Protein Alignment MAP2K1 and map2k1

DIOPT Version :10

• Sequence 1: NP_002746.1
• Gene: MAP2K1 / 5604
• HGNCID: 6840
• Length: 393
• Species: Homo sapiens
• Sequence 2: NP_998584.2
• Gene: map2k1 / 406728
• ZFINID: ZDB-GENE-040426-2759
• Length: 395
• Species: Danio rerio
• Alignment Length: 393
• Identity: 347/393 - (88%)
• Similarity: 371/393 - (94%)
• Gaps: 3/393 - (0%)

Human     3 KKKPTPIQLNPAPDGSAVNGTSSAETNLEALQKKLEELELDEQQRKRLEAFLTQKQKVGELKDDD 67
            ::||.||||||.|||:|:|||.:.||||||||||||||||||||:||||||||||||||||||||
Zfish     4 RRKPEPIQLNPIPDGNAINGTGATETNLEALQKKLEELELDEQQKKRLEAFLTQKQKVGELKDDD 68

Human    68 FEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNSPYIVGFYGA 132
            ||||||||||||||||||.|:|||.:|||||||||||||||||||||||||||||||||||||||
Zfish    69 FEKISELGAGNGGVVFKVLHRPSGFIMARKLIHLEIKPAIRNQIIRELQVLHECNSPYIVGFYGA 133

Human   133 FYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREKHKIMHRDVKPSNIL 197
            ||||||||||||:||||||||.|||||:|||||||||||||||||:|||||||||||||||||||
Zfish   134 FYSDGEISICMENMDGGSLDQCLKKAGKIPEQILGKVSIAVIKGLSYLREKHKIMHRDVKPSNIL 198

Human   198 VNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHYSVQSDIWSMGLSLVEMAVGRYP 262
            ||||||||||||||||||||||||||||||||||||||||||||||.|||||||||||||:||:|
Zfish   199 VNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHYSVQPDIWSMGLSLVEMAIGRFP 263

Human   263 IPPPDAKELELMFGCQVEGD--AAETPPRPRTPGRPLSSYGMDSRPPMAIFELLDYIVNEPPPKL 325
            ||||||||||.:||..:|||  |::|.|:||.||||.||||.|||||||||||||||||||||||
Zfish   264 IPPPDAKELEQIFGQPLEGDPSASDTSPKPRPPGRPGSSYGPDSRPPMAIFELLDYIVNEPPPKL 328

Human   326 PSGVFSLEFQDFVNKCLIKNPAERADLKQLMVHAFIKRSDAEEVDFAGWLCSTIGLNQPSTPTHA 390
            || :|..||||||||||||||||||||||||||:|||.|:|||||||||||||||||||:||||:
Zfish   329 PS-IFGAEFQDFVNKCLIKNPAERADLKQLMVHSFIKDSEAEEVDFAGWLCSTIGLNQPATPTHS 392

Human   391 AGV 393
            .|:
Zfish   393 VGM 395

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MAP2K1	NP_002746.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..27		15/23 (65%)
		PKc_MEK1	62..380	CDD:270816	287/319 (90%)
		RAF1-binding. /evidence=ECO:0000269|PubMed:20956560	270..307		24/38 (63%)
map2k1	NP_998584.2	PKc_MEK1	63..382	CDD:270816	287/319 (90%)