Protein Alignment MAP2K6 and GckIII

DIOPT Version :10

• Sequence 1: XP_047292366.1
• Gene: MAP2K6 / 5608
• HGNCID: 6846
• Length: 337
• Species: Homo sapiens
• Sequence 2: NP_650596.1
• Gene: GckIII / 42064
• FlyBaseID: FBgn0266465
• Length: 642
• Species: Drosophila melanogaster
• Alignment Length: 279
• Identity: 90/279 - (32%)
• Similarity: 147/279 - (52%)
• Gaps: 27/279 - (9%)

Human    62 LGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLD---ISMRTVDCPFTVTFYGALF 123
            :|:|::|.|.|.....:.|::|:|    .::.:|.:..:.|:.   :.:...|.|:...:||:..
  Fly    19 IGKGSFGEVFKGIDNRTQQVVAIK----IIDLEEAEDEIDDIQQEIMVLSQCDSPYVTKYYGSFL 79

Human   124 REGDVWICMELM--DTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLHSKLSVIHRDVKPS 186
            :...:||.||.:  .::||      :.|..:..|..:|.|...::|.|::|||:.. :|||:|.:
  Fly    80 KGTKLWIIMEYLGGGSALD------LMKAGSFEEMHIGIILREVLKGLDYLHSERK-LHRDIKAA 137

Human   187 NVLINALGQVKMCDFGISGYLVDSVAK-TIDAGCKPYMAPERINPELNQKGYSVKSDIWSLGITM 250
            |||::..|.||:.|||::|.|.::.:| ....|...:||||.|    .|..|..|:||||||||.
  Fly   138 NVLLSEQGDVKLADFGVAGQLTNTTSKRNTFVGTPFWMAPEVI----KQSQYDAKADIWSLGITA 198

Human   251 IELAILRFPYDSWGTPFQQLKQVVEEPSPQLPADKFSAEFVDFTSQCLKKNSKERPTYPELMQHP 315
            |||| ...|.:|...|.:.|..:.:...||| ...::..|.||...||.|:.:.|||..||:::|
  Fly   199 IELA-KGEPPNSELHPMRVLFLIPKNNPPQL-TGSYTKSFKDFVEACLNKDPENRPTAKELLKYP 261

Human   316 FFTLHESKGTDVASFVKLI 334
            |.    .|....|..:.||
  Fly   262 FI----KKAKKNAYLIDLI 276

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MAP2K6	XP_047292366.1	PKc_MKK3_6	54..336	CDD:173729	90/279 (32%)
GckIII	NP_650596.1	STKc_MST3_like	12..283	CDD:270786	90/279 (32%)