Protein Alignment MAP2K1 and Map2k1

DIOPT Version :10

• Sequence 1: NP_002746.1
• Gene: MAP2K1 / 5604
• HGNCID: 6840
• Length: 393
• Species: Homo sapiens
• Sequence 2: NP_113831.1
• Gene: Map2k1 / 170851
• RGDID: 70495
• Length: 393
• Species: Rattus norvegicus
• Alignment Length: 393
• Identity: 390/393 - (99%)
• Similarity: 392/393 - (99%)
• Gaps: 0/393 - (0%)

Human     1 MPKKKPTPIQLNPAPDGSAVNGTSSAETNLEALQKKLEELELDEQQRKRLEAFLTQKQKVGELKD 65
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat     1 MPKKKPTPIQLNPAPDGSAVNGTSSAETNLEALQKKLEELELDEQQRKRLEAFLTQKQKVGELKD 65

Human    66 DDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNSPYIVGFY 130
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat    66 DDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNSPYIVGFY 130

Human   131 GAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREKHKIMHRDVKPSN 195
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat   131 GAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREKHKIMHRDVKPSN 195

Human   196 ILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHYSVQSDIWSMGLSLVEMAVGR 260
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat   196 ILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHYSVQSDIWSMGLSLVEMAVGR 260

Human   261 YPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRPLSSYGMDSRPPMAIFELLDYIVNEPPPKL 325
            |||||||||||||:|||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat   261 YPIPPPDAKELELLFGCQVEGDAAETPPRPRTPGRPLSSYGMDSRPPMAIFELLDYIVNEPPPKL 325

Human   326 PSGVFSLEFQDFVNKCLIKNPAERADLKQLMVHAFIKRSDAEEVDFAGWLCSTIGLNQPSTPTHA 390
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat   326 PSGVFSLEFQDFVNKCLIKNPAERADLKQLMVHAFIKRSDAEEVDFAGWLCSTIGLNQPSTPTHA 390

Human   391 AGV 393
            |.:
  Rat   391 ASI 393

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MAP2K1	NP_002746.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..27		25/25 (100%)
		PKc_MEK1	62..380	CDD:270816	316/317 (100%)
		RAF1-binding. /evidence=ECO:0000269|PubMed:20956560	270..307		35/36 (97%)
Map2k1	NP_113831.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..27		25/25 (100%)
		PKc_MEK1	62..380	CDD:270816	316/317 (100%)
		RAF1-binding	270..307		35/36 (97%)