DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment MAP2K7 and mek-1

DIOPT Version :9

Sequence 1:	XP_006722863.1	Gene:	MAP2K7 / 5609	HGNCID:	6847	Length:	442	Species:	Homo sapiens
Sequence 2:	NP_001024771.1	Gene:	mek-1 / 181004	WormBaseID:	WBGene00003185	Length:	347	Species:	Caenorhabditis elegans

Alignment Length:	368	Identity:	176/368 - (47%)
Similarity:	238/368 - (64%)	Gaps:	34/368 - (9%)

- Green bases have known domain annotations that are detailed below.

Human    61 LPLANDGGSRSPSSESSPQHPTPPARPRHMLGLPSTLFTPRSMESIEIDQKLQEIMKQ----TGY 121
            |.:...||......|...|....|| |.|    ||     ||..    |..::.:|||    :||
Worm     7 LGMGRPGGLGGLGGEPIMQQMPQPA-PHH----PS-----RSSN----DHNVKNLMKQAEENSGY 57

Human   122 LTIGGQRYQAEINDLENLGEMGSGTCGQVWKMRFRKTGHVIAVKQMRRSGNKEENKRILMDLDVV 186
            ||:.|.|.:|::.:|:.:.::|.|:||.|.|.|::..  ::|||.|.|:.|..|..||||||||:
Worm    58 LTLQGNRRKADLKELQFVEDIGHGSCGTVTKCRYKSV--IMAVKTMPRTSNSYEMSRILMDLDVI 120

Human   187 LKSHDCPYIVQCFGTFITNTDVFIAMELMGTCAEKLKKRMQGPIPERILGKMTVAIVKALYYLKE 251
            ..|.||||||:|||.||||.||.:.||.|.||.::|..|::.||||||:||::|:|:|||:|||.
Worm   121 CLSFDCPYIVRCFGYFITNFDVRVCMECMATCLDRLLIRIKQPIPERIIGKLSVSIIKALHYLKT 185

Human   252 KHGVIHRDVKPSNILLDERGQIKLCDFGISGRLVDSKAKTRSAGCAAYMAPERIDPPDPTKPDYD 316
            ||.::||||||||||||..|.||||||||:|||::|:|.::.|||..||.|||:||.:  ...||
Worm   186 KHQIMHRDVKPSNILLDWSGVIKLCDFGIAGRLIESRAHSKQAGCPLYMGPERLDPNN--FDSYD 248

Human   317 IRADVWSLGISLPCPSPSQVELATGQFPYKNCKTDFEVLTKVLQEEPPLL-PGHMGFSGDFQSFV 380
            ||:||||.|::|       |||||||:||..  |:|::::|:|.:|||.| |..  ||.||...|
Worm   249 IRSDVWSFGVTL-------VELATGQYPYAG--TEFDMMSKILNDEPPRLDPAK--FSPDFCQLV 302

Human   381 KDCLTKDHRKRPKYNKLLEHSFIKRYETLEVDVASWFKDVMAK 423
            :.||.:|...||.|:.||:|.|:..:|.:|.||..||.|||.:
Worm   303 ESCLQRDPTMRPNYDMLLQHPFVVHHEKIETDVEEWFADVMGE 345

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MAP2K7	XP_006722863.1	PKc_MKK7	120..423	CDD:270791	159/303 (52%)
mek-1	NP_001024771.1	PKc_MKK7	56..345	CDD:270791	159/303 (52%)
mek-1	NP_001024771.1	S_TKc	73..325	CDD:214567	141/266 (53%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C161452440
Domainoid	1	1.000	286	1.000	Domainoid score	I955
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H56548
Inparanoid	1	1.050	328	1.000	Inparanoid score	I1655
Isobase	1	0.950	-	0	Normalized mean entropy	S1923
OMA	1	1.010	-	-		QHG49397
OrthoDB	1	1.010	-	-		D470057at33208
OrthoFinder	1	1.000	-	-		FOG0005845
OrthoInspector	1	1.000	-	-		oto21980
orthoMCL	1	0.900	-	-		OOG6_107093
Panther	1	1.100	-	-	LDO	PTHR48013
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3854
SonicParanoid	1	1.000	-	-		X4836
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	15	14.890