Protein Alignment MAPK13 and Cdk2

DIOPT Version :10

• Sequence 1: NP_002745.1
• Gene: MAPK13 / 5603
• HGNCID: 6875
• Length: 365
• Species: Homo sapiens
• Sequence 2: NP_524420.1
• Gene: Cdk2 / 42453
• FlyBaseID: FBgn0004107
• Length: 314
• Species: Drosophila melanogaster
• Alignment Length: 322
• Identity: 105/322 - (32%)
• Similarity: 165/322 - (51%)
• Gaps: 50/322 - (15%)

Human    31 VGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHMQHENVIGLLDVFTPAS 95
            :|.|.||.|..|....:|:.||:||:....::|.....|.||:.|||:::|.||:.|.||....:
  Fly    14 IGEGTYGIVYKARSNSTGQDVALKKIRLEGETEGVPSTAIREISLLKNLKHPNVVQLFDVVISGN 78

Human    96 SLRNFYDFYLVMPFMQTDLQKIMGME---FSEEKIQYLVYQMLKGLKYIHSAGVVHRDLKPGNLA 157
            :|      |::..::..||:|:|..:   |:.:.|:..::|:|..:.:.|:..::||||||.||.
  Fly    79 NL------YMIFEYLNMDLKKLMDKKKDVFTPQLIKSYMHQILDAVGFCHTNRILHRDLKPQNLL 137

Human   158 VNEDCELKILDFGLARHADAEMTGY---VVTRWYRAPEVILSWMHYNQTVDIWSVGCIMAEMLTG 219
            |:...::|:.||||||..:..|..|   |||.||||||::|....|:..|||||:|||.:||:..
  Fly   138 VDTAGKIKLADFGLARAFNVPMRAYTHEVVTLWYRAPEILLGTKFYSTGVDIWSLGCIFSEMIMR 202

Human   220 KTLFKGKDYLDQLTQILKVTGVPGTEFVQKLNDKAAKSYIQSLPQTPRKDFTQLFPR-------- 276
            ::||.|...:|||.:|.:....|         |:.....:..||     ||...|||
  Fly   203 RSLFPGDSEIDQLYRIFRTLSTP---------DETNWPGVTQLP-----DFKTKFPRWEGTNMPQ 253

Human   277 --ASPQAADLLEKMLELDVDKRLTAAQALTHPFFEPFRDPEEETEAQQPFDDSLEHEKLTVD 336
              ...:|.:|:..||..|.:.|::|..||.|.:|...:              .::|..|.||
  Fly   254 PITEHEAHELIMSMLCYDPNLRISAKDALQHAYFRNVQ--------------HVDHVALPVD 301

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MAPK13	NP_002745.1	STKc_p38delta	9..351	CDD:143384	105/322 (33%)
		TXY	180..182		0/1 (0%)
Cdk2	NP_524420.1	STKc_CDK1_CdkB_like	8..287	CDD:270829	100/292 (34%)