DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PRKX and for

DIOPT Version :9

Sequence 1:	NP_005035.1	Gene:	PRKX / 5613	HGNCID:	9441	Length:	358	Species:	Homo sapiens
Sequence 2:	NP_477487.1	Gene:	for / 44817	FlyBaseID:	FBgn0000721	Length:	1088	Species:	Drosophila melanogaster

Alignment Length:	339	Identity:	142/339 - (41%)
Similarity:	209/339 - (61%)	Gaps:	26/339 - (7%)

- Green bases have known domain annotations that are detailed below.

Human    15 DSRKVAEETPDGAPALCPSPEALSPEPPVYSLQDFDTLATVGTGTFGRVHLVKEK-TAKHFFALK 78
            :.||:.||..|                  .:|.|...:||:|.|.||||.||:.. .:...||||
  Fly   761 ERRKINEEFRD------------------INLTDLRVIATLGVGGFGRVELVQTNGDSSRSFALK 807

Human    79 VMSIPDVIRLKQEQHVHNEKSVLKEVSHPFLIRLFWTWHDERFLYMLMEYVPGGELFSYLRNRGR 143
            .|....::..:|:||:.:||.::.|.:..|:::||.|:.|:::||||||...||||::.||::|.
  Fly   808 QMKKSQIVETRQQQHIMSEKEIMGEANCQFIVKLFKTFKDKKYLYMLMESCLGGELWTILRDKGN 872

Human   144 FSSTTGLFYSAEIICAIEYLHSKEIVYRDLKPENILLDRDGHIKLTDFGFAKKLVD--RTWTLCG 206
            |..:|..||:|.::.|.:||||:.|:||||||||:||:..|::||.||||||||..  :|||.||
  Fly   873 FDDSTTRFYTACVVEAFDYLHSRNIIYRDLKPENLLLNERGYVKLVDFGFAKKLQTGRKTWTFCG 937

Human   207 TPEYLAPEVIQSKGHGRAVDWWALGILIFEMLSGFPPFFDDNPFGIYQKILAG--KIDFPRHLDF 269
            ||||:|||||.::||..:.|:|:||:|:||:|:|.|||...:|...|..||.|  .|:|||::..
  Fly   938 TPEYVAPEVILNRGHDISADYWSLGVLMFELLTGTPPFTGSDPMRTYNIILKGIDAIEFPRNITR 1002

Human   270 HVKDLIKKLLVVDRTRRLGNMKNGANDVKHHRWFRSVDWEAVPQRKLKPPIVPKIAGDGDTSNFE 334
            :..:|||||...:...|||..:.|.::::.|:||....|..:....|:|||.|.:....||:||:
  Fly  1003 NASNLIKKLCRDNPAERLGYQRGGISEIQKHKWFDGFYWWGLQNCTLEPPIKPAVKSVVDTTNFD 1067

Human   335 TYPENDWDTAAPVP 348
            .||.   |...|.|
  Fly  1068 DYPP---DPEGPPP 1078

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PRKX	NP_005035.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..34		5/18 (28%)
		PTZ00263	39..358	CDD:140289	137/315 (43%)
		STKc_PRKX_like	47..338	CDD:270763	132/295 (45%)
for	NP_477487.1	DD_cGKI-alpha	385..432	CDD:213374
		Crp	518..>627	CDD:223736
		CAP_ED	520..629	CDD:237999
		Crp	632..>753	CDD:223736
		CAP_ED	638..754	CDD:237999
		S_TKc	778..1036	CDD:214567	118/257 (46%)
		STKc_cGK	783..1043	CDD:270724	119/259 (46%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0616
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810