Protein Alignment MAPK10 and HOG1

DIOPT Version :9

• Sequence 1: NP_001304998.1
• Gene: MAPK10 / 5602
• HGNCID: 6872
• Length: 478
• Species: Homo sapiens
• Sequence 2: NP_013214.1
• Gene: HOG1 / 850803
• SGDID: S000004103
• Length: 435
• Species: Saccharomyces cerevisiae
• Alignment Length: 417
• Identity: 155/417 - (37%)
• Similarity: 234/417 - (56%)
• Gaps: 49/417 - (11%)

Human    45 DNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAY 109
            :.:|...::..:.|.:..||.:|.|:|.||.|:||:|.|.:..:.|||||:.:||.....|||.|
Yeast     4 NEEFIRTQIFGTVFEITNRYNDLNPVGMGAFGLVCSATDTLTSQPVAIKKIMKPFSTAVLAKRTY 68

Human   110 RELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQME-LDHERMSYLLYQM 173
            |||.|:|.:.|:|:|.|.::|     |...:|:|.|.||...:|.:::|.. |:.:.:.|.|||:
Yeast    69 RELKLLKHLRHENLICLQDIF-----LSPLEDIYFVTELQGTDLHRLLQTRPLEKQFVQYFLYQI 128

Human   174 LCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVIL-G 237
            |.|:|::||||:||||||||||::..:|.|||.||||||....  .||.||.||||||||::| .
Yeast   129 LRGLKYVHSAGVIHRDLKPSNILINENCDLKICDFGLARIQDP--QMTGYVSTRYYRAPEIMLTW 191

Human   238 MGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKL--QPTVRNYVEN 300
            ..|...|||||.|||..||:..|.||||:|::.|::.:.:.||:|..:.:..:  :.|:: :|.:
Yeast   192 QKYDVEVDIWSAGCIFAEMIEGKPLFPGKDHVHQFSIITDLLGSPPKDVINTICSENTLK-FVTS 255

Human   301 RPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDP 365
            .|....:.|            ||..|.....|.|||.||||.||.|||:..|||.|||...::||
Yeast   256 LPHRDPIPF------------SERFKTVEPDAVDLLEKMLVFDPKKRITAADALAHPYSAPYHDP 308

Human   366 AEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPS 430
            .: |......:|...::.:..::.|:.::|.|:::..   |.|...||
Yeast   309 TD-EPVADAKFDWHFNDADLPVDTWRVMMYSEILDFH---KIGGSDGQ----------------- 352

Human   431 SSVNDISSMSTDQTLASDTDSSLEASA 457
               .|||:...|| :|:.|.::.:|.|
Yeast   353 ---IDISATFDDQ-VAAATAAAAQAQA 375

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MAPK10	NP_001304998.1	STKc_JNK	63..398	CDD:270840	139/338 (41%)
		S_TKc	64..359	CDD:214567	131/298 (44%)
HOG1	NP_013214.1	STKc_Sty1_Hog1	12..339	CDD:270843	140/347 (40%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	2	1.870