DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PRKX and Pka-C1

DIOPT Version :9

Sequence 1:	NP_005035.1	Gene:	PRKX / 5613	HGNCID:	9441	Length:	358	Species:	Homo sapiens
Sequence 2:	NP_476977.1	Gene:	Pka-C1 / 34284	FlyBaseID:	FBgn0000273	Length:	353	Species:	Drosophila melanogaster

Alignment Length:	294	Identity:	157/294 - (53%)
Similarity:	222/294 - (75%)	Gaps:	0/294 - (0%)

- Green bases have known domain annotations that are detailed below.

Human    45 SLQDFDTLATVGTGTFGRVHLVKEKTAKHFFALKVMSIPDVIRLKQEQHVHNEKSVLKEVSHPFL 109
            :|.||:.:.|:|||:||||.:|:.|..|.::|:|::....|::|||.:|..|||.:|:.:..|||
  Fly    42 ALDDFERIKTLGTGSFGRVMIVQHKPTKDYYAMKILDKQKVVKLKQVEHTLNEKRILQAIQFPFL 106

Human   110 IRLFWTWHDERFLYMLMEYVPGGELFSYLRNRGRFSSTTGLFYSAEIICAIEYLHSKEIVYRDLK 174
            :.|.:.:.|...|||::|||||||:||:||..||||.....||:|:|:.|.||||..:::|||||
  Fly   107 VSLRYHFKDNSNLYMVLEYVPGGEMFSHLRKVGRFSEPHSRFYAAQIVLAFEYLHYLDLIYRDLK 171

Human   175 PENILLDRDGHIKLTDFGFAKKLVDRTWTLCGTPEYLAPEVIQSKGHGRAVDWWALGILIFEMLS 239
            |||:|:|..|::|:|||||||::..|||||||||||||||:|.|||:.:||||||||:|::||.:
  Fly   172 PENLLIDSQGYLKVTDFGFAKRVKGRTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLVYEMAA 236

Human   240 GFPPFFDDNPFGIYQKILAGKIDFPRHLDFHVKDLIKKLLVVDRTRRLGNMKNGANDVKHHRWFR 304
            |:||||.|.|..||:||::||:.||.|....:|||::.||.||.|:|.||:|.|.||:|:.:||.
  Fly   237 GYPPFFADQPIQIYEKIVSGKVRFPSHFGSDLKDLLRNLLQVDLTKRYGNLKAGVNDIKNQKWFA 301

Human   305 SVDWEAVPQRKLKPPIVPKIAGDGDTSNFETYPE 338
            |.||.|:.|:|::.|.:|:..|.||||||:.|.|
  Fly   302 STDWIAIFQKKIEAPFIPRCKGPGDTSNFDDYEE 335

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PRKX	NP_005035.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..34
		PTZ00263	39..358	CDD:140289	157/294 (53%)
		STKc_PRKX_like	47..338	CDD:270763	155/290 (53%)
Pka-C1	NP_476977.1	STKc_PKA	44..333	CDD:271111	154/288 (53%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0616
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D277423at33208
OrthoFinder	1	1.000	-	-		FOG0000539
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100326
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.720