DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PCDHGB3 and cdh-8

DIOPT Version :9

Sequence 1:	NP_061747.2	Gene:	PCDHGB3 / 56102	HGNCID:	8710	Length:	929	Species:	Homo sapiens
Sequence 2:	NP_001294412.1	Gene:	cdh-8 / 184652	WormBaseID:	WBGene00017576	Length:	1684	Species:	Caenorhabditis elegans

Alignment Length:	836	Identity:	194/836 - (23%)
Similarity:	327/836 - (39%)	Gaps:	246/836 - (29%)

- Green bases have known domain annotations that are detailed below.

Human    18 FLFLLSLLD-----QALSEPIRYAIPEELDRGSLVGNLAKDLGFGVGDLPT----RNLRVIA--E 71
            ||.||..|.     |.|.||....:.|:...|:              .||.    :|:::::  .
Worm    10 FLILLGCLKGTDSAQLLIEPSFLLVEEDWPVGT--------------HLPVTICPKNVKILSGDP 60

Human    72 KKFFTVSPENG-------NL-LVSDRIDREEICG----------KKSTCVLEFEMVAEKPLNFFH 118
            ..:|||...|.       || |.:|:.:.:.:.|          |||...||.::|
Worm    61 ASYFTVVKINETCSTLQLNLALDADKENADGLRGQSFSLVIAGPKKSRATLEVQIV--------- 116

Human   119 VTVLIQDINDNPPTFSQNITELEISELALTGATFALESAQDPDVGVNSLQQYYLSPDPHFSLIQK 183
                  |:|||.|.||...:..||||.|..|......:..|||.|::.:.::.:..|..|:|.::
Worm   117 ------DVNDNSPQFSNTPSSFEISENAEIGTDIFKVTTLDPDTGISGISRFSVEGDSSFTLAKR 175

Human   184 ENLDGSRYPELVLKAPLDREEQPHHHLVLTAVDGGEPSRSCTT---QIRVIVADANDNPPVFTQD 245
            :...|....:|.|...||.||:|.|...:||.||...|....|   .:.:.|.:.||.||.|..|
Worm   176 KCSSGKCSTQLRLAKKLDFEEKPIHTFNITAKDGDPHSNRTHTVAHTVTIHVKNENDEPPKFLTD 240

Human   246 MYRV-NVAENLPAGSSVLKVMAIDMDEGINAEIIYAFINIGKEVRQLFKLDSKTGELTTIGELDF 309
            ..:| .:.::...|..:.|:.|||::.|       |.|..|.:..:..|:|||:|.:.    |..
Worm   241 FSQVFPIFKSTKPGDIIAKLEAIDVENG-------AEIQFGMKENEHLKIDSKSGNVL----LKK 294

Human   310 EERDSYTIGVE-----AKDGGHHTAYCKVQIDISD--------ENDNAPEI-------------- 347
            ...|...|.||     :|:|...|...|::: ::|        ||...||:
Worm   295 LPTDDALITVELYATSSKNGKSKTVEMKLRL-MNDEATLPKIAENQEKPELCEFPIYEAHLIQGT 358

Human   348 ----------TLASESQ--------------------HIQ---EDAE------LGTAVALIKTHD 373
                      ||.|.::                    |::   .:||      |.:|..|:|:.
Worm   359 GTFSTPLKIKTLKSMAEEKPRLIGGSESFDLNVIDDFHVELKVLNAEKVASQVLDSAQLLVKSQ- 422

Human   374 LDSGFNGEILCQL--------------------------KGNFPFKIVQDTKNT----YRLVTDG 408
                 :|:  |::                          |..:.|::|::.:.|    .::::||
Worm   423 -----SGQ--CRIVLRSAAQMTPKASPIAQKLKIIPKFEKSEYQFQVVENREPTVLGEVKVISDG 480

Human   409 --------------------------ALDREQIPEYNVTITATDKGNPPLSSSKT-ITLHILDVN 446
                                      .:|||...::.:.:.|||...   ||.|: :.:|:.|.|
Worm   481 PVTYEILGENGEKFQISNDGEIQNLEPIDRETYEKFELIVKATDLNG---SSGKSQLIIHVKDEN 542

Human   447 DNVPVFHQASYTVHVAENNPPGASIAHVRASDPDLGPNGLVSYYI------VASDLEPRELSSYV 505
            ||.|:|.:..|.:.|.|.......|.   |:|.|.|.||.:.|.|      :..|:.|
Worm   543 DNSPIFDKEHYFITVDEGKSEKLKIT---ATDADSGKNGQIVYSIDQKIDNLPIDISP------- 597

Human   506 SVSARSGVVFAQRAFDHEQL---RAFELTLQARDQGSPTLSANVSLRVLVDDRNDNAPLVLYPAL 567
                 .|::|. .|.|.|.:   ....||:.|.|.|.|..||:.::.:.|.|.|||:|:.
Worm   598 -----DGMLFI-GAIDRENMGNSNEVNLTVTASDSGEPKRSASATVTIRVKDINDNSPVF----- 651

Human   568 GPEGSALFDMVPRSAEPGYLVTKVVAVDADS-GYNAWLSYHIVQASEPGLFSLGLRTGEVRTART 631
              ..|.....:..:..||.::.::.|.|||| ..|.:::|   .:.:| .|::. .:||:.....
Worm   652 --SNSRYSIPLDANISPGGIIGRLEATDADSTSPNNYVTY---TSGDP-KFTVS-DSGEILFTGP 709

Human   632 LGDREAARQRLLVTVRDGGQQPLSATVMLHLIFADSLQEIQPDLSDRPTPSDPQAE 687
            ....::|.....||.:|||....||..::.:....|::.|:.:|:.:...:|...|
Worm   710 GTLEKSASLEFNVTAQDGGDPMNSANALVVINEHRSMKSIENELTTQINSNDTGGE 765

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PCDHGB3	NP_061747.2	Cadherin_2	32..112	CDD:311943	21/103 (20%)
		Cadherin_repeat	139..238	CDD:206637	30/101 (30%)
		Cadherin_repeat	247..343	CDD:206637	27/109 (25%)
		Cadherin_repeat	355..448	CDD:206637	27/158 (17%)
		Cadherin_repeat	456..558	CDD:206637	30/110 (27%)
		Cadherin_repeat	578..662	CDD:206637	21/84 (25%)
		Cadherin_C_2	687..769	CDD:318652	1/1 (100%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	791..838
		Cadherin_tail	808..>902	CDD:318236
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	899..929
cdh-8	NP_001294412.1	Cadherin_repeat	<55..121	CDD:206637	17/80 (21%)
		Cadherin_repeat	131..232	CDD:206637	29/100 (29%)
		Cadherin_repeat	457..544	CDD:206637	17/89 (19%)
		Cadherin_repeat	552..647	CDD:206637	30/110 (27%)
		Cadherin_repeat	656..741	CDD:206637	21/89 (24%)
		Cadherin_repeat	861..952	CDD:206637
		Cadherin_repeat	964..1060	CDD:206637
		Cadherin_repeat	1184..1265	CDD:206637
		Cadherin_repeat	1275..1375	CDD:206637
		Cadherin_repeat	1396..1476	CDD:206637
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	48	1.000	Domainoid score	I8810
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	2.000