Protein Alignment MAP2K2 and mek-2

DIOPT Version :9

• Sequence 1: XP_016882478.1
• Gene: MAP2K2 / 5605
• HGNCID: 6842
• Length: 512
• Species: Homo sapiens
• Sequence 2: NP_491087.1
• Gene: mek-2 / 171872
• WormBaseID: WBGene00003186
• Length: 387
• Species: Caenorhabditis elegans
• Alignment Length: 347
• Identity: 195/347 - (56%)
• Similarity: 245/347 - (70%)
• Gaps: 15/347 - (4%)

Human     4 RRKPVLPALTINPTIAEGPSPTSEGASEAN-LVDLQKKLEELELDEQQKKRLEAFLTQKAKVGEL 67
            ||.|:  .|::.||:.|........|.||. .|.|:::|::|.|.|.|.:||..||..|..:.||
 Worm     6 RRNPL--GLSLPPTVNEQSESGEATAEEATATVPLEEQLKKLGLTEPQTQRLSEFLQVKEGIKEL 68

Human    68 KDDDFERISELGAGNGGVVTKVQHRPSGLIMARKLIHLEIKPAIRNQIIRELQVLHECNSPYIVG 132
            .:|..:...|||.||||||.|..||.:|:||||||:||||||::|.||::||.|||:||||:|||
 Worm    69 SEDMLQTEGELGHGNGGVVNKCVHRKTGVIMARKLVHLEIKPSVRQQIVKELAVLHKCNSPFIVG 133

Human   133 FYGAFYSDGEISICMEHMDGGSLDQVLKEAKRIPEEILGKVSIAVLRGLAYLREKHQIMHRDVKP 197
            |||||..:.:||||||:|||.|||.|||:..|:||:.:|::|:||:|||.||:::.:|:||||||
 Worm   134 FYGAFVDNNDISICMEYMDGLSLDIVLKKVGRLPEKFVGRISVAVVRGLTYLKDEIKILHRDVKP 198

Human   198 SNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMAPERLQGTHYSVQSDIWSMGLSLVELAV 262
            ||:||||.||||||||||||.|||||||||||||||||||||.|:||::.|||||.|||||||.:
 Worm   199 SNMLVNSNGEIKLCDFGVSGMLIDSMANSFVGTRSYMAPERLTGSHYTISSDIWSFGLSLVELLI 263

Human   263 GRYPIPPPDAKELEAIFGRPVVDGEEGEPHSI-SPRPRPPGRPVSGHGMDSRPAMAIFELLDYIV 326
            ||||:|.|...|...:|.  |.:.|.....|: .|...||..|.|         |||||:|||||
 Worm   264 GRYPVPAPSQAEYATMFN--VAENEIELADSLEEPNYHPPSNPAS---------MAIFEMLDYIV 317

Human   327 NEPPPKLPNGVFTPDFQEFVNK 348
            |.|||.||...||.:...||:|
 Worm   318 NGPPPTLPKRFFTDEVIGFVSK 339

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MAP2K2	XP_016882478.1	None
mek-2	NP_491087.1	PKc_MEK	71..380	CDD:132946	171/280 (61%)
		S_TKc	74..360	CDD:214567	170/277 (61%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C161456197
Domainoid	1	1.000	360	1.000	Domainoid score	I539
eggNOG	1	0.900	-	-		E1_KOG0581
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	391	1.000	Inparanoid score	I1274
Isobase	1	0.950	-	0	Normalized mean entropy	S924
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D566457at33208
OrthoFinder	1	1.000	-	-		FOG0000715
OrthoInspector	1	1.000	-	-		otm16100
orthoMCL	1	0.900	-	-		OOG6_100914
Panther	1	1.100	-	-	LDO	PTHR48013
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2221
SonicParanoid	1	1.000	-	-		X438
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	15	14.740