DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment cacna1aa and para

DIOPT Version :9

Sequence 1:XP_021330047.1 Gene:cacna1aa / 562059 ZFINID:ZDB-GENE-040724-26 Length:2371 Species:Danio rerio
Sequence 2:NP_001259619.1 Gene:para / 32619 FlyBaseID:FBgn0285944 Length:2145 Species:Drosophila melanogaster


Alignment Length:2385 Identity:553/2385 - (23%)
Similarity:917/2385 - (38%) Gaps:750/2385 - (31%)


- Green bases have known domain annotations that are detailed below.


Zfish    65 FTVNRSLFIFSEDNFVRKYAKKITEWPPFEYMILATIIANCIVLALEQHLPDGDKTPMSERLEDT 129
            |:.::::::....|.:|:.|..|...|.|...|:.||:.|||::.:          |.:..:|.|
  Fly   127 FSASKAMWMLDPFNPIRRVAIYILVHPLFSLFIITTILVNCILMIM----------PTTPTVEST 181

Zfish   130 EPYFIGIFCFESGIKILALGFAFHKGSYLRNGWNVMDFVVVLTGILSTVGSDF-DLRTLRAVRVL 193
            |..|.||:.|||.:|::|.||.....:|||:.||.:||||:....: |:|.|. :|..||..|||
  Fly   182 EVIFTGIYTFESAVKVMARGFILCPFTYLRDAWNWLDFVVIALAYV-TMGIDLGNLAALRTFRVL 245

Zfish   194 RPLKLVSGIPSLQVVLKSIMKAMIPLLQIGLLLFFAILMFAIIGLEFYMGKFHTTCFDK------ 252
            |.||.|:.:|.|:.::.::::::..|..:.:|..|::.:||::||:.|||.....|..|      
  Fly   246 RALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYMGVLTQKCIKKFPLDGS 310

Zfish   253 ---ITDEIRE----------------EFP-CGEEVPARICPNGTVC-KKYWLGPNYGITQFDNIL 296
               :|||..:                .|| ||....|..|.:..|| :.:...||||.|.||:..
  Fly   311 WGNLTDENWDYHNRNSSNWYSEDEGISFPLCGNISGAGQCDDDYVCLQGFGPNPNYGYTSFDSFG 375

Zfish   297 FAVLTVFQCITMEGWTDLLYYSNDAAGSAWNWMYFIPLIIIGSFFMLNLVLGVLSGEF------A 355
            :|.|:.|:.:|.:.|.||......||| .|:.::||.:|.:|||:::||:|.:::..:      |
  Fly   376 WAFLSAFRLMTQDFWEDLYQLVLRAAG-PWHMLFFIVIIFLGSFYLVNLILAIVAMSYDELQKKA 439

Zfish   356 KERERVE----NRSEFLKLKRQQQIERELNGYLE----------------------WICKAEEVI 394
            :|.|..|    ..:|.....:..::|...|...:                      :.|.:.|:.
  Fly   440 EEEEAAEEEAIREAEEAAAAKAAKLEERANAQAQAAADAAAAEEAALHPEMAKSPTYSCISYELF 504

Zfish   395 LADEDNDPDDR----------------------------------------------MPFD---- 409
            :..|..:.|:.                                              .||:    
  Fly   505 VGGEKGNDDNNKEKMSIRSVEVESESVSVIQRQPAPTTAHQATKVRKVSTTSLSLPGSPFNIRRG 569

Zfish   410 -------------------GSRRRP----TIKKSKTDLLDAEDGD------------------GD 433
                               ||.|:|    |.:.::..|..|:|.:                  |:
  Fly   570 SRSSHKYTIRNGRGRFGIPGSDRKPLVLSTYQDAQQHLPYADDSNAVTPMSEENGAIIVPVYYGN 634

Zfish   434 IGSPF-------------ARGSL-------------KSSKL------------------------ 448
            :||..             :.|.|             |.|||                        
  Fly   635 LGSRHSSYTSHQSRISYTSHGDLLGGMAVMGVSTMTKESKLRNRNTRNQSVGATNGGTTCLDTNH 699

Zfish   449 ----------------------------------------------------------------- 448
                                                                             
