DRSC/TRiP Functional Genomics Resources

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Protein Alignment EIF2AK2 and niki

DIOPT Version :10

Sequence 1:NP_002750.1 Gene:EIF2AK2 / 5610 HGNCID:9437 Length:551 Species:Homo sapiens
Sequence 2:NP_651293.1 Gene:niki / 42959 FlyBaseID:FBgn0045980 Length:841 Species:Drosophila melanogaster


Alignment Length:365 Identity:98/365 - (26%)
Similarity:164/365 - (44%) Gaps:77/365 - (21%)


- Green bases have known domain annotations that are detailed below.


Human   217 SNSDSLNSSSLLMNGLRNNQRK---------------------AKRSLA-----PRFDLPDMKET 255
            :::.:|.:|||.:...:|.|||                     |..|||     .:..:|:.:|:
  Fly    19 TDATTLTTSSLQLPLGQNTQRKQSTCTRVLPTVFTITDGTTGAASTSLAEAMSSSKAQMPNRQES 83

Human   256 --KYTVDKRFGM--------DFKEIELIGSGGFGQVFKAKHRIDGKTYVIKRVKYN------NEK 304
              :.:|.:..|:        :::::.::|.|.||.....:.:.||...|.|::..:      .:.
  Fly    84 LLQLSVPRETGVGVAGPELANYEKVRVVGQGSFGIAILYRRKSDGHQIVFKQINLSELSPPGRDL 148

Human   305 AEREVKALAKLDHVNIVHYNGCWDGFDYDPETSDDSLESSDYDPENSKNSSRSKTKCLFIQMEFC 369
            |..||...:||.|.|||.|.|                             |..|...|.|:||:.
  Fly   149 AMNEVDVFSKLHHPNIVSYLG-----------------------------SFIKDNTLLIEMEYA 184

Human   370 DKGTLEQWIEKRRGE-KLDKVLALELFEQITKGVDYIHSKKLIHRDLKPSNIFLVDTKQVKIGDF 433
            |.|||.|.|.:|:|: ...:...:.:||||:..::|:||:.::|||||.:|:||.....||||||
  Fly   185 DGGTLAQIIAERQGKLHFPERYIIAVFEQISSAINYMHSENILHRDLKTANVFLNRRGIVKIGDF 249

Human   434 GLVTSLKNDGKRTRSKGTLRYMSPEQISSQDYGKEVDLYALGLILAELLHVCDT--AFETSKFFT 496
            |:...:..........||..|.|||....::|..:.|::|||.||.|:..:..|  |...|:..|
  Fly   250 GISKIMNTKIHAQTVLGTPYYFSPEMCEGKEYDNKSDIWALGCILGEMCCLKKTFAASNLSELVT 314

Human   497 DLRDGIISDI---FDKKEKTLLQKLLSKKPEDRPNTSEIL 533
            .:..|..:.:   :....::|:..||..:...||..||:|
  Fly   315 KIMAGNYTPVPSGYTSGLRSLMSNLLQVEAPRRPTASEVL 354

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
EIF2AK2NP_002750.1 (Microbial infection) Interaction with HCV NS5A. /evidence=ECO:0000269|PubMed:17267064 2..180
DSRM_EIF2AK2_rpt1 8..>59 CDD:380732
DSRM_EIF2AK2_rpt2 99..166 CDD:380733
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 202..222 0/4 (0%)
STKc_EIF2AK2_PKR 260..536 CDD:270949 83/294 (28%)
Interaction with TRAF5. /evidence=ECO:0000269|PubMed:15121867 266..551 82/280 (29%)
Dimerization. /evidence=ECO:0000269|PubMed:16179258 266..362 21/101 (21%)
2 X 13 AA approximate repeats 331..357 1/25 (4%)
Interaction with EIF2S1/EIF-2ALPHA. /evidence=ECO:0000269|PubMed:16179258 379..496 41/119 (34%)
nikiNP_651293.1 STKc_Nek 104..359 CDD:270855 82/280 (29%)
ATS1 433..749 CDD:444065
Blue background indicates that the domain is not in the aligned region.

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