Protein Alignment MAPK13 and nmo

DIOPT Version :10

• Sequence 1: NP_002745.1
• Gene: MAPK13 / 5603
• HGNCID: 6875
• Length: 365
• Species: Homo sapiens
• Sequence 2: NP_001356976.1
• Gene: nmo / 38890
• FlyBaseID: FBgn0011817
• Length: 439
• Species: Drosophila melanogaster
• Alignment Length: 346
• Identity: 131/346 - (37%)
• Similarity: 198/346 - (57%)
• Gaps: 33/346 - (9%)

Human    31 VGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHMQHENVIGLLDVFTPAS 95
            :|.||:|.|.:..|.|.|.:||:|||...|||.:.:||.:|||.:|...:||||:..||:..| .
  Fly    46 IGYGAFGVVWAVTDPRDGRRVALKKLPNVFQSLVSSKRVFRELKMLCFFKHENVLSALDILQP-P 109

Human    96 SLRNFYDFYLVMPFMQTDLQKIM--GMEFSEEKIQYLVYQMLKGLKYIHSAGVVHRDLKPGNLAV 158
            .|..|.:.|::...:|:||.||:  ....|.:.|:..:||:|:||||:|||.::|||:|||||.|
  Fly   110 HLDFFQEIYVITELLQSDLHKIIVSPQHLSADHIKVFLYQILRGLKYLHSARILHRDIKPGNLLV 174

Human   159 NEDCELKILDFGLARHADAE----MTGYVVTRWYRAPEVILSWMHYNQTVDIWSVGCIMAEMLTG 219
            |.:|.|||.||||||..:.:    ||..|||::|||||:::...||:..||:||||||..|:|..
  Fly   175 NSNCVLKICDFGLARVEEPDQAKHMTQEVVTQYYRAPEILMGARHYSSAVDVWSVGCIFGELLGR 239

Human   220 KTLFKGKDYLDQLTQILKVTGVPGTEFVQKLNDKAAKSYIQSLPQTPRKDFTQLF---PRASPQA 281
            :.||:.::.:.||..|.::.|.|..|.::...:.|....::..|:.|  .|:.|:   ..|:.:|
  Fly   240 RILFQAQNPVQQLELITELLGTPTMEDMRHACEGARTHMLRRAPKPP--SFSVLYTLSSHATHEA 302

Human   282 ADLLEKMLELDVDKRLTAAQALTHPFFEPFR---------------------DPEEETEAQQPFD 325
            ..||.:||..|.|||::...||.||:.:..|                     ..:.|..|.||||
  Fly   303 VHLLCQMLVFDPDKRISVTDALAHPYLDEGRLRYHSCMCKCCFTTSAGMRQYTADFEPSAGQPFD 367

Human   326 DSLEHEKLTVDEWKQHIYKEI 346
            |..|.:..:|.:.|:.::|.|
  Fly   368 DLWERKLTSVQQVKEEMHKFI 388

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MAPK13	NP_002745.1	STKc_p38delta	9..351	CDD:143384	131/346 (38%)
		TXY	180..182		1/1 (100%)
nmo	NP_001356976.1	STKc_NLK	39..411	CDD:173748	131/346 (38%)