  Fly   700 KLDHRDYEIGLECTDEAGKIKHHDNPFIEPVQTQTVVDMKDVMVLNDIIEQAAGRHSRASDRGVS 764

Zfish   449 -----------EGSSFHKKERRLRFFIRRI------------VKTQAF-----------YWTVLC 479
                       :|.:|  |::.|...::.|            :|.|.:           .:..||
  Fly   765 VYYFPTEDDDEDGPTF--KDKALEVILKGIDVFCVWDCCWVWLKFQEWVSLIVFDPFVELFITLC 827

Zfish   480 LVGLNTLCVAVVHYDQPETLSDFLYFAEFIFLGIFMSEMCIKMYGLGTRPYFHSSFNCFDCIVIC 544
            :| :||:.:|:.|:|..:.:...|....:.|...|..|..:|:..:..:.||...:|.||.|::.
  Fly   828 IV-VNTMFMAMDHHDMNKEMERVLKSGNYFFTATFAIEATMKLMAMSPKYYFQEGWNIFDFIIVA 891

Zfish   545 GSIFEVLWAMIQPGTSFGISVLRALRLLRIFKVTKYWASLRNLVVSLL-NSMKSIISLLFLLFLF 608
            .|:.|:....:|     |:||||:.||||:||:.|.|.:| ||::|:: .:|.::.:|.|:|.:.
  Fly   892 LSLLELGLEGVQ-----GLSVLRSFRLLRVFKLAKSWPTL-NLLISIMGRTMGALGNLTFVLCII 950

Zfish   609 IVVFALLGMQLFGGQFN-----FEAG-TPPTNFDTFPAAIMTVFQILTGEDWNMVMYDGIESQGG 667
            |.:||::||||||..::     |..| .|..||..|..:.|.||::|.|| |...|:|      .
  Fly   951 IFIFAVMGMQLFGKNYHDHKDRFPDGDLPRWNFTDFMHSFMIVFRVLCGE-WIESMWD------C 1008

Zfish   668 VKKGMVFSV-FFIVLTLFGNYTLLNVFLAIAVDNLANAQELTKDEQEEEQAANKKMALQTAKEVA 731
            :..|.|..: ||:...:.||..:||:|||:.:.|..::                           
  Fly  1009 MYVGDVSCIPFFLATVVIGNLVVLNLFLALLLSNFGSS--------------------------- 1046

Zfish   732 EVSPLSAANLSIAAVTVNSERLDATEHFLDCKEQQKNHKGCKSVWEQRTSELRRQTLVNSREALY 796
                      |::|.|.:::.....|.|        |..|....|.:|                 
  Fly  1047 ----------SLSAPTADNDTNKIAEAF--------NRIGRFKSWVKR----------------- 1076

Zfish   797 NELDPEDRWKVSYSRHIRPDMKTHLDRPLVVDPQENRNNNTN-------------KTRPGDGQPQ 848
               :..|.:|:         ::..|...:...|...|.|..:             ....||.:.:
  Fly  1077 ---NIADCFKL---------IRNKLTNQISDQPSGERTNQISWIWSEGKGVCRCISAEHGDNELE 1129

Zfish   849 HSHQ------LLHKQPNFNEAETGGGGGSESWPALE--RGDSTGSRRSLLGSEHYEEGRESHRRH 905
            ..|.      |:.|             |.:....||  .||         |.|....|...:.:.
  Fly  1130 LGHDEILADGLIKK-------------GIKEQTQLEVAIGD---------GMEFTIHGDMKNNKP 1172

Zfish   906 QHSQHCSQARQHRKAAEGGGEPGGRRHRSKAKERGPECEHSDGGERKHRRHRHEGEGRKERGVRH 970
            :.|::.:.|.....|:                       .:..|..|:|..:.|........:..
  Fly  1173 KKSKYLNNATDDDTAS-----------------------INSYGSHKNRPFKDESHKGSAETMEG 1214

Zfish   971 RNRRDGHASGPTLSTTRPIQKTLSRQDSQYSEDLDNAMNNKLATQPHDSLLNLANTAHSAGLAHT 1035
            ..:||.                 |::|....|:||.  ..:....|.|..:          :.|.
  Fly  1215 EEKRDA-----------------SKEDLGLDEELDE--EGECEEGPLDGDI----------IIHA 1250

