DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ptpn2b and Ptp61F

DIOPT Version :9

Sequence 1:	NP_997819.1	Gene:	ptpn2b / 561613	ZFINID:	ZDB-GENE-030909-8	Length:	393	Species:	Danio rerio
Sequence 2:	NP_476687.1	Gene:	Ptp61F / 38160	FlyBaseID:	FBgn0267487	Length:	548	Species:	Drosophila melanogaster

Alignment Length:	362	Identity:	156/362 - (43%)
Similarity:	223/362 - (61%)	Gaps:	22/362 - (6%)

- Green bases have known domain annotations that are detailed below.

Zfish     1 MEQEFEDIDSEG-RWQNIYLEI----RNQSHECAFKVAKYPE--NRIRNRYRDVSPFDHSRVKLE 58
            :|.|::|   :| :|...|.||    ..::.|..|..::...  ||..||||||:|:||||:.|:
  Fly    19 IEAEYKD---KGPQWHRFYKEICETCDREAKEKQFSTSESERHTNRGLNRYRDVNPYDHSRIVLK 80

Zfish    59 NTENDYINASLVVMEEAQRRYILTQGPLRNTCGHFWLMIWEQKTKAVIMLNRVIEKGSEKCAQYW 123
            ....|||||:||.:|.|:|:||||||||.:|.||||||:||||::||:|||:::||...||..||
  Fly    81 RGSVDYINANLVQLERAERQYILTQGPLVDTVGHFWLMVWEQKSRAVLMLNKLMEKKQIKCHLYW 145

Zfish   124 PTQ--EEREMSFRDTRFVVTLVSEDVKSYYTTRVLELQNANTGETREIYHFHYTTWPDFGVPESP 186
            |.:  .::.:.....:..|.||..:....:..|..:|.:..|.::||:..||||||||||:|.||
  Fly   146 PNEMGADKALKLPHVKLTVELVRLETYQNFVRRWFKLTDLETQQSREVMQFHYTTWPDFGIPSSP 210

Zfish   187 ASFLNFLFKVRESGSLGMEQGPAVVHCSAGIGRSGTFSLVDTCLVLMDKRKDPLLVDIKKILLDM 251
            .:||.||.:||:||.|..:.|||||||||||||||||.|||.||||:||..:   .::.|:|.::
  Fly   211 NAFLKFLQQVRDSGCLSRDVGPAVVHCSAGIGRSGTFCLVDCCLVLIDKYGE---CNVSKVLCEL 272

Zfish   252 RKYRMGLIQTPDQLRFSYMAVLEGAKYIMGDSSVQKQWRELSREDQEPLSESPPPPQPPKCTERY 316
            |.||||||||.|||.|||.|::||.|.:...:.:..:...:|.:.:....:..|||.||:....
  Fly   273 RSYRMGLIQTADQLDFSYQAIIEGIKKLHDPTFLDAEEPLISNDTETHTLDELPPPLPPRVQSL- 336

Zfish   317 NGSKPAHLEDG----IDSKTGKKTGPEAPNKEPDRDA 349
              :.|.....|    ::.:..:..|.|:..||..:||
  Fly   337 --NLPLAPNSGGILSLNMRAAQANGAESIGKELSKDA 371

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ptpn2b	NP_997819.1	PTPc	1..274	CDD:214550	139/281 (49%)
ptpn2b	NP_997819.1	PTPc	41..274	CDD:238006	127/234 (54%)
Ptp61F	NP_476687.1	PTPc	34..295	CDD:214550	134/263 (51%)
Ptp61F	NP_476687.1	PTPc	62..295	CDD:238006	127/235 (54%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170596321
Domainoid	1	1.000	269	1.000	Domainoid score	I1802
eggNOG	1	0.900	-	-		E2759_KOG0789
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H7497
Inparanoid	1	1.050	289	1.000	Inparanoid score	I2798
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D305231at33208
OrthoFinder	1	1.000	-	-		FOG0000704
OrthoInspector	1	1.000	-	-		otm25111
orthoMCL	1	0.900	-	-		OOG6_104767
Panther	1	1.100	-	-	O	PTHR46047
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4733
SonicParanoid	1	1.000	-	-		X2326
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	15	14.830