLEKARVISQQSLERSYHIFYQ 287

Zfish   267 LCASAHLPEFKALKLGKAN--DFHYTKQGRNPVIDGVDDAKEMSTTRNAFILLGINESYQMGLFQ 329
            : .|..:|..|.:.|...|  |:|...||: ..:..:|||:|.|.|..||.:||..:..:..:::
  Fly   288 I-MSGSVPGVKDICLLTDNIYDYHIVSQGK-VTVASIDDAEEFSLTDQAFDILGFTKQEKEDVYR 350

Zfish   330 ILASILHLGNVDVKDR------DSDSSIIPPNNGHLSVFCELMGVTYQDMSHWLCHKKLKTATET 388
            |.|:::|:|.:..|.|      :.|..   ...|.:|   :|.|....::...|...::|...|.
  Fly   351 ITAAVMHMGGMKFKQRGREEQAEQDGE---EEGGRVS---KLFGCDTAELYKNLLKPRIKVGNEF 409

Zfish   389 YIKPIPKLQAINARDALAKHIYAKLFNWIVDHVNKALHSTVKQHSFIGVLDIYGFETFEINSFEQ 453
            ..:.....|..|:..||.|.::.:||.|:|...|:.|.:..|:..|||||||.|||.||.|.|||
  Fly   410 VTQGRNVQQVTNSIGALCKGVFDRLFKWLVKKCNETLDTQQKRQHFIGVLDIAGFEIFEYNGFEQ 474

Zfish   454 FCINYANEKLQQQFNMHVFKLEQEEYMKEQIPWTLIDF-YDNQPCINLIEAKMGILDLLDEECKM 517
            .|||:.||||||.||.|:|.||||||.:|.|.|..||| .|...||:|||..||||.:|:||...
  Fly   475 LCINFTNEKLQQFFNHHMFVLEQEEYKREGIDWAFIDFGMDLLACIDLIEKPMGILSILEEESMF 539

Zfish   518 PKGSDDSWAQKLYNTHLKTCALFEKPRMSNKA-----FIIQHFADKVEYQCDGFLEKNKDTVNEE 577
            ||.:|.::::||.||||...|.|:||:.....     |.|.|:|..|.|...|:||||||.:|:.
  Fly   540 PKATDQTFSEKLTNTHLGKSAPFQKPKPPKPGQQAAHFAIAHYAGCVSYNITGWLEKNKDPLNDT 604

Zfish   578 QINVLKASKFDLLVELFHDEEKATSPTGAAPGPGGRTRLSVKPDKGKSSQASKEHKKTVGLQFRN 642
            .::..|.|:..||:|:|.|.  |....|.....|||         ||.....    .||...::.
  Fly   605 VVDQFKKSQNKLLIEIFADH--AGQSGGGEQAKGGR---------GKKGGGF----ATVSSAYKE 654

Zfish   643 SLQLLMETLNATTPHYVRCIKPNDYKHAFTFDPKRAVQQLRACGVLETIRISAAGFPSRWTYQEF 707
            .|..||.||.:|.||:||||.||:.|.....|....:.||...||||.|||...|||:|..|.:|
  Fly   655 QLNSLMTTLRSTQPHFVRCIIPNEMKQPGVVDAHLVMHQLTCNGVLEGIRICRKGFPNRMMYPDF 719

Zfish   708 FSRYRVLMKQ--KDVLTDKKMTCKNVLEKLVQDP-DKYQFGKTKIFFRAGQVAYLEKLRADKLRA 769
            ..||:::..:  :.|..|||.|  .::.|.:..| |:|:.|.||:|||||.:..:|:.|.::|  
  Fly   720 KMRYKIMCPKLLQGVEKDKKAT--EIIIKFIDLPEDQYRLGNTKVFFRAGVLGQMEEFRDERL-- 780

Zfish   770 ACIRIQKTIRCWLARKKYLRMKHAATTIQRFVRGYQARCLAKFLRRTRAAI-IIQKYQRMYIQKT 833
                  ..|..|:               |.:.|||.:|...|.|:..|.|: ::|:..|.|:|  
  Fly   781 ------GKIMSWM---------------QAWARGYLSRKGFKKLQEQRVALKVVQRNLRKYLQ-- 822

Zfish   834 CYKRKQAAALAMQCILRAYMARQLYKALLREHKAVIIQKMVRGWLARQWFK--RSLKAIVYLQCC 896
                                                    :|.|   .|:|  :.:|.::.:.  
  Fly   823 ----------------------------------------LRTW---PWYKLWQKVKPLLNVS-- 842

