Protein Alignment MAPK10 and p38c

DIOPT Version :10

• Sequence 1: NP_001304998.1
• Gene: MAPK10 / 5602
• HGNCID: 6872
• Length: 478
• Species: Homo sapiens
• Sequence 2: NP_996277.1
• Gene: p38c / 2768679
• FlyBaseID: FBgn0267339
• Length: 356
• Species: Drosophila melanogaster
• Alignment Length: 361
• Identity: 136/361 - (37%)
• Similarity: 206/361 - (57%)
• Gaps: 24/361 - (6%)

Human    47 QFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRE 111
            :|..|.:.:|.:.....|:.::.:|.|:.|.|........:...|:|:|.|||:.:..||..|||
  Fly     3 EFVRVAINESLWEFPDIYEFVRFLGGGSFGQVAKVRLRGTENYFAMKRLMRPFEREEDAKGTYRE 67

Human   112 LVLMKCVNHKNIISLLNVF-TPQKTLEEFQDVYLVMELMDANLCQVIQME-LDHERMSYLLYQML 174
            :.|:|.:||:|:||||||| .|...:.|||.||||..||||:|.:..:.: :..:.:..:|||:|
  Fly    68 IRLLKHMNHRNVISLLNVFHPPAHNMMEFQQVYLVTHLMDADLHRYSRSKRMSDQEIRIILYQIL 132

Human   175 CGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMG 239
            .|:|::||||::||||||.||.|..:..::||||||:|.....  ||.:|.|.:|.|||:|...|
  Fly   133 RGLKYIHSAGVVHRDLKPCNIAVNGNSEVRILDFGLSRMCADK--MTDHVGTMWYLAPEIIFLRG 195

Human   240 -YKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKL-QPTVRNYVENRP 302
             |.:.:|:||||||:.|::..::||.|.:|:.|...:|..:|||..||:..: ....|||:|..|
  Fly   196 QYTKAIDVWSVGCILAELITDRVLFRGENYVSQIRCLINIMGTPTREFITGISMERSRNYLEGYP 260

Human   303 KYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDP-- 365
            ......|..||..            ...||.||:.|||.:.|.|||:..:|:.|||:....:|
  Fly   261 LRQRCDFHHLFMG------------YDVQAIDLMEKMLEMVPEKRITAAEAMLHPYLRDLIEPHH 313

Human   366 -AEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMN 400
             ||..||   :||:..:.....::.||||:..|:.|
  Fly   314 HAEDTAP---VYDQNFENMVLPVKCWKELVSHEIRN 346

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MAPK10	NP_001304998.1	STKc_JNK	63..398	CDD:270840	131/341 (38%)
p38c	NP_996277.1	STKc_p38	4..349	CDD:143356	136/360 (38%)