Zfish  1036 GTESSLILTNPSSTIANVTSIGHLGMKPEYTAVDIPPMFPSSNAILQVNKNANTEPLPKKEDTKG 1100
            ..|..|                     .||.|...|..:.....||                 .|
  Fly  1251 HDEDIL---------------------DEYPADCCPDSYYKKFPIL-----------------AG 1277

Zfish  1101 DDDDDEKDDGGPKPMPPYTSMFILTTTNPF-------RRLCHYIVTLRYFEMCILLVIAMSSIAL 1158
            |||                        :||       |.....::..:|||..::.:|.|||:||
  Fly  1278 DDD------------------------SPFWQGWGNLRLKTFQLIENKYFETAVITMILMSSLAL 1318

Zfish  1159 AAEDPVWPESP-RNNVLRYFDYVFTGVFTFEMLIKMVDLGLVLHQGSYFRDLWNILDFIVVSGAL 1222
            |.||...|:.| ..::|.|.|.:||.:|..|||||.:.||..:    ||.:.|..|||::|..:|
  Fly  1319 ALEDVHLPQRPILQDILYYMDRIFTVIFFLEMLIKWLALGFKV----YFTNAWCWLDFVIVMVSL 1379

Zfish  1223 VAF-AFTGGSGGSSKGKDISTIKSLRVLRVLRPLKTIKRLPKLKAVFDCVVNSLKNVLNILIVYM 1286
            :.| |...|:||      |...|::|.||.||||:.:.|:..::.|.:.:|.::.::.|:|:|.:
  Fly  1380 INFVASLVGAGG------IQAFKTMRTLRALRPLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCL 1438

Zfish  1287 LFMFIFAVVAVQLFKGRFFYCTDESKEFERDCRGEYLVYE---RDNEVRSQKREWKKYDFHYDNV 1348
            :|..|||::.||||.|::|.|        .|..|..|.:|   ..|...|:...|.....::|:|
  Fly  1439 IFWLIFAIMGVQLFAGKYFKC--------EDMNGTKLSHEIIPNRNACESENYTWVNSAMNFDHV 1495

Zfish  1349 LWALLTLFTVSTGEGWPQVLKHSVDATYENQGPSPGYRMEMSIF---YVVYFVVF-PFFFVNIFV 1409
            ..|.|.||.|:|.:||.|::..::|:...::.|.    .|.:|:   |.|:|::| .||.:|:|:
  Fly  1496 GNAYLCLFQVATFKGWIQIMNDAIDSREVDKQPI----RETNIYMYLYFVFFIIFGSFFTLNLFI 1556

Zfish  1410 ALIIITFQEQGDK--------MMEDYSLEKNERACIDFAINAKPLTRHMPQNKQTFQYRMWEFVV 1466
            .:||..|.||..|        |.||   :|.....:....:.||| :.:|:.:...|..::|.|.
  Fly  1557 GVIIDNFNEQKKKAGGSLEMFMTED---QKKYYNAMKKMGSKKPL-KAIPRPRWRPQAIVFEIVT 1617

Zfish  1467 SPPFEYTIMALIALNTIVLMM-KYDGASLTYEDVLKYLNIVFTSLFSMECILKIIAFGALNYFKD 1530
            ...|:..||..|.||...:.: :|| ||.||..||.|||.:|..:||.||:|||.|. ..:||.:
  Fly  1618 DKKFDIIIMLFIGLNMFTMTLDRYD-ASDTYNAVLDYLNAIFVVIFSSECLLKIFAL-RYHYFIE 1680

Zfish  1531 AWNIFDCVTVLGSITDILVTELGMNNFINLSFLRLFRAA---RLIKLLRQGETIRILLWTFVQSF 1592
            .||:||.|.|:.||..::::::....|::.:.||:.|.|   |:::|::..:.||.||:....|.
  Fly  1681 PWNLFDVVVVILSILGLVLSDIIEKYFVSPTLLRVVRVAKVGRVLRLVKGAKGIRTLLFALAMSL 1745

Zfish  1593 KALPYVCLLIAMLFFIYAIIGMQLFGNIKIEENSDSAITQHNNFRTFFQALMLLFRSATGEAWHD 1657
            .||..:|||:.::.||:||.||..|.::|    ..|.|....||:||.|:::|||:.:|...|..
  Fly  1746 PALFNICLLLFLVMFIFAIFGMSFFMHVK----EKSGINDVYNFKTFGQSMILLFQMSTSAGWDG 1806

