Protein Alignment MAP2K6 and hep

DIOPT Version :9

• Sequence 1: XP_011523328.1
• Gene: MAP2K6 / 5608
• HGNCID: 6846
• Length: 337
• Species: Homo sapiens
• Sequence 2: NP_001368982.1
• Gene: hep / 32256
• FlyBaseID: FBgn0010303
• Length: 1294
• Species: Drosophila melanogaster
• Alignment Length: 332
• Identity: 144/332 - (43%)
• Similarity: 205/332 - (61%)
• Gaps: 11/332 - (3%)

Human     9 GKKRNPGLKIPKEAFEQPQTSSTPPR---DLDSKACISIGNQNFEVKADDLEPIMELGRGAYGVV 70
            |..|...:.:|......|..|.|..:   .::....::|..:.:....:||:.:.:||.|..|.|
  Fly   147 GLNRTRPVILPLPTPPHPPVSETDMKLKIIMEQTGKLNINGRQYPTDINDLKHLGDLGNGTSGNV 211

Human    71 EKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMRTVDCPFTVTFYGALFREGDVWICMELM 135
            .||.|:.|..|:|||::|.|.|::|.||:|||||:.:::.||.:.|...|...|:.|||||||||
  Fly   212 VKMMHLSSNTIIAVKQMRRTGNAEENKRILMDLDVVLKSHDCKYIVKCLGCFVRDPDVWICMELM 276

Human   136 DTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCD 200
            ....||..|  :.| :.:||.||||:.|:.|.||.:|..|..||||||||||:||:..|.:|:||
  Fly   277 SMCFDKLLK--LSK-KPVPEQILGKVTVATVNALSYLKDKHGVIHRDVKPSNILIDERGNIKLCD 338

Human   201 FGISGYLVDSVAKTIDAGCKPYMAPERINPELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGT 265
            |||||.||||.|.|..|||..|||||||:|:  :..|.:::|:||||||::|||..|.||:...|
  Fly   339 FGISGRLVDSKANTRSAGCAAYMAPERIDPK--KPKYDIRADVWSLGITLVELATARSPYEGCNT 401

Human   266 PFQQLKQVVEEPSPQLPADK---FSAEFVDFTSQCLKKNSKERPTYPELMQHPFFTLHESKGTDV 327
            .|:.|.:|::...|.||..:   ||.:|.||..:||.||.::||.||||:..||..::||...||
  Fly   402 DFEVLTKVLDSEPPCLPYGEGYNFSQQFRDFVIKCLTKNHQDRPKYPELLAQPFIRIYESAKVDV 466

Human   328 ASFVKLI 334
            .::.:.|
  Fly   467 PNWFQSI 473

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MAP2K6	XP_011523328.1	PKc_MKK3_6	54..336	CDD:173729	137/284 (48%)
		S_TKc	57..317	CDD:214567	129/262 (49%)
hep	NP_001368982.1	PKc_MKK7	181..476	CDD:270791	138/298 (46%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D470057at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.920