Protein Alignment MAPK13 and Cdk5

DIOPT Version :10

• Sequence 1: NP_002745.1
• Gene: MAPK13 / 5603
• HGNCID: 6875
• Length: 365
• Species: Homo sapiens
• Sequence 2: NP_477080.1
• Gene: Cdk5 / 36727
• FlyBaseID: FBgn0013762
• Length: 294
• Species: Drosophila melanogaster
• Alignment Length: 289
• Identity: 106/289 - (36%)
• Similarity: 158/289 - (54%)
• Gaps: 23/289 - (7%)

Human    31 VGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHMQHENVIGLLDVFTPAS 95
            :|.|.||:|....::.:.|.||:|::......|.....|.||:.|||.::|:|::.|:||.....
  Fly    10 IGEGTYGTVFKGRNRDTMEIVALKRVRLDEDDEGVPSSALREICLLKELKHKNIVRLIDVLHSDK 74

Human    96 SLRNFYDFYLVMPFMQTDLQKI---MGMEFSEEKIQYLVYQMLKGLKYIHSAGVVHRDLKPGNLA 157
            .|.      ||......||:|.   :..|......:..:.|:|:||.:.||..|:||||||.||.
  Fly    75 KLT------LVFEHCDQDLKKYFDSLNGEIDMAVCRSFMLQLLRGLAFCHSHNVLHRDLKPQNLL 133

Human   158 VNEDCELKILDFGLARHADAEMTGY---VVTRWYRAPEVILSWMHYNQTVDIWSVGCIMAEML-T 218
            :|::.|||:.||||||.....:..|   |||.|||.|:|:.....|..::|:||.|||:||:. .
  Fly   134 INKNGELKLADFGLARAFGIPVKCYSAEVVTLWYRPPDVLFGAKLYTTSIDMWSAGCILAELADA 198

Human   219 GKTLFKGKDYLDQLTQILKVTGVPGTEF---VQKLNDKAAKSYIQSLPQTPR-KDFTQLFPRASP 279
            |:.||.|.|.||||.:|.:|.|.|..:.   |..|:|..|      ||..|. ..::||.||.:.
  Fly   199 GRPLFPGSDVLDQLMKIFRVLGTPNEDSWPGVSHLSDYVA------LPSFPAITSWSQLVPRLNS 257

Human   280 QAADLLEKMLELDVDKRLTAAQALTHPFF 308
            :..|||:|:|....::|::|..|:.||:|
  Fly   258 KGRDLLQKLLICRPNQRISAEAAMQHPYF 286

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MAPK13	NP_002745.1	STKc_p38delta	9..351	CDD:143384	106/289 (37%)
		TXY	180..182		0/1 (0%)
Cdk5	NP_477080.1	STKc_CDK5	3..286	CDD:143344	105/287 (37%)