Zfish   897 IRRMRAKRELKKLKIEARSVEHFKKLNIGMENKIMQLQRR------------------IDDQNKE 943
                |.:.|:.:|:.:|:..|......:.:..::..|..:                  :.|..:.
  Fly   843 ----RIEDEIARLEEKAKKAEELHAAEVKVRKELEALNAKLLAEKTALLDSLSGEKGALQDYQER 903

Zfish   944 NRSMSERLNTLETSHAVESERMRAEVTRLRGAEEDAKNNA--------NKVTSLLEELERLRKDL 1000
            |..::.:.|.||.......||:.        .||||:|..        .:::.|.:::|.|..::
  Fly   904 NAKLTAQKNDLENQLRDIQERLT--------QEEDARNQLFQQKKKADQEISGLKKDIEDLELNV 960

Zfish  1001 QNTQKEKKAIEDWAQTYQDEM---EKMISELKEQNQLLKTEKNNLNQLIQEQSQQWTDKMQRALK 1062
            |..:::|...:...:...||:   :::|::|.::.::    :...||...|:.|...||:     
  Fly   961 QKAEQDKATKDHQIRNLNDEIAHQDELINKLNKEKKM----QGETNQKTGEELQAAEDKI----- 1016

Zfish  1063 EETQQLENDLNEERSRYQNLLTEHLRLEEKYDDLKEEITLAVNVPKPGHRRTDSTHSSNESECTY 1127
                   |.||:.::          :||:..|:|::.:                           
  Fly  1017 -------NHLNKVKA----------KLEQTLDELEDSL--------------------------- 1037

Zfish  1128 NSEFAESEEGSRVGEDVSKSILDMSLFLKL-QKRVSELEQEKQSLQNELDRREEQFQRARAR-DD 1190
                   |...:|..||.||...:...||| |:.|::||:.|:.|:..:.|::::.....|: :|
  Fly  1038 -------EREKKVRGDVEKSKRKVEGDLKLTQEAVADLERNKKELEQTIQRKDKELSSITAKLED 1095

Zfish  1191 EE-----HKK------ARGAELEYESLKRQELESENKKLKHDLNQMRQSLRGSVEAGSGAPGSPA 1244
            |:     |::      ||..|||.|....::..::.:|.:.||.:..:.|...:|...||  :.|
  Fly  1096 EQVVVLKHQRQIKELQARIEELEEEVEAERQARAKAEKQRADLARELEELGERLEEAGGA--TSA 1158

Zfish  1245 YTVL-------LDQLNASNEELEVRKEEVLI-LRSQLVSQKEAMQHKDEKTTMTEPLPYIEDVQK 1301
            ...|       |.:|....||..::.|..|. ||.         :|.|....|.|.:..:..: |
  Fly  1159 QIELNKKREAELSKLRRDLEEANIQHESTLANLRK---------KHNDAVAEMAEQVDQLNKL-K 1213

Zfish  1302 LTDAKEISQAYMGLKD--------TNRSPFPD------YHKLNEDGELWLVYEGLKETNRLL--- 1349
            ....||.::.|..|.|        ||.....:      .|.|||      |...|.||||.|   
  Fly  1214 AKAEKEKNEYYGQLNDLRAGVDHITNEKAAQEKIAKQLQHTLNE------VQSKLDETNRTLNDF 1272

Zfish  1350 ----------ESQLQAQRRSHDNEVEVLR----------GELHSLKEENNRQQQLLA---QNL-- 1389
                      .|.|..|....:::|..|.          .:...|.:|.:|::..|.   :||  
  Fly  1273 DASKKKLSIENSDLLRQLEEAESQVSQLSKIKISLTTQLEDTKRLADEESRERATLLGKFRNLEH 1337

Zfish  1390 -------QLPPEARIEASLQHEIT----------------------------------------- 1406
                   |:..||..:|.||.:::                                         
  Fly  1338 DLDNLREQVEEEAEGKADLQRQLSKANAEAQVWRSKYESDGVARSEELEEAKRKLQARLAEAEET 1402

Zfish  1407 ----------------RLTNENLDLMEQLEKQDKTVRKLKKQLKVFAK-------KINDLEGGQM 1448
                            ||:.|..||..::::.:......:|:.|.|.|       |::|| ..::
  Fly  1403 IESLNQKCIGLEKTKQRLSTEVEDLQLEVDRANAIANAAEKKQKAFDKIIGEWKLKVDDL-AAEL 1466

