Protein Alignment MAPK10 and p38a

DIOPT Version :9

• Sequence 1: NP_001304998.1
• Gene: MAPK10 / 5602
• HGNCID: 6872
• Length: 478
• Species: Homo sapiens
• Sequence 2: NP_001163711.1
• Gene: p38a / 42866
• FlyBaseID: FBgn0015765
• Length: 366
• Species: Drosophila melanogaster
• Alignment Length: 389
• Identity: 178/389 - (45%)
• Similarity: 252/389 - (64%)
• Gaps: 34/389 - (8%)

Human    39 MSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQT 103
            ||.| :..:||.:::..:.:.:...||:|:|:||||.|.|..|.....:.:||||||:||||:..
  Fly     1 MSVS-ITKKFYKLDINRTEWEIPDIYQDLQPVGSGAYGQVSKAVVRGTNMHVAIKKLARPFQSAV 64

Human   104 HAKRAYRELVLMKCVNHKNIISLLNVFTPQK---TLEEFQDVYLVMELMDANLCQVIQME-LDHE 164
            ||||.||||.|:|.::|:|:|.||::|.|..   :||.||.||||..||||:|..:|:|: |..:
  Fly    65 HAKRTYRELRLLKHMDHENVIGLLDIFHPHPANGSLENFQQVYLVTHLMDADLNNIIRMQHLSDD 129

Human   165 RMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYY 229
            .:.:|:||:|.|:|::||||:||||||||||.|..||.|:||||||||.  |...||.||.||:|
  Fly   130 HVQFLVYQILRGLKYIHSAGVIHRDLKPSNIAVNEDCELRILDFGLARP--TENEMTGYVATRWY 192

Human   230 RAPEVILG-MGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKL-QP 292
            ||||::|. |.|.:.||||||||||.|::..:.||||.|:|.|.|.::|.||||..||:||: ..
  Fly   193 RAPEIMLNWMHYDQTVDIWSVGCIMAELITRRTLFPGTDHIHQLNLIMEMLGTPPAEFLKKISSE 257

Human   293 TVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHP 357
            :.|:|:::.|...|.:|..:|.::        |.|    |.|||.|||.:|..|||:.::||.||
  Fly   258 SARSYIQSLPPMKGRSFKNVFKNA--------NPL----AIDLLEKMLELDAEKRITAEEALSHP 310

Human   358 YINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAV 421
            |:..:.:|:..:..||  ||...::.:..:::|||||||||.|.           :|.||.|.|
  Fly   311 YLEKYAEPSVEQTSPP--YDHSFEDMDLPVDKWKELIYKEVTNF-----------KPPPSYAQV 361

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MAPK10	NP_001304998.1	STKc_JNK	63..398	CDD:270840	165/340 (49%)
		S_TKc	64..359	CDD:214567	152/300 (51%)
p38a	NP_001163711.1	STKc_p38	9..354	CDD:143356	170/371 (46%)
		S_TKc	25..312	CDD:214567	152/300 (51%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910