Protein Alignment MAPK10 and rl

DIOPT Version :9

• Sequence 1: NP_001304998.1
• Gene: MAPK10 / 5602
• HGNCID: 6872
• Length: 478
• Species: Homo sapiens
• Sequence 2: NP_001015122.1
• Gene: rl / 3354888
• FlyBaseID: FBgn0003256
• Length: 376
• Species: Drosophila melanogaster
• Alignment Length: 389
• Identity: 148/389 - (38%)
• Similarity: 238/389 - (61%)
• Gaps: 39/389 - (10%)

Human    35 KHYNMSKSKVDNQFYSVEVGDSTFTVLK--------RYQNLKPIGSGAQGIVCAAYDAVLDRNVA 91
            :.:|.|.|.| |...|.||..|...|::        ||..|..||.||.|:|.:|.|.:.::.||
  Fly     2 EEFNSSGSVV-NGTGSTEVPQSNAEVIRGQIFEVGPRYIKLAYIGEGAYGMVVSADDTLTNQRVA 65

Human    92 IKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQV 156
            |||:| ||::||:.:|..||:.::....|:|||.:.::.... ::::.:|||:|..||:.:|.::
  Fly    66 IKKIS-PFEHQTYCQRTLREITILTRFKHENIIDIRDILRVD-SIDQMRDVYIVQCLMETDLYKL 128

Human   157 IQME-LDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAG----- 215
            ::.: |.::.:.|.|||:|.|:|::|||.::||||||||:::...|.|||.||||||.|.
  Fly   129 LKTQRLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNKTCDLKICDFGLARIADPEHDH 193

Human   216 TSFMMTPYVVTRYYRAPEVIL-GMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQL 279
            |.| :|.||.||:|||||::| ..||.:::||||||||:.||:.::.:|||:.|:||.|.::..|
  Fly   194 TGF-LTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGVL 257

Human   280 GTPCPEFMK-KLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVID 343
            |:|..:.:: .:....|||:|:.|....:.:.||||:    ||        :.|.|||.|||..:
  Fly   258 GSPSRDDLECIINEKARNYLESLPFKPNVPWAKLFPN----AD--------ALALDLLGKMLTFN 310

Human   344 PAKRISVDDALQHPYINVWYDPAE---VEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEK 404
            |.|||.|::||.|||:..:|||.:   .|.|    :...::..:.:.:..|.||::|.:..:|:
  Fly   311 PHKRIPVEEALAHPYLEQYYDPGDEPVAEVP----FRINMENDDISRDALKSLIFEETLKFKER 370

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MAPK10	NP_001304998.1	STKc_JNK	63..398	CDD:270840	136/345 (39%)
		S_TKc	64..359	CDD:214567	126/302 (42%)
rl	NP_001015122.1	STKc_ERK1_2_like	32..366	CDD:270839	137/352 (39%)
		S_TKc	38..326	CDD:214567	126/302 (42%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D741207at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.920