DRSC/TRiP Functional Genomics Resources

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Protein Alignment EIF2AK2 and Wee1

DIOPT Version :10

Sequence 1:NP_002750.1 Gene:EIF2AK2 / 5610 HGNCID:9437 Length:551 Species:Homo sapiens
Sequence 2:NP_477035.1 Gene:Wee1 / 33965 FlyBaseID:FBgn0011737 Length:609 Species:Drosophila melanogaster


Alignment Length:547 Identity:135/547 - (24%)
Similarity:212/547 - (38%) Gaps:170/547 - (31%)


- Green bases have known domain annotations that are detailed below.


Human   108 IAQKKRLTVNYEQCASGVHGPEGFHYKCKMGQKEYSIGTGSTKQEAKQLAAKLAYLQ-ILSEETS 171
            :.|:.:|:...||......|.||       |..:.|:.....|..|.:|.:..|..: ||.:.|:
  Fly    57 LQQRPKLSSGEEQQLDSKIGKEG-------GDGDVSMSPPCQKVRALRLFSTPATPKTILQKSTT 114

Human   172 VKSDYLSSGSFATTCESQSNSLVTSTLASES---SSEGDFSADTSEINS-NSDSL---------- 222
            ..|::||:.:.|.....:|:.|...:....|   .:....:.||:.:|. ..|||          
  Fly   115 QCSNHLSAAAAAVNASRRSDDLFRLSERPRSLPLHNRKLPTQDTANVNPFTPDSLMAHNKKRCRT 179

Human   223 ----NSSSLLMNGLR-----------------NNQRKAKRSLAPRFDLPDMKETKYTVDKRFGMD 266
                .:.:|.:|.::                 ::.|:..:....|..|.|      |...||..:
  Fly   180 QFGRENLNLNVNAMQKYLLSDACDDDVTEEAGDSMREIHQQAPKRLALHD------TNISRFKRE 238

Human   267 FKEIELIGSGGFGQVFKAKHRIDGKTYVIKRVKYN------NEKAEREVKALAKL-DHVNIVHYN 324
            |.::.:||.|.||.||:..:|:||..|.||:.|..      .::|..||.|.|.| .|.|:|.|.
  Fly   239 FMQVNVIGVGEFGVVFQCVNRLDGCIYAIKKSKKPVAGSSFEKRALNEVWAHAVLGKHDNVVRYY 303

Human   325 GCWDGFDYDPETSDDSLESSDYDPENSKNSSRSKTKCLFIQMEFCDKGTLEQWIEKR-RGEKLDK 388
            ..|        ..||.                     :.||.||||.|:|...|:.. .||...|
  Fly   304 SAW--------AEDDH---------------------MLIQNEFCDGGSLHARIQDHCLGEAELK 339

Human   389 VLALELFEQITKGVDYIHSKKLIHRDLKPSNIF---------LVD-----TKQ------------ 427
            ::.:.:.|    |:.||||..|:|.||||.|||         ||:     ||.            
  Fly   340 IVLMHVIE----GLRYIHSNDLVHMDLKPENIFSTMNPNAHKLVEVQPQQTKDDDGMDSVYEELR 400

Human   428 -------VKIGDFGLVTSLKNDGKRTRSKGTLRYMSPEQISSQDYGK--EVDLYALGLILAELLH 483
                   .||||.|.|||:|   :....:|..||: |::|..:||..  :.|:::||:       
  Fly   401 HSENLVTYKIGDLGHVTSVK---EPYVEEGDCRYL-PKEILHEDYSNLFKADIFSLGI------- 454

Human   484 VCDTAFETS---------KFFTDLRDGIISDI--FDKKEKTLLQKLLSKKPEDRPNTSEILR--- 534
               |.||.:         ..:.:||||.:..:  ..:....|:.:::...|:.||.:..|..   
  Fly   455 ---TLFEAAGGGPLPKNGPEWHNLRDGKVPILPSLSRDFNELIAQMMHPYPDKRPTSQSIFSHPI 516

Human   535 --------------TLTVWKKSPEKNE 547
                          .|||.|:   |||
  Fly   517 LSAVDSKSKLQLGLELTVEKR---KNE 540

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
EIF2AK2NP_002750.1 (Microbial infection) Interaction with HCV NS5A. /evidence=ECO:0000269|PubMed:17267064 2..180 19/72 (26%)
DSRM_EIF2AK2_rpt1 8..>59 CDD:380732
DSRM_EIF2AK2_rpt2 99..166 CDD:380733 13/58 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 202..222 5/23 (22%)
STKc_EIF2AK2_PKR 260..536 CDD:270949 92/346 (27%)
Interaction with TRAF5. /evidence=ECO:0000269|PubMed:15121867 266..551 97/353 (27%)
Dimerization. /evidence=ECO:0000269|PubMed:16179258 266..362 28/102 (27%)
2 X 13 AA approximate repeats 331..357 2/25 (8%)
Interaction with EIF2S1/EIF-2ALPHA. /evidence=ECO:0000269|PubMed:16179258 379..496 44/161 (27%)
Wee1NP_477035.1 PTKc_Wee1 238..516 CDD:270953 90/324 (28%)
Blue background indicates that the domain is not in the aligned region.

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