DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment EIF2AK2 and hri1

DIOPT Version :9

Sequence 1:	NP_001129123.1	Gene:	EIF2AK2 / 5610	HGNCID:	9437	Length:	551	Species:	Homo sapiens
Sequence 2:	NP_594738.1	Gene:	hri1 / 2541728	PomBaseID:	SPAC20G4.03c	Length:	704	Species:	Schizosaccharomyces pombe

Alignment Length:	708	Identity:	157/708 - (22%)
Similarity:	249/708 - (35%)	Gaps:	278/708 - (39%)

- Green bases have known domain annotations that are detailed below.

Human    18 RQKQGVVLKYQELPNSGPPHDRRFTFQVIIDGREFPEGEGRSKKEAKNAAAKLAVEILNKEKKAV 82
            :.||..:.....|.|||           ||| .||.|    ..:..:||.|.....:|:|..::.
pombe    67 QSKQMFLYVAHSLQNSG-----------IID-FEFSE----ELEPIRNAYADSLHNLLSKAFRST 115

Human    83 SPLLLTTTNSSEGLSMGNYIGLINRIAQKKRLTVNYEQCASGVHGPEGFHYKCKMGQKEYSIGTG 147
            .|  :::|..|:.....:..|::.:.|.                      :...:....|.....
pombe   116 LP--MSSTKDSKKSRYSSPDGVLAKTAS----------------------FLSVLSDGGYEDDVM 156

Human   148 STKQEAKQLAAKLAYLQILSEETSVKSDYLSSGSFATTCESQSNSLVTSTLASESSSEGDFSADT 212
            :.|.....|:.:|.:|.:.:.|:......|.|.:||..||.:..:             |:.|.
pombe   157 NVKPSVNVLSNRLNHLPVEALESCFPQTTLESSTFADFCEHKDGT-------------GNLSF-- 206

Human   213 SEINSNSDSLNSSSLLMNGLRNNQRKAKRSLAPRFDLPDMKETKYTVDKRFGMDFKEIELIGSGG 277
                ||.||                           .|.::.::|      ..||:|:||:|.||
pombe   207 ----SNFDS---------------------------FPTVQRSRY------ASDFEELELLGKGG 234

Human   278 FGQVFKAKHRIDGKTYVIKRVKY------NNEKAEREVKALAKLDHVNIVHYNGCW--------- 327
            :|.|:||:::.||..|.:|::..      .:....||.:.||:|:|.|::.:...|
pombe   235 YGSVYKARNKFDGVEYALKKIPLRLRSFSTSSNIFRESRTLARLNHPNVIRFFSSWVELLPSSEK 299

Human   328 --------------------DGFDYDPET--------------------SDD-----SLESS--- 344
                                |.|.:|.:|                    :||     |.::|
pombe   300 QIEEEPLASADETLSQSADIDNFMFDMDTGLLQHTYPSSVQILFQEDSVADDLTPCYSTKNSTCN 364

Human   345 -----------DYDPENSKNSSRSK---------TK----------------------------- 360
                       ||...:..:|:.|:         ||
pombe   365 LTDLFKKEADQDYAESHDCSSTTSQVDTLGKLAPTKSASEMLLMDSFLSEREEDECSNIPSFDQQ 429

Human   361 --CLFIQMEFCDKGTLEQWIEKRRGEKLDKVLA-------LELFEQITKGVDYIH-SKKLIHRDL 415
              ||:|||..|:: |||:.| .||.:.:..|::       :.||.:|.:||.|:| :..|:||||
pombe   430 PLCLYIQMALCEE-TLEKHI-NRRNKHIHGVMSKGLRNCYILLFARILEGVLYLHDAMHLVHRDL 492

Human   416 KPSNIFL------------------VDTKQV----------------KIGDFGLVTSLK------ 440
            ||.||||                  .|..:|                ||||||||.|..
pombe   493 KPRNIFLSSGVHSEPCSVCLPNFSDEDNVEVSNAYEPVNQRTLCVVPKIGDFGLVLSQSDNLEEG 557

Human   441 -NDGKRTRSKGTLRYMSPEQISS-----QDYGKEVDLYALGLILAELLHVCDTAFETSKFFTDLR 499
             |....:...||..|.:||..|.     .:.....|:||||::..|||:..:|..|.:....:|:
pombe   558 TNSSAESSFVGTSTYAAPELFSKHMRSVMNNNSSTDIYALGILFFELLYPFNTRMERASAIANLK 622

Human   500 DGII-SDIFDK--KEKTLLQKLLSKKPEDRPN-----TSEILRTLTVWKKSPEKNERH 549
            .||. .|..|.  :|.:|::.:||.. ..||.     ||.:...|.|       ||.|
pombe   623 KGIFPHDFLDSMPEEASLIRSMLSSS-NKRPTAAQLLTSNLFHDLVV-------NELH 672

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
EIF2AK2	NP_001129123.1	(Microbial infection) Interaction with HCV NS5A. /evidence=ECO:0000269\|PubMed:17267064	2..180		29/161 (18%)
		DSRM	14..>59	CDD:214634	12/40 (30%)
		DSRM	101..166	CDD:214634	7/64 (11%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	202..222		5/19 (26%)
		STKc_EIF2AK2_PKR	260..536	CDD:270949	110/451 (24%)
		Interaction with TRAF5. /evidence=ECO:0000269\|PubMed:15121867	266..551		115/460 (25%)
		2 X 13 AA approximate repeats	331..357		9/64 (14%)
hri1	NP_594738.1	STKc_EIF2AK	217..661	CDD:270898	110/452 (24%)
hri1	NP_594738.1	Pkinase	224..658	CDD:278497	107/436 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910