Protein Alignment MAPK13 and p38a

DIOPT Version :9

• Sequence 1: NP_002745.1
• Gene: MAPK13 / 5603
• HGNCID: 6875
• Length: 365
• Species: Homo sapiens
• Sequence 2: NP_001163711.1
• Gene: p38a / 42866
• FlyBaseID: FBgn0015765
• Length: 366
• Species: Drosophila melanogaster
• Alignment Length: 355
• Identity: 205/355 - (57%)
• Similarity: 261/355 - (73%)
• Gaps: 5/355 - (1%)

Human     1 MSLIRKKGFYKQDVNKTAWELPKTYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIF 65
            ||:...|.|||.|:|:|.||:|..|.....|||||||.|..|:.:.:...||||||:|||||.:.
  Fly     1 MSVSITKKFYKLDINRTEWEIPDIYQDLQPVGSGAYGQVSKAVVRGTNMHVAIKKLARPFQSAVH 65

Human    66 AKRAYRELLLLKHMQHENVIGLLDVFTP---ASSLRNFYDFYLVMPFMQTDLQKIMGME-FSEEK 126
            |||.||||.|||||.|||||||||:|.|   ..||.||...|||...|..||..|:.|: .|::.
  Fly    66 AKRTYRELRLLKHMDHENVIGLLDIFHPHPANGSLENFQQVYLVTHLMDADLNNIIRMQHLSDDH 130

Human   127 IQYLVYQMLKGLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARHADAEMTGYVVTRWYRAP 191
            :|:||||:|:||||||||||:||||||.|:||||||||:||||||||..:.||||||.|||||||
  Fly   131 VQFLVYQILRGLKYIHSAGVIHRDLKPSNIAVNEDCELRILDFGLARPTENEMTGYVATRWYRAP 195

Human   192 EVILSWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFVQKLNDKAAK 256
            |::|:||||:||||||||||||||::|.:|||.|.|::.||..|:::.|.|..||::|::.::|:
  Fly   196 EIMLNWMHYDQTVDIWSVGCIMAELITRRTLFPGTDHIHQLNLIMEMLGTPPAEFLKKISSESAR 260

Human   257 SYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQALTHPFFEPFRDPEEETEAQ 321
            |||||||....:.|..:|..|:|.|.||||||||||.:||:||.:||:||:.|.:.:|..| :..
  Fly   261 SYIQSLPPMKGRSFKNVFKNANPLAIDLLEKMLELDAEKRITAEEALSHPYLEKYAEPSVE-QTS 324

Human   322 QPFDDSLEHEKLTVDEWKQHIYKEIVNFSP 351
            .|:|.|.|...|.||:||:.||||:.||.|
  Fly   325 PPYDHSFEDMDLPVDKWKELIYKEVTNFKP 354

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MAPK13	NP_002745.1	STKc_p38delta	9..351	CDD:143384	201/345 (58%)
		TXY	180..182		1/1 (100%)
p38a	NP_001163711.1	STKc_p38	9..354	CDD:143356	201/345 (58%)
		S_TKc	25..312	CDD:214567	174/286 (61%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0660
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D324618at33208
OrthoFinder	1	1.000	-	-		FOG0000533
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24055
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X352
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	7	6.880