Protein Alignment MAP2K5 and lic

DIOPT Version :10

• Sequence 1: NP_660143.1
• Gene: MAP2K5 / 5607
• HGNCID: 6845
• Length: 448
• Species: Homo sapiens
• Sequence 2: NP_477162.1
• Gene: lic / 32257
• FlyBaseID: FBgn0261524
• Length: 334
• Species: Drosophila melanogaster
• Alignment Length: 283
• Identity: 121/283 - (42%)
• Similarity: 167/283 - (59%)
• Gaps: 23/283 - (8%)

Human   172 LGHGNGGTVYKAYHVPSGKILAVKVILLDITLELQKQIMSELEI-LYKCDSSYIIGFYGAFFVEN 235
            ||.|..|.|.|..|..:..:||||.|.:.:.:..|.:::.:|:| :...|..|.:.||||.:.|.
  Fly    52 LGRGAYGIVDKMRHKQTDTVLAVKRIPMTVNIREQHRLVMDLDISMRSSDCPYTVHFYGAMYREG 116

Human   236 RISICTEFMDGGSLDVY--------RKMPEHVLGRIAVAVVKGLTYLWS-LKILHRDVKPSNMLV 291
            .:.||.|.| ..|||.:        .:|.|.|||:||::||..|.||.: ||::||||||||:|:
  Fly   117 DVWICMEVM-STSLDKFYPKVFLHDLRMEESVLGKIAMSVVSALHYLHAQLKVIHRDVKPSNILI 180

Human   292 NTRGQVKLCDFGVSTQLVNSIAKTY-VGTNAYMAPERISGE----QYGIHSDVWSLGISFMELAL 351
            |..||||:||||:|..||:|||||. .|...|||||||..:    ||.|.||||||||..:|:|.
  Fly   181 NRAGQVKICDFGISGYLVDSIAKTIDAGCKPYMAPERIDPQGNPAQYDIRSDVWSLGIGMIEMAT 245

Human   352 GRFPYPQIQKNQGSLMPLQLLQCIVDEDSPVLPVGEFSEPFVHFITQCMRKQPKERPAPEELMGH 416
            ||:||...:      .|.:.|:.:|::..|.||.|.||..|..||..|::|:...||..|:|:.|
  Fly   246 GRYPYDNWR------TPFEQLRQVVEDSPPRLPEGTFSPEFEDFIAVCLQKEYMARPNYEQLLKH 304

Human   417 PFIVQFNDGNAAVVSMWVCRALE 439
            .|||:....|.. :|.:|.|.|:
  Fly   305 SFIVEHLQRNTD-ISEFVARILD 326

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MAP2K5	NP_660143.1	PB1_Map2k5	17..107	CDD:99717
		Interaction with MAPK7. /evidence=ECO:0000250	18..25
		Interaction with MAP3K2/MAP3K3. /evidence=ECO:0000250	64..68
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	116..144
		Interaction with MAPK7. /evidence=ECO:0000250	117..131
		PKc_MKK5	164..442	CDD:132950	121/283 (43%)
lic	NP_477162.1	PKc_MKK3_6	44..326	CDD:173729	120/281 (43%)