DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment si:ch73-206d17.1 and btl

DIOPT Version :9

Sequence 1:	XP_689652.2	Gene:	si:ch73-206d17.1 / 561155	ZFINID:	ZDB-GENE-090313-143	Length:	393	Species:	Danio rerio
Sequence 2:	NP_001014583.1	Gene:	btl / 39564	FlyBaseID:	FBgn0285896	Length:	1052	Species:	Drosophila melanogaster

Alignment Length:	459	Identity:	110/459 - (23%)
Similarity:	200/459 - (43%)	Gaps:	91/459 - (19%)

- Green bases have known domain annotations that are detailed below.

Zfish     7 CNISSG---SDPACYDEGSGPLAVIIIPSLL-------ALSTLIVVSQIIW-----SFVTKRSSA 56
            |..|||   |:.:.|.....||..:.|.:||       .|:.:.:|:..:.     :|:.:|...
  Fly   566 CLASSGLGRSNSSVYLRVVSPLPPLEIYALLHAHPLGFTLAAITIVALFLLGSAFITFMLRRLRR 630

Zfish    57 QKITS--------------------------SSSNVN------EREHVQLD-AGIGSLRPANVLG 88
            :|:..                          ||.::.      |::...:. .|.|...||....
  Fly   631 EKLLKLRIETVHQWTKKVIIYRPGGEEGSGCSSGDLQMPVIRIEKQRTTVSTTGTGGTDPAQGFN 695

Zfish    89 PLELPVQCTLE--------GVEVLQMGRYGPICMGQLK-----QDNTSTAVMIKTLKDRSTQSES 140
            ..|.|:....|        | .:|..|.:|.:.|.:.:     .....|.|.:|.:|:..|.::.
  Fly   696 EYEFPLDSNWEIPRQQLSLG-SILGEGAFGRVVMAEAEGLPRSPQLAETIVAVKMVKEEHTDTDM 759

Zfish   141 AEFMDLVLFHAAVSKHENIVKLLFCQTRRTPMYLLLEASVPGNLLNFLWSLREDRCG-------- 197
            |..:..:.....:.||.||:.||.|.::..|:::::|.:..|||.:|   |:::|.|
  Fly   760 ASLVREMEVMKMIGKHINIINLLGCCSQGGPLWVIVEYAPHGNLKDF---LKQNRPGAPQRRSDS 821

Zfish   198 ----------ESSVFSEKSVFLVAKQIAAGLDYLHSHHRVIHGDVAARNMLIGSAFSVKVSGLDF 252
                      .:....||.:...|.|||.|::||.| .|.||.|:||||:|:...:.:|::....
  Fly   822 DGYLDDKPLISTQHLGEKELTKFAFQIARGMEYLAS-RRCIHRDLAARNVLVSDGYVMKIADFGL 885

Zfish   253 AFESRQKKKVDREQEANVPVKWQAPERMMRLPLTDRSDVWSFGILLYEMITLGSPPYPD-LDPSE 316
            |.:.:..:...:.....:|:||.|||.:.......:|||||:|:||:|::|.|..|||. |...|
  Fly   886 ARDIQDTEYYRKNTNGRLPIKWMAPESLQEKKYDSQSDVWSYGVLLWEIMTYGDQPYPHILSAEE 950

Zfish   317 VLPRTLAHYRMKRPENCGAPLFDLIKYCCMWNFKD--RPVYSAIIRLLDSYSYFADTKPLCSEVQ 379
            :....:...||::|..|...::.:::.|  |:|:.  ||.::.::...|.....|.:.|  ::..
  Fly   951 LYSYLITGQRMEKPAKCSLNIYVVMRQC--WHFESCARPTFAELVESFDGILQQASSNP--NDAY 1011

Zfish   380 IDVS 383
            :|:|
  Fly  1012 LDLS 1015

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
si:ch73-206d17.1	XP_689652.2	PKc_like	102..363	CDD:304357	78/286 (27%)
si:ch73-206d17.1	XP_689652.2	Pkinase_Tyr	102..362	CDD:285015	78/285 (27%)
btl	NP_001014583.1	IG_like	149..232	CDD:214653
		IGc2	157..215	CDD:197706
		IG	247..336	CDD:214652
		Ig	258..340	CDD:143165
		I-set	394..479	CDD:254352
		IGc2	408..469	CDD:197706
		IG_like	492..583	CDD:214653	6/16 (38%)
		Ig	507..583	CDD:299845	6/16 (38%)
		PKc_like	700..1000	CDD:304357	82/306 (27%)
		TyrKc	712..996	CDD:197581	79/290 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0200
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810