DRSC/TRiP Functional Genomics Resources

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Protein Alignment MAP2K3 and mbt

DIOPT Version :10

Sequence 1:XP_016880346.2 Gene:MAP2K3 / 5606 HGNCID:6843 Length:466 Species:Homo sapiens
Sequence 2:NP_523375.2 Gene:mbt / 32631 FlyBaseID:FBgn0025743 Length:639 Species:Drosophila melanogaster


Alignment Length:522 Identity:126/522 - (24%)
Similarity:197/522 - (37%) Gaps:118/522 - (22%)


- Green bases have known domain annotations that are detailed below.


Human     4 PASSQPASMPQSKGRRSRPGPRPDPAPNLGPGCKPRPFFGPTPSCSRPGSGVRSRNPFLFGVPGP 68
            |.:|..|   :|...||...||.....|:.|......  || |:...||.|..|...  |..||.
  Fly   133 PKTSHVA---RSNSLRSSSPPRVRRVANVPPSVPEEE--GP-PAAGTPGVGGASSGG--FKPPGA 189

Human    69 AP--------AWALTWTPTLGLGT-----------------ALRPEITQAGP----RLGLCSAHP 104
            .|        |.|...|..|.:.|                 ...|:..|..|    ..|..|.|.
  Fly   190 HPSLLYNSQHAHANGATGPLAVRTDQTNLQQYRSNLAPPSGGSMPQQQQTSPVGSVASGTRSNHS 254

Human   105 IQVRSLILTSFGPYGCSL----------------------DMNSPSLLPQRDP--------GKSK 139
                   .|:.|..|.|.                      |.|...|.|...|        .||.
  Fly   255 -------HTNNGNSGGSYPPMYPTSHQQQQQQQQQAKQGGDQNQNPLHPHAHPHPHHHQHLAKSA 312

Human   140 RKKD----------LRISCMSKPPAPNPTPPRNLDSRTF-------ITIGDRNFEVEADDLVTIS 187
            .:..          .:.|..|...|..|...:.|....|       ::.||     ..::|...:
  Fly   313 SRASSSSGGASSAAQQASGASGGAAGQPKQDQRLTHEQFRAALQMVVSAGD-----PRENLDHFN 372

Human   188 ELGRGAYGVVEKVRHAQSGTIMAVKRIRATVNSQEQKRLLMDLDINMRTVDCFYTVTFYGALFRE 252
            ::|.|:.|.|.......:|..:|||::  .:..|:::.||.:..:.||.......|..|.:....
  Fly   373 KIGEGSTGTVCIATDKSTGRQVAVKKM--DLRKQQRRELLFNEVVIMRDYHHPNIVETYSSFLVN 435

Human   253 GDVWICMELMD----TSLDKFYRKVLDKNMTIPEDILGEIAVSIVRALEHLHSKLSVIHRDVKPS 313
            .::|:.||.::    |.:....|        :.|:.:..:....::||.:|||: .|||||:|..
  Fly   436 DELWVVMEYLEGGALTDIVTHSR--------MDEEQIATVCKQCLKALAYLHSQ-GVIHRDIKSD 491

Human   314 NVLINKEGHVKMCDFGISGYLVDSVAKTMDAGCKPY-MAPERINPELNQKGYNVKSDVWSLGITM 377
            ::|:..:|.||:.|||....:...:.|.......|| |:||.|    ::..|..:.|:|||||.:
  Fly   492 SILLAADGRVKLSDFGFCAQVSQELPKRKSLVGTPYWMSPEVI----SRLPYGPEVDIWSLGIMV 552

Human   378 IEMAILRFPYESWGTPFQQLKQVVEEPSPQLP-ADRFSPEFVDFTAQCLRKNPAERMSYLELMEH 441
            |||.....|:.: ..|.|.::::.:...|.|. |.:.||....|..:.|.::||:|.:..||:.|
  Fly   553 IEMVDGEPPFFN-EPPLQAMRRIRDMQPPNLKNAHKVSPRLQSFLDRMLVRDPAQRATAAELLAH 616

Human   442 PF 443
            ||
  Fly   617 PF 618

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
MAP2K3XP_016880346.2 PKc_MKK3_6 181..463 CDD:173729 75/269 (28%)
mbtNP_523375.2 CRIB_PAK_like 9..54 CDD:238526
STKc_PAK_II 360..620 CDD:270815 77/280 (28%)
Blue background indicates that the domain is not in the aligned region.

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