DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment EIF2AK2 and wee1

DIOPT Version :9

Sequence 1:	NP_001129123.1	Gene:	EIF2AK2 / 5610	HGNCID:	9437	Length:	551	Species:	Homo sapiens
Sequence 2:	NP_587933.1	Gene:	wee1 / 2539123	PomBaseID:	SPCC18B5.03	Length:	877	Species:	Schizosaccharomyces pombe

Alignment Length:	437	Identity:	99/437 - (22%)
Similarity:	186/437 - (42%)	Gaps:	123/437 - (28%)

- Green bases have known domain annotations that are detailed below.

Human   163 LQILSEETSVKSDYLSSGSFATTCESQSNSLVTSTLASESSSEGDFS----ADTSEINSNSDSLN 223
            |..||.:....:...:..:|..|.....:....|.:.|.::::..|:    ||.|:.:|:|.:|:
pombe   481 LPFLSNQRCPATPTRNPFAFENTVSIHMDGRQPSPIKSRNNNQMSFAMEEEADVSQPSSSSFTLS 545

Human   224 SSSLLMNGLRNNQRKAKRSLAPRFDLPDMKETKYTVDKRFGMDFKEIELIGSGGFGQVFKAKHRI 288
            ..|.|.:.      |...|            |.:.:.:     |:.:.|:|||.|.:||:.:..:
pombe   546 FPSALTSS------KVSSS------------TSHLLTR-----FRNVTLLGSGEFSEVFQVEDPV 587

Human   289 DGKT--YVIK--RVKYNNEKAEREV-------KALAKLDHVNIVHYNGCWD--GFDYDPETSDDS 340
            : ||  |.:|  :||::..|....:       :||...||  ||.....|:  ||
pombe   588 E-KTLKYAVKKLKVKFSGPKERNRLLQEVSIQRALKGHDH--IVELMDSWEHGGF---------- 639

Human   341 LESSDYDPENSKNSSRSKTKCLFIQMEFCDKGTLEQWIEKRRGE--KLDKVLALELFEQITKGVD 403
                                 |::|:|.|:.|:|::::|: :|:  :||:....::..::..|:.
pombe   640 ---------------------LYMQVELCENGSLDRFLEE-QGQLSRLDEFRVWKILVEVALGLQ 682

Human   404 YIHSKKLIHRDLKPSNIFLVDTKQVKIGDFGLVTSLKNDGKRTRSKGTLRYMSPEQISSQDYGKE 468
            :||.|..:|.||||:|:.:.....:||||||: .|:....:....:|...|::||.:::..|.|.
pombe   683 FIHHKNYVHLDLKPANVMITFEGTLKIGDFGM-ASVWPVPRGMEREGDCEYIAPEVLANHLYDKP 746

Human   469 VDLYALGLILAELLHVCDTAFETS---------KFFTDLRDGIISD------------IFDKKEK 512
            .|:::||:          |.||.:         :.:..||.|.:||            :.....:
pombe   747 ADIFSLGI----------TVFEAAANIVLPDNGQSWQKLRSGDLSDAPRLSSTDNGSSLTSSSRE 801

Human   513 T-------------LLQKLLSKKPEDRPNTSEILRTLTV-WKKSPEK 545
            |             :::.:||.:|.:||...:||.|..| |.:...|
pombe   802 TPANSIIGQGGLDRVVEWMLSPEPRNRPTIDQILATDEVCWVEMRRK 848

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
EIF2AK2	NP_001129123.1	(Microbial infection) Interaction with HCV NS5A. /evidence=ECO:0000269\|PubMed:17267064	2..180		3/16 (19%)
		DSRM	14..>59	CDD:214634
		DSRM	101..166	CDD:214634	1/2 (50%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	202..222		6/23 (26%)
		STKc_EIF2AK2_PKR	260..536	CDD:270949	76/324 (23%)
		Interaction with TRAF5. /evidence=ECO:0000269\|PubMed:15121867	266..551		80/330 (24%)
		2 X 13 AA approximate repeats	331..357		0/25 (0%)
wee1	NP_587933.1	PTKc_Wee1_fungi	565..838	CDD:270954	76/323 (24%)
wee1	NP_587933.1	Pkinase	566..836	CDD:278497	75/315 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910