Protein Alignment MAP2K1 and byr1

DIOPT Version :10

• Sequence 1: NP_002746.1
• Gene: MAP2K1 / 5604
• HGNCID: 6840
• Length: 393
• Species: Homo sapiens
• Sequence 2: NP_593026.1
• Gene: byr1 / 2542137
• PomBaseID: SPAC1D4.13
• Length: 340
• Species: Schizosaccharomyces pombe
• Alignment Length: 381
• Identity: 152/381 - (39%)
• Similarity: 217/381 - (56%)
• Gaps: 61/381 - (16%)

Human     3 KKKPTPIQLNP-----APDG----SAVNGTSSAETNLEALQKKLEELELDEQQRKRLEAFLTQKQ 58
            ::.|..:.|||     :.|.    ..:|...|.|:|:||..::...:       .|..|:
pombe     5 RRNPKGLVLNPNASVKSSDNDHKEELINNQKSFESNVEAFMEQCAHM-------NRRPAW----- 57

Human    59 KVGELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNS 123
             :.:|.:...|.:..||.||||.|..|.|:  .:.||||.:::.....::.||:|||.|||.|.|
pombe    58 -ISDLDNSSLEVVRHLGEGNGGAVSLVKHR--NIFMARKTVYVGSDSKLQKQILRELGVLHHCRS 119

Human   124 PYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREKHKIMH 188
            ||||||||||.....||:|||:||.||||.:|::.|.||..||||:..:::|||.||.....|:|
pombe   120 PYIVGFYGAFQYKNNISLCMEYMDCGSLDAILREGGPIPLDILGKIINSMVKGLIYLYNVLHIIH 184

Human   189 RDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHYSVQSDIWSMGLSL 253
            ||:||||::||||||||||||||||:|::|:|.:||||.:||||||::|..|:|:|||||:|:|:
pombe   185 RDLKPSNVVVNSRGEIKLCDFGVSGELVNSVAQTFVGTSTYMSPERIRGGKYTVKSDIWSLGISI 249

Human   254 VEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRPLSSYGMDSRPPMAIFELLDYIV 318
            :|:|          .:||                        |.|...:|.  .:.|.:||..||
pombe   250 IELA----------TQEL------------------------PWSFSNIDD--SIGILDLLHCIV 278

Human   319 NEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVHAFIKRSDAEEVDFAGW 374
            .|.||:|||. |..:.:.||:.||.|:|..||..:||....:.:::....||.|.|
pombe   279 QEEPPRLPSS-FPEDLRLFVDACLHKDPTLRASPQQLCAMPYFQQALMINVDLASW 333

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MAP2K1	NP_002746.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..27		7/32 (22%)
		PKc_MEK1	62..380	CDD:270816	139/313 (44%)
		RAF1-binding. /evidence=ECO:0000269|PubMed:20956560	270..307		5/36 (14%)
byr1	NP_593026.1	PKc_Byr1_like	60..334	CDD:270792	139/313 (44%)