DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment MAP2K6 and lic

DIOPT Version :9

Sequence 1:	XP_011523328.1	Gene:	MAP2K6 / 5608	HGNCID:	6846	Length:	337	Species:	Homo sapiens
Sequence 2:	NP_477162.1	Gene:	lic / 32257	FlyBaseID:	FBgn0261524	Length:	334	Species:	Drosophila melanogaster

Alignment Length:	312	Identity:	189/312 - (60%)
Similarity:	243/312 - (77%)	Gaps:	0/312 - (0%)

- Green bases have known domain annotations that are detailed below.

Human    24 EQPQTSSTPPRDLDSKACISIGNQNFEVKADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIR 88
            ::|:.:..|||:|||:|.|.||::.|::.||.||.|.:|||||||:|:||||..:..::|||||.
  Fly    14 KEPEAAIVPPRNLDSRATIQIGDRTFDIDADSLEKICDLGRGAYGIVDKMRHKQTDTVLAVKRIP 78

Human    89 ATVNSQEQKRLLMDLDISMRTVDCPFTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTI 153
            .|||.:||.||:||||||||:.|||:||.||||::||||||||||:|.|||||||.:|......:
  Fly    79 MTVNIREQHRLVMDLDISMRSSDCPYTVHFYGAMYREGDVWICMEVMSTSLDKFYPKVFLHDLRM 143

Human   154 PEDILGKIAVSIVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDSVAKTIDAG 218
            .|.:|||||:|:|.||.:||::|.||||||||||:|||..||||:||||||||||||:|||||||
  Fly   144 EESVLGKIAMSVVSALHYLHAQLKVIHRDVKPSNILINRAGQVKICDFGISGYLVDSIAKTIDAG 208

Human   219 CKPYMAPERINPELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPSPQLPA 283
            ||||||||||:|:.|...|.::||:|||||.|||:|..|:|||:|.|||:||:||||:..|:||.
  Fly   209 CKPYMAPERIDPQGNPAQYDIRSDVWSLGIGMIEMATGRYPYDNWRTPFEQLRQVVEDSPPRLPE 273

Human   284 DKFSAEFVDFTSQCLKKNSKERPTYPELMQHPFFTLHESKGTDVASFVKLIL 335
            ..||.||.||.:.||:|....||.|.:|::|.|...|..:.||::.||..||
  Fly   274 GTFSPEFEDFIAVCLQKEYMARPNYEQLLKHSFIVEHLQRNTDISEFVARIL 325

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MAP2K6	XP_011523328.1	PKc_MKK3_6	54..336	CDD:173729	176/282 (62%)
MAP2K6	XP_011523328.1	S_TKc	57..317	CDD:214567	166/259 (64%)
lic	NP_477162.1	PKc_MKK3_6	44..326	CDD:173729	176/282 (62%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	354	1.000	Domainoid score	I1001
eggNOG	1	0.900	-	-		E1_KOG0984
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	404	1.000	Inparanoid score	I1913
Isobase	1	0.950	-	0	Normalized mean entropy	S1024
OMA	1	1.010	-	-		QHG51923
OrthoDB	1	1.010	-	-		D470057at33208
OrthoFinder	1	1.000	-	-		FOG0001217
OrthoInspector	1	1.000	-	-		otm40985
orthoMCL	1	0.900	-	-		OOG6_101822
Panther	1	1.100	-	-	LDO	PTHR48013
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2221
SonicParanoid	1	1.000	-	-		X2955
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.820