Zfish  1658 IMLSCLGKKPCDILSDNPK---PECGSEFAYLYF-VSFIFLCSFLMLNLFVAVIMDNFEYLTRD- 1717
            ::.:.:.::.|| ..||.|   ..|||....:.| :|::.:...:::|:::|||::|:...|.| 
  Fly  1807 VLDAIINEEACD-PPDNDKGYPGNCGSATVGITFLLSYLVISFLIVINMYIAVILENYSQATEDV 1870

Zfish  1718 SSILGPHHLDEYVRIWAEYDPAACGRIHYKDMYSLLRVIDPPLGLGKKCPHRVACKRLLRMDLPV 1782
            ...|.....|.|..||.::||.....|.|..:...|.|::|||.:.|  |::.   :::.||:|:
  Fly  1871 QEGLTDDDYDMYYEIWQQFDPEGTQYIRYDQLSEFLDVLEPPLQIHK--PNKY---KIISMDIPI 1930

Zfish  1783 ADDNTVHFNSTLMALIRTALDIKIAKG------GEGGVDKHQMDAELRKEMMA-IWPNLSQKNLD 1840
            ...:.::....|.||.:   |....||      ||.|....:.|.|..:.:.: :|....:    
  Fly  1931 CRGDLMYCVDILDALTK---DFFARKGNPIEETGEIGEIAARPDTEGYEPVSSTLWRQREE---- 1988

Zfish  1841 LLVTPHKSATDLTVGKIYAAMMIMEYYRQSKAKRTQALHDEQNRTPLMFQRLEPPSPSQDVGPGL 1905
                             |.|.:|...:|:.||:.......|               |..|.|.| 
  Fly  1989 -----------------YCARLIQHAWRKHKARGEGGGSFE---------------PDTDHGDG- 2020

Zfish  1906 TGLPDTQMHPANHLPVDERIPESQSWVTARAQEISQKAGNWSPEGQHPDDTTDNRRQSQTVEMRE 1970
             |.||                                ||:     ..||:.||....:       
  Fly  2021 -GDPD--------------------------------AGD-----PAPDEATDGDAPA------- 2040

Zfish  1971 MGRDGYSDTEQYLPMEGHGRAASMPRLPADNQQPRRKGRHRGENLTQPITDNSPMKRSASSLGHG 2035
             |.||        .:.|....|:    .||.......|..............:....:|.|.|.|
  Fly  2041 -GGDG--------SVNGTAEGAA----DADESNVNSPGEDAAAAAAAAAAAAAAGTTTAGSPGAG 2092

Zfish  2036 RAGRSMRGEDYAMERVIPEEGHRHGHRHRDRSHRASERSLSRYTD 2080
            .|||.       ...::..:|....:.|:...|..|....||..|
  Fly  2093 SAGRQ-------TAVLVESDGFVTKNGHKVVIHSRSPSITSRTAD 2130

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
cacna1aaXP_021330047.1 Ion_trans 90..362 CDD:306908 99/305 (32%)
Ion_trans 471..709 CDD:306908 80/256 (31%)
Ion_trans 1141..1377 CDD:306908 85/240 (35%)
Ion_trans 1467..1719 CDD:306908 90/260 (35%)
GPHH 1720..1790 CDD:318993 19/69 (28%)
Ca_chan_IQ 1792..1870 CDD:312334 16/84 (19%)
SOBP <2151..2361 CDD:317654
paraNP_001259619.1 Ion_trans 165..436 CDD:278921 91/282 (32%)
Na_trans_cytopl 515..648 CDD:288761 13/132 (10%)
Ion_trans 835..1028 CDD:278921 66/205 (32%)
Na_trans_assoc 1054..1296 CDD:284034 57/414 (14%)
Ion_trans 1318..1571 CDD:278921 94/274 (34%)
Na_channel_gate 1561..1613 CDD:240441 13/55 (24%)
Ion_trans 1636..1871 CDD:278921 84/241 (35%)
GPHH 1880..1930 CDD:293510 17/54 (31%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
10.910

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