Zfish  1449 DVSPGQTADEPVHPVNIPRREKDFQGMLEYKKEDELKL---VKNIILELKPRGVAVNLIPGLPAY 1510
            |.|..:..:.......:....::.|..||..:.:...|   ||:::.::...|..::.|......
  Fly  1467 DASQKECRNYSTELFRLKGAYEEGQEQLEAVRRENKNLADEVKDLLDQIGEGGRNIHEIEKARKR 1531

Zfish  1511 I------LFMCLRHADYINDDQKVRSL-----LTSVINSIKKILKKRGDDFETVSFWLANT---- 1560
            :      |...|..|:...:.::.:.|     |:.|...|.:.::::.::||       ||    
  Fly  1532 LEAEKDELQAALEEAEAALEQEENKVLRAQLELSQVRQEIDRRIQEKEEEFE-------NTRKNH 1589

Zfish  1561 ------------------CRFLHCLKQYSGD----EQFMKHNSPKQNEHCLSNFDLAEYRQVLSD 1603
                              ...|...|:...|    |..:.| :.|.|.....|  :..|:|.|.|
  Fly  1590 QRALDSMQASLEAEAKGKAEALRMKKKLEADINELEIALDH-ANKANAEAQKN--IKRYQQQLKD 1651

Zfish  1604 L----------------AIQIYQQLIKCMENILQPMIVSGMLE----------------HETIQG 1636
            :                .:.|.::....::|.|:..  ..:||                ||.:..
  Fly  1652 IQTALEEEQRARDDAREQLGISERRANALQNELEES--RTLLEQADRGRRQAEQELADAHEQLNE 1714

Zfish  1637 VSGVKPTGLRKRTSSIADEGTYTLDSIIRQLNTFHSIMCHHGTDPELIKQV----VKQQFYIIGA 1697
            ||.        :.:||: .....|:|   :|.|.||.:      .||:.:.    .|.:..::.|
  Fly  1715 VSA--------QNASIS-AAKRKLES---ELQTLHSDL------DELLNEAKNSEEKAKKAMVDA 1761

Zfish  1698 VTLNNLL------------LRKDMCSWSKGMQIRYN-------------VSQLEEWLRD------ 1731
            ..|.:.|            |||.:....|.:|:|.:             :.:||:.:|:      
  Fly  1762 ARLADELRAEQDHAQTQEKLRKALEQQIKELQVRLDEAEANALKGGKKAIQKLEQRVRELENELD 1826

Zfish  1732 ----------KNLMTCGAK---------------ETLEPLI-QAAQLLQVKKKTDEDAEAICSMC 1770
                      |||.....:               |.::.|: :..|.::..|:..|:||.|.:: 
  Fly  1827 GEQRRHADAQKNLRKSERRVKELSFQSEEDRKNHERMQDLVDKLQQKIKTYKRQIEEAEEIAAL- 1890

Zfish  1771 NALSTAQIVKVLNLYTPVNAFEERVSVLFIRTIQTRLRDRKES---------------PQLLMDT 1820
                  .:.|.......:...|||..:......:.|.:.|..|               ||.   .
  Fly  1891 ------NLAKFRKAQQELEEAEERADLAEQAISKFRAKGRAGSVGRGASPAPRATSVRPQF---D 1946

Zfish  1821 KLIYPVTFPFNPSS 1834
            .|.:|..|...|.:
  Fly  1947 GLAFPPRFDLAPEN 1960

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
myo5aaXP_017207607.1 MYSc_Myo5 85..752 CDD:276831 281/690 (41%)
IQ 766..787 CDD:197470 3/20 (15%)
IQ 789..811 CDD:197470 5/21 (24%)
SMC_N <920..1279 CDD:330553 78/408 (19%)
SMC_N <1156..>1445 CDD:330553 88/422 (21%)
Myo5a_CBD 1480..1854 CDD:271262 84/503 (17%)
MhcNP_001162991.1 Myosin_N 36..73 CDD:280832 12/38 (32%)
MYSc 81..777 CDD:214580 290/721 (40%)
MYSc_Myh1_insects_crustaceans 100..765 CDD:276874 281/690 (41%)
Myosin_tail_1 842..1897 CDD:279860 212/1184 (18%)
V_Alix_like 1557..1877 CDD:187408 58/349 (17%)
ATP-synt_B <1671..1771 CDD:304375 23/119 (19%)
TMPIT 1739..>1825 CDD:285135 15/91 (16%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0000014
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
32.910

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