DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment rps6ka4 and S6k

DIOPT Version :9

Sequence 1:	XP_005165672.1	Gene:	rps6ka4 / 561959	ZFINID:	ZDB-GENE-060526-284	Length:	786	Species:	Danio rerio
Sequence 2:	NP_001261450.1	Gene:	S6k / 38654	FlyBaseID:	FBgn0283472	Length:	490	Species:	Drosophila melanogaster

Alignment Length:	467	Identity:	205/467 - (43%)
Similarity:	275/467 - (58%)	Gaps:	41/467 - (8%)

- Green bases have known domain annotations that are detailed below.

Zfish     1 MSGDSSGSSGED----SDRETRRKVCTVKHEITNA---------NLTGYTEKVGMENFELLKVLG 52
            :..|.:..|.:|    .|.:...::|...|:.|..         |:.....|:|.::|||.||||
  Fly    20 LQDDKARDSDDDRIELDDVDLEPELCINLHQDTEGQETIQLCEENVNPGKIKLGPKDFELKKVLG 84

Zfish    53 TGAYGKVFLVRKISGHDKGKLYAMKVLKKAAIVQKAKTAEHTRTERQVLEHIRQSPFLVTLHYAF 117
            .|.|||||.|||.:|.|..|.:||||||||:||...|...|||.||.:||.::. ||:|.|.|||
  Fly    85 KGGYGKVFQVRKTAGRDANKYFAMKVLKKASIVTNQKDTAHTRAERNILEAVKH-PFIVELVYAF 148

Zfish   118 QTQTKLHLILDYVSGGEMFTHLYQRDHFSEDEVRIYVGEIILALEHLHKLGIVYRDIKLENILLD 182
            ||..||:|||:|:||||:|.||.:...|.||....|:.||||||.|||||||:|||:|.||||||
  Fly   149 QTDGKLYLILEYLSGGELFMHLEREGIFLEDTTCFYLSEIILALGHLHKLGIIYRDLKPENILLD 213

Zfish   183 SDGHVVLTDFGLSKEFLEEEKERTYSFCGTIEYMAPEIIRGKSGHGKAVDWWSLGILMFELLTGA 247
            :.|||.||||||.||.::|... |::||||||||||||:. :|||||||||||||.|||::|||.
  Fly   214 AQGHVKLTDFGLCKEHIQEGIV-THTFCGTIEYMAPEILT-RSGHGKAVDWWSLGALMFDMLTGV 276

Zfish   248 SPFTLEGERNSQSEVSKRILRCEPPFPSIIGPLAQDLLRKLIVKDPHKRLGSGPRGAEEIKGHPF 312
            .|||.|    ::.:..:.||:.:...|:.:.|.|:||:|:|:.:...:||||||..|..::.|||
  Fly   277 PPFTAE----NRKKTIETILKAKLNLPAYLTPEARDLVRRLMKRQEPQRLGSGPEDAAAVQIHPF 337

Zfish   313 FKGLNWSDLAEKKVQSPFRPELRDELDVGNFAEEFTGMEPVYSPAST--PPSTDRLFQGYSFVAP 375
            ||.:||.|:..::::.|.:|.||.|.||..|...||...||.||..|  ..|.:.:|||:::|||
  Fly   338 FKHVNWDDVLARRLEPPIKPLLRSEDDVSQFDTRFTRQIPVDSPDDTTLSESANLIFQGFTYVAP 402

Zfish   376 SILFNKNVVMADVLDAHVNVDRPGSATVQRSAMLKESQFFQHY---------ELCLQGSPLGEGS 431
            |||          .|.|.....|..:..:....|.:|.|...:         .|.:.|.....|.
  Fly   403 SIL----------EDMHRANRMPARSPRRTPRQLPDSSFRLQFPSANVGANAPLAMHGHSQRSGM 457

Zfish   432 FSVCRKCRHKQS 443
            |:......|.|:
  Fly   458 FARATPPHHMQT 469

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rps6ka4	XP_005165672.1	STKc_MSK2_N	44..375	CDD:270765	178/332 (54%)
		S_TKc	45..313	CDD:214567	152/267 (57%)
		STKc_MSK2_C	414..724	CDD:271082	7/39 (18%)
		S_TKc	418..684	CDD:214567	6/35 (17%)
S6k	NP_001261450.1	PTZ00263	76..397	CDD:140289	176/327 (54%)
S6k	NP_001261450.1	STKc_p70S6K	81..402	CDD:270736	175/327 (54%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170573235
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1132245at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R